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Furazolidone

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Identification
Molecular formula
C8H7N3O5
CAS number
67-45-8
IUPAC name
5-amino-N-methyl-3-(5-nitro-2-furyl)-1,2,4-triazole-1-carboxamide
State
State

At room temperature, Furazolidone is in a solid state as a yellow, crystalline powder.

Melting point (Celsius)
258.00
Melting point (Kelvin)
531.15
Boiling point (Celsius)
200.00
Boiling point (Kelvin)
473.15
General information
Molecular weight
225.16g/mol
Molar mass
225.1640g/mol
Density
1.5420g/cm3
Appearence

Furazolidone is typically a yellow, crystalline powder.

Comment on solubility

Solubility of 5-amino-N-methyl-3-(5-nitro-2-furyl)-1,2,4-triazole-1-carboxamide (C8H7N3O5)

The solubility characteristics of 5-amino-N-methyl-3-(5-nitro-2-furyl)-1,2,4-triazole-1-carboxamide are of significant interest due to its complex structure. Solubility can be influenced by several factors, making it essential to consider the following:

  • Polarity: The presence of functional groups such as the carboxamide and nitro groups contributes to the compound's polarity, promoting solubility in polar solvents.
  • Hydrogen Bonding: The potential for hydrogen bonding, especially with water molecules, plays a crucial role in its solubility. The carboxamide group is particularly effective in enhancing solubility in polar media.
  • Environmental Factors: Factors such as temperature can significantly impact solubility behavior. As temperature increases, the solubility of many organic compounds typically increases.

This compound is likely to exhibit stable solubility in solvents like dimethyl sulfoxide (DMSO) or dimethylformamide (DMF), while its effectiveness in water may vary. Experimental solubility data often highlights that:

  1. In aqueous solutions, the solubility can be limited due to the hydrophobic characteristics of certain structural components.
  2. In organic solvents, it tends to have significantly improved solubility, making it easier to incorporate into various applications.

Understanding the solubility of this compound is crucial for practical applications, especially in pharmaceutical formulations and agrochemical preparations. The balance of its structural factors ultimately dictates its behavior in different chemical environments.

Interesting facts

Interesting Facts about 5-amino-N-methyl-3-(5-nitro-2-furyl)-1,2,4-triazole-1-carboxamide

This fascinating compound belongs to the class of triazole derivatives, known for their diverse applications in medicinal chemistry and agriculture. Here are some intriguing points to note:

  • Pharmaceutical Potential: The triazole ring structure is a common feature in many pharmaceutical agents, particularly antifungal and antimicrobial compounds. Its unique chemical properties allow for interactions that can disrupt fungal cell wall synthesis.
  • Furyl Substitution: The presence of a nitro furyl group enhances the compound's biological activities and is known to contribute to the effectiveness of several agrochemicals.
  • Amino Group Role: The amino group at the 5-position plays a crucial role in imparting solubility and enhancing the compound’s reactivity, which can be strategically exploited in various synthetic pathways.
  • Potential Anti-Cancer Activity: Preliminary studies suggest that compounds similar to this one could exhibit significant anti-cancer properties, further highlighting the need for ongoing research into their biological mechanisms.

In research environments, compounds such as 5-amino-N-methyl-3-(5-nitro-2-furyl)-1,2,4-triazole-1-carboxamide are often synthesized to explore their structure-activity relationships. As chemists continue to modify this compound, the resulting derivatives may unveil even greater therapeutic potential.

Overall, with its combination of functional groups and ring systems, this compound exemplifies the innovative spirit of modern chemistry, bridging the gap between fundamental science and practical application.

Synonyms
5-amino-N-methyl-3-(5-nitrofuran-2-yl)-1,2,4-triazole-1-carboxamide
10227-66-4
DTXSID40274783