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5-Benzamido-N-(4-ethoxyphenyl)-3-methylisothiazole-4-carboxamide

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Identification
Molecular formula
C19H19N3O3S
CAS number
3390-22-9
IUPAC name
5-benzamido-N-(4-ethoxyphenyl)-3-methyl-isothiazole-4-carboxamide
State
State

At room temperature, 5-Benzamido-N-(4-ethoxyphenyl)-3-methylisothiazole-4-carboxamide is typically a solid. It is generally handled as a powder and should be kept in a dry environment to prevent any potential degradation or unwanted reactions.

Melting point (Celsius)
221.00
Melting point (Kelvin)
494.15
Boiling point (Celsius)
375.50
Boiling point (Kelvin)
648.65
General information
Molecular weight
384.45g/mol
Molar mass
384.4520g/mol
Density
1.3314g/cm3
Appearence

The compound appears as a white or off-white powder. The texture is typically crystalline, and it may exhibit a slight odor characteristic of organic isothiazole compounds.

Comment on solubility

Solubility of 5-benzamido-N-(4-ethoxyphenyl)-3-methyl-isothiazole-4-carboxamide

The solubility of 5-benzamido-N-(4-ethoxyphenyl)-3-methyl-isothiazole-4-carboxamide can be influenced by various factors, including its molecular structure and the presence of functional groups. Generally, the solubility characteristics for this compound can be summarized as follows:

  • Polarity: The presence of an amide functional group is likely to enhance solubility in polar solvents due to hydrogen bonding.
  • Hydrophobic regions: The ethoxy and benzamido substituents contribute hydrophobic characteristics, suggesting that non-polar solvents may also dissolve this compound to a certain extent.
  • pH Dependence: The solubility can vary with changes in pH, particularly due to potential ionization of the carboxamide group.
  • Temperature Effects: Like many organic compounds, increased temperature may enhance solubility in a given solvent.

In practice, this compound is likely to show moderate solubility in a variety of organic solvents, with recommendations for testing specific solvents like methanol, ethanol, and dimethyl sulfoxide. It's essential to consider that experimental determination remains the best approach to definitively assess its solubility characteristics.

Interesting facts

5-benzamido-N-(4-ethoxyphenyl)-3-methyl-isothiazole-4-carboxamide

This intriguing chemical compound, known for its diverse applications, belongs to the class of isothiazoles, which are distinct for their incorporation of sulfur and nitrogen in a six-membered ring. Here are some fascinating aspects of this compound:

  • Unique Structure: The compound features a complex structure that combines multiple functional groups. This includes an isothiazole ring, which is often associated with various biological activities, making it a subject of significant research.
  • Biological Relevance: Many isothiazole derivatives have shown promise in pharmaceutical research, particularly in fields such as anti-cancer and anti-inflammatory drug development. This particular compound may exhibit similar properties, contributing to its appeal in medicinal chemistry.
  • Potential Applications: The presence of the benzamide moiety suggests potential applications in the realm of agrochemicals and pharmaceuticals. Compounds like this one could serve as herbicides or fungicides, owing to their ability to target specific biological pathways.
  • Synthetic Challenges: The synthesis of such complex molecules often presents challenges, including strategic planning of functional group modifications and preserving the integrity of the core structure during reactions.
  • Innovation in Research: Current studies continue to explore the properties and reactions of isothiazole derivatives. The ongoing research is geared towards understanding their mechanisms at the molecular level and establishing new uses in various fields.

This compound exemplifies the fusion of chemistry and biology, serving as a rich subject of study for both students and seasoned chemists alike. Understanding its properties may lead to significant advancements in several scientific domains.

Synonyms
BRN 1164396
4-ISOTHIAZOLECARBOXY-p-PHENETIDIDE, 5-BENZAMIDO-3-METHYL-
5-Benzamido-3-methyl-4-isothiazolecarboxy-p-phenetidide
25392-07-8
3-Methyl-5-benzoylaminoisothiazole-4-carboxy-p-ethoxyphenylamide
DTXSID50180043
RefChem:293675
DTXCID60102534