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Keto-profen

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Identification
Molecular formula
C16H14NO3
CAS number
22071-15-4
IUPAC name
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
State
State

At room temperature, keto-profen is a solid substance. It remains stable under ordinary conditions and can be ground into a fine powder for medicinal purposes.

Melting point (Celsius)
94.50
Melting point (Kelvin)
367.65
Boiling point (Celsius)
386.70
Boiling point (Kelvin)
659.85
General information
Molecular weight
254.28g/mol
Molar mass
254.2830g/mol
Density
1.1850g/cm3
Appearence

Keto-profen is a white, crystalline powder. It is typically odorless and has a bitter taste. The compound can sometimes form in large crystals under certain conditions.

Comment on solubility

Solubility of 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

The solubility of 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid (C16H14NO3) can be influenced by various factors, including its molecular structure and environmental conditions. Here are some key points regarding its solubility:

  • Polarity: The presence of the carboxylic acid functional group (-COOH) suggests that this compound may exhibit some level of polarity, which could enhance its solubility in polar solvents such as water.
  • Steric Hindrance: The bulky benzoyl group may create steric hindrance that could potentially affect the compound’s interaction with solvent molecules, possibly limiting solubility in non-polar solvents.
  • Solvent Dependency: Solubility may vary significantly based on the choice of solvent. For example, polar aprotic solvents like dimethyl sulfoxide (DMSO) might accommodate better solubility compared to non-polar solvents.

In conclusion, "the solubility of 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid is expected to be low in non-polar environments, yet it may display more favorable solubility characteristics in polar solvents," reflecting the delicate balance in organic compounds driven by their structural attributes and the surrounding chemical environment.

Interesting facts

Interesting Facts about 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

This intriguing compound is a member of the pyrrolizine family, which are noteworthy for their diverse applications in organic chemistry and medicinal chemistry. Here are some fascinating aspects of this compound:

  • Structural Diversity: The structural configuration of 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid is characterized by the presence of both a pyrrolizine ring and a benzoyl moiety, incorporating multiple functional groups that can participate in various chemical reactions.
  • Pharmacological Potential: Compounds similar to 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid are often explored for their biological activity, leading to potential applications in drug discovery, especially in the realm of anti-inflammatory and anti-cancer agents.
  • Research Relevance: This compound has been studied in the context of synthetic organic chemistry, providing valuable insights into the reactivity patterns of pyrrolizine derivatives and their ability to serve as intermediates in complex organic syntheses.
  • Synthetic Pathways: The synthesis of such compounds often involves innovative methods, including cycloaddition reactions and functionalization techniques that challenge chemists to develop more efficient synthetic routes.
  • Environmental Considerations: As with many chemical substances, understanding the behavior of 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid in the environment and its potential effects on ecological systems is important for its safe use and application.

In conclusion, 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid serves as a compelling example of how intricate molecular structures can lead to broad scientific exploration and innovation. Each layer of complexity in its design opens avenues for future research and applications in various fields!

Synonyms
ketorolac
74103-06-3
5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
Ketorolaco
Ketorolacum
(+-)-Ketorolac
Ketorolacum [Latin]
Ketorolaco [Spanish]
66635-83-4
Ketoralac
Macril
rac-ketorolac
RS 37619
rac Ketorolac
UNII-YZI5105V0L
Ketorolac (INN)
YZI5105V0L
(+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
Toradol (TN)
MFCD00864281
CHEBI:6129
DTXSID8023189
CHEBI:76223
Ketorolacum (Latin)
RS37619
KETOROLAC [INN]
(1RS)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
1H-Pyrrolizine-1-carboxylic acid, 2,3-dihydro-5-benzoyl-, (+-)-
5-(phenylcarbonyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
Ketorolac [INN:BAN]
RS-37619
rac-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
NCGC00185990-01
Toraldar
1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-
Ketorolac (NSAID)
Ketorolac (Standard)
1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro
KETOROLAC [MI]
KETOROLAC [VANDF]
CHEMBL469
KETOROLAC [WHO-DD]
SCHEMBL14891
MLS006011844
DTXCID503189
GTPL6661
BDBM85511
HY-B0580R
M01AB15
S01BC05
HMS3604J05
HMS3884M04
HY-B0580
QYB76766
RYB45153
AC-545
s1646
STL018674
AKOS005657203
AC-1121
CCG-204762
DB00465
FK35139
IB58062
KS-5175
SDCCGSBI-0050655.P004
NCGC00185990-02
NCGC00185990-05
NCGC00185990-15
SMR001550090
SY107530
SBI-0050655.P003
CAS_74103-07-4
DB-011403
AB00053682
NS00009482
C07062
D08104
EN300-170843
F16555
AB00053682-12
AB00053682-14
AB00053682_15
AB00053682_16
Q2014797
BRD-A40639672-001-01-9
BRD-A40639672-234-05-7
BRD-A40639672-234-09-9
BRD-A40639672-234-17-2
BRD-A40639672-234-18-0
5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylicacid
KETOROLAC, ketorolactromethamine, Ketorolac Tromethamine
Z2429420872
5-(benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid #
(+/-)-5-benzoyl-2,3-dihydro-1h-pyrrolizine-1-carboxylic acid
(.+/-.)-2,3-Dihydro-5-benzoyl-1H-pyrrolizine-1-carboxylic acid
(.+/-.)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid
5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid - Racemic
1H-Pyrrolizine-1-carboxylic acid, 2,3-dihydro-5-benzoyl-, (.+/-.)-
1H-PYRROLIZINE-1-CARBOXYLIC ACID, 5-BENZOYL-2,3-DIHYDRO, (+/-)-
5-BENZOYL-2,3-DIHYDRO-1H-PYRROLO[1,2-A]PYRROLE-1-CARBOXYLIC ACID