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5-bromo-3-(1-methylpyrrolidin-2-yl)-1H-indole

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Identification
Molecular formula
C13H15BrN2
CAS number
1169-65-5
IUPAC name
5-bromo-3-(1-methylpyrrolidin-2-yl)-1H-indole
State
State

At room temperature, 5-bromo-3-(1-methylpyrrolidin-2-yl)-1H-indole exists as a solid. It has a relatively high melting point, which is indicative of its solid form under standard conditions.

Melting point (Celsius)
117.20
Melting point (Kelvin)
390.35
Boiling point (Celsius)
392.50
Boiling point (Kelvin)
665.65
General information
Molecular weight
287.18g/mol
Molar mass
287.1410g/mol
Density
1.5675g/cm3
Appearence

The compound appears as a solid, typically with a crystalline structure. It has a pale yellow to off-white color, which is typical for many organic brominated compounds.

Comment on solubility

Solubility of 5-bromo-3-(1-methylpyrrolidin-2-yl)-1H-indole

The solubility of 5-bromo-3-(1-methylpyrrolidin-2-yl)-1H-indole can be quite intriguing due to its structural characteristics. Here are some key points to consider:

  • Polarity: The compound contains both bromine and a pyrrolidine moiety, which can influence its solubility in different solvents.
  • Solvent Interaction: It is expected to exhibit better solubility in polar solvents such as methanol and ethanol compared to non-polar solvents due to the presence of polar functional groups.
  • Hydrogen Bonding: The ability to form hydrogen bonds with solvents can enhance solubility. The nitrogen in the pyrrolidine ring could facilitate such interactions.
  • Temperature Effect: Like many organic compounds, increased temperature may improve solubility in certain solvents.

In summary, while exact solubility data may not be readily available, based on its structure, 5-bromo-3-(1-methylpyrrolidin-2-yl)-1H-indole is likely to be more soluble in polar solvents and its solubility may be influenced by functional group interactions, temperature, and solvent type.

Interesting facts

Interesting Facts about 5-Bromo-3-(1-methylpyrrolidin-2-yl)-1H-indole

The compound 5-bromo-3-(1-methylpyrrolidin-2-yl)-1H-indole is a fascinating molecule that falls within the realm of indole derivatives, which are known for their significant biological and pharmacological activities. Indole itself, as a foundational structure, is prominent in various natural products and pharmaceutical agents.

Here are some intriguing aspects of this compound:

  • Biological Significance: Indole derivatives have been linked to a variety of biological functions, including their roles as neurotransmitters or their involvement in preventing tumor growth.
  • Pharmacological Applications: Research suggests that compounds structurally related to indole may possess potential therapeutic properties, including anti-inflammatory, analgesic, and neuroprotective effects.
  • Aromaticity: The indole structure contributes to the stability and reactivity of the compound due to its unique aromatic system, allowing for fascinating reactivity patterns in synthetic chemistry.
  • Substituent Effects: The presence of the bromine atom and the pyrrolidine moiety affect both the chemical properties and the biological activity of this indole derivative, making it a subject of interest in drug design.
  • Research Interest: New derivatives are continually being studied for their potential uses in the development of new medications, owing to the indole's versatility in modifying pharmacological profiles.

Notably, as the field of medicinal chemistry progresses, compounds like 5-bromo-3-(1-methylpyrrolidin-2-yl)-1H-indole serve as crucial building blocks for exploring innovative treatments for complex diseases, with researchers eager to unlock further secrets of this structure. As one researcher put it, “Every indole derivative tells a different story, often leading us to unexpected discoveries.”

Ultimately, the study of such compounds not only enhances our understanding of organic chemistry but also paves the way for groundbreaking advancements in medicine.

Synonyms
5-Bromo-3-(1-methyl-2-pyrrolidinyl)indole
19137-86-1
BRN 0524761
INDOLE, 5-BROMO-3-(1-METHYL-2-PYRROLIDINYL)-
5-bromo-3-(1-methylpyrrolidin-2-yl)-1H-indole
SCHEMBL13587929
DTXSID30940748