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5-Bromo-4-nitroimidazole

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Identification
Molecular formula
C3H2BrN3O2
CAS number
6986-64-1
IUPAC name
5-bromo-4-nitro-1H-imidazole
State
State

At room temperature, 5-Bromo-4-nitro-1H-imidazole is typically found in a solid state, often as crystalline powder or crystals.

Melting point (Celsius)
263.00
Melting point (Kelvin)
536.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
208.97g/mol
Molar mass
208.9690g/mol
Density
0.0000g/cm3
Appearence

5-Bromo-4-nitro-1H-imidazole typically appears as a crystalline solid. The color can vary but it often appears as off-white to brownish crystals or powder. Its appearance holds for its pure form without any impurities which might alter its hue.

Comment on solubility

Solubility of 5-bromo-4-nitro-1H-imidazole

The solubility of 5-bromo-4-nitro-1H-imidazole is an intriguing aspect that showcases its interaction with solvents. This compound is known to exhibit varying degrees of solubility depending on the solvent used. Here are some key points to consider:

  • Water Solubility: Generally, 5-bromo-4-nitro-1H-imidazole has limited solubility in water. This characteristic can be attributed to its relatively hydrophobic structure, which discourages strong interactions with polar water molecules.
  • Organic Solvents: In contrast, this compound demonstrates enhanced solubility in organic solvents such as dimethyl sulfoxide (DMSO), ethanol, and acetone. The presence of the bromine and nitro groups contributes to increased solubility in these non-polar or slightly polar environments.
  • Temperature Effect: Solubility can also vary with temperature, often increasing as the temperature rises in organic solvents.
  • pH Dependence: The solubility may be affected by the pH of the solvent, especially in solutions that can ionize functional groups present in the compound.

Understanding the solubility properties of 5-bromo-4-nitro-1H-imidazole is essential for its practical applications in organic synthesis and pharmaceuticals. As the adage goes, “Like dissolves like,” and this principle should be kept in mind when considering the solubility behavior of this compound.


Interesting facts

Interesting Facts about 5-Bromo-4-nitro-1H-imidazole

5-Bromo-4-nitro-1H-imidazole is a fascinating compound that belongs to the imidazole class of compounds which plays a significant role in various biological and chemical processes. Here are some noteworthy points about this intriguing molecule:

  • Pharmacological Relevance: This compound is of interest in medicinal chemistry due to its potential use in pharmaceuticals. Derivatives of imidazole are known to exhibit antimicrobial, antifungal, and anti-inflammatory activities.
  • Substituent Influence: The presence of bromine and nitro groups in its structure allows for interesting chemical reactivity and opens up pathways for further derivatization. Substituents can dramatically affect the physical and biological properties of compounds.
  • Role in Biochemistry: Imidazole derivatives, including 5-bromo-4-nitro-1H-imidazole, are key components in the structure of histidine, an essential amino acid. Histidine plays critical roles in enzyme catalysis and metal ion chelation.
  • Analytical Applications: This compound can be used in various analytical techniques and methodologies in the laboratory, including high-performance liquid chromatography (HPLC) and UV-Vis spectroscopy, to analyze and determine concentrations of related compounds.
  • Research Opportunities: The unique structure of 5-bromo-4-nitro-1H-imidazole presents many opportunities for research in developing selective inhibitors and new therapeutic agents targeting specific biological pathways.

Overall, 5-bromo-4-nitro-1H-imidazole is much more than just a chemical compound; it serves as an example of how intricate structures can lead to diverse applications in science and medicine. As research continues to advance in this field, the understanding of such compounds will undoubtedly lead to a plethora of innovative solutions and discoveries.