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5-Bromo-4-nitro-2-(trifluoromethyl)-1H-benzimidazole

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Identification
Molecular formula
C8H3BrF3N3O2
CAS number
35170-07-9
IUPAC name
5-bromo-4-nitro-2-(trifluoromethyl)-1H-benzimidazole
State
State

At room temperature, 5-Bromo-4-nitro-2-(trifluoromethyl)-1H-benzimidazole is usually in a solid-state. Its crystalline form makes it stable and manageable for synthetic chemistry applications. The compound's solid state contributes to its longevity in storage conditions typical of laboratory environments.

Melting point (Celsius)
166.00
Melting point (Kelvin)
439.00
Boiling point (Celsius)
308.00
Boiling point (Kelvin)
581.00
General information
Molecular weight
310.99g/mol
Molar mass
310.9920g/mol
Density
1.8900g/cm3
Appearence

5-Bromo-4-nitro-2-(trifluoromethyl)-1H-benzimidazole appears as a yellow crystalline solid. The compound is noted for its pale yellow coloration, which is characteristic of many nitro-containing aromatic compounds. Its crystalline nature makes it easy to handle in the laboratory environment for various chemical procedures.

Comment on solubility

Solubility of 5-Bromo-4-nitro-2-(trifluoromethyl)-1H-benzimidazole

The solubility of 5-bromo-4-nitro-2-(trifluoromethyl)-1H-benzimidazole in various solvents can be an intriguing aspect of its chemical behavior. Here are some key points to consider:

  • Polarity: This compound contains both polar and nonpolar functional groups, which influences its solubility in polar vs nonpolar solvents.
  • Solvent Comparison:
    • It is likely to exhibit higher solubility in organic solvents such as DMSO (dimethyl sulfoxide) and DMF (dimethylformamide).
    • In contrast, its solubility in water may be limited due to the presence of the bulky trifluoromethyl and bromo groups.
  • Temperature Dependence: The solubility generally increases with temperature. Higher temperatures can help dissolve more of the compound in a given solvent.
  • pH Stability: pH can affect the solubility of this compound as well. In acidic or basic conditions, the interaction with solvent molecules can vary significantly.

Overall, while 5-bromo-4-nitro-2-(trifluoromethyl)-1H-benzimidazole may not be highly soluble in aqueous solutions, it shows better solubility characteristics in suitable organic solvents. As always, consulting specific solubility data under standard conditions is advisable for precise applications.

Interesting facts

Interesting Facts about 5-Bromo-4-Nitro-2-(Trifluoromethyl)-1H-Benzimidazole

5-Bromo-4-nitro-2-(trifluoromethyl)-1H-benzimidazole is a fascinating compound in the field of medicinal chemistry, often making headlines due to its potential applications. Here are some noteworthy aspects:

  • Pharmacological Potential: This compound has shown promise in various pharmacological studies, particularly as a candidate for developing new drugs targeted towards antimicrobial and anti-cancer therapies.
  • Fluorine Chemistry: The presence of the trifluoromethyl group is particularly intriguing. Compounds with fluorine atoms are known to exhibit enhanced metabolic stability and lipophilicity, making them more effective in biological systems.
  • Cross-Disciplinary Interest: Researchers from fields such as organic synthesis, medicinal chemistry, and materials science find applications for this compound, highlighting its versatility and importance across various domains.
  • Explosive Reactivity: The nitro group within the structure can lead to explosive reactivity under certain conditions, thus emphasizing the need for careful handling and storage of this compound in a laboratory setting.
  • Comparison to Other Compounds: Benzimidazoles are a well-established class of compounds with a broad range of biological activities. The modifications at the 5, 4, and 2 positions enhance the unique properties of this particular benzimidazole, making it a subject of extensive research.

In conclusion, 5-bromo-4-nitro-2-(trifluoromethyl)-1H-benzimidazole is a compound rich with possibilities. Its properties and reactivity not only provide insight into chemical behavior but also pave the way for future innovations in drug discovery!

Synonyms
14689-58-8
BENZIMIDAZOLE, 5-BROMO-4-NITRO-2-(TRIFLUOROMETHYL)-
BRN 0927132
5-Bromo-4-nitro-2-(trifluoromethyl)benzimidazole
DTXSID70163535
DTXCID8086026
5-bromo-4-nitro-2-(trifluoromethyl)-1H-benzimidazole
5-BROMO-4-NITRO-2-(TRIFLUOROMETHYL)-1H-1,3-BENZODIAZOLE
6-Bromo-7-nitro-2-(trifluoromethyl)-1H-benzo[d]imidazole
YFYACJUPYYEJMJ-UHFFFAOYSA-N
EN300-22848278