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Clonazepam

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Identification
Molecular formula
C15H10ClN3O3
CAS number
1622-61-3
IUPAC name
5-chloro-1-[3-(dimethylamino)propyl]-3-phenyl-benzimidazol-2-one
State
State

At room temperature, clonazepam is a solid.

Melting point (Celsius)
239.00
Melting point (Kelvin)
512.00
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.00
General information
Molecular weight
315.71g/mol
Molar mass
315.7140g/mol
Density
1.4000g/cm3
Appearence

Clonazepam typically occurs as a white to light yellow crystalline powder. It is odorless and has a bitter taste.

Comment on solubility

Solubility of 5-chloro-1-[3-(dimethylamino)propyl]-3-phenyl-benzimidazol-2-one

The solubility of 5-chloro-1-[3-(dimethylamino)propyl]-3-phenyl-benzimidazol-2-one can be influenced by a variety of factors, including its molecular structure and the presence of functional groups. Understanding its solubility is crucial for determining its applications in various fields.

Key Factors Affecting Solubility:

  • Molecular Interactions: The presence of the dimethylamino group is likely to enhance solubility in polar solvents due to hydrogen bonding.
  • Hydrophobic Regions: The phenyl and benzimidazole rings contribute to hydrophobic interactions, which may limit solubility in aqueous solutions.
  • pH Sensitivity: The compound may exhibit variable solubility across different pH levels, affecting its ionization and consequently its solubility profile.

In general, compounds with polar substituents tend to be more soluble in polar solvents, while nonpolar regions promote solubility in organic solvents. Therefore, the solubility of this compound may be described as:

  • Soluble: In organic solvents like DMSO or ethanol
  • Partially Soluble: In water, depending on specific conditions such as temperature and pH

As a rule of thumb, “like dissolves like” holds true, meaning that finding the right solvent can make all the difference in solubility. Further experimental investigation would be beneficial to elucidate the exact solubility characteristics of this intriguing compound.

Interesting facts

Interesting Facts about 5-Chloro-1-[3-(dimethylamino)propyl]-3-phenyl-benzimidazol-2-one

5-Chloro-1-[3-(dimethylamino)propyl]-3-phenyl-benzimidazol-2-one is a fascinating compound with numerous applications in both medicinal and research fields. Here are some intriguing aspects:

  • Pharmaceutical Potential: This compound is part of the benzimidazole class, which has shown a variety of biological activities, including anti-inflammatory and anti-cancer properties. Compounds similar to this structure have been studied for their potential in treating conditions like cancer and bacterial infections.
  • Structure and Function: The presence of the dimethylamino group enhances the lipophilicity of the molecule, making it more permeable through biological membranes. This characteristic is crucial for drug design, as it can improve bioavailability.
  • Clarity of Design: The inclusion of the chloro substituent and the phenyl group adds to the compound's diversity, allowing for the modulation of its chemical properties, which can influence its efficacy and selectivity in biological systems.
  • Research Interest: Ongoing studies into related compounds often cite benzimidazole derivatives as promising leads for new pharmaceuticals, indicating a vibrant area of research that combines medicinal chemistry and organic synthesis.

This compound serves not only as an interesting point of study due to its diverse applications but also highlights the importance of structure-activity relationships in drug development. With continued exploration, it may pave the way for innovative therapies in modern medicine.

Synonyms
CLODAZON
Clodazone
4755-59-3
Clodazon [INN]
Clodazona
Clodazonum
Clodazone [INN-French]
Clodazonum [INN-Latin]
Clodazona [INN-Spanish]
UNII-X82H6JOC4H
X82H6JOC4H
BRN 0894387
5-Chloro-1-(3-(dimethylamino)propyl)-3-phenyl-2-benzimidazolinone
DTXSID30197194
AW-142446 FREE BASE
5-24-02-00399 (Beilstein Handbook Reference)
Clodazone (INN-French)
Clodazonum (INN-Latin)
Clodazona (INN-Spanish)
2-Benzimidazolinone, 5-chloro-1-(3-(dimethylamino)propyl)-3-phenyl-
2H-Benzimidazol-2-one, 5-chloro-1-(3-(dimethylamino)propyl)-1,3-dihydro-3-phenyl-
2H-BENZIMIDAZOL-2-ONE,5-CHLORO-1-(3-(DIMETHYLAMINO)PROPYL)-1,3-DIHYDRO-3-PHENYL-
DTXCID40119685
2H-Benzimidazol-2-one, 5-chloro-1-(3-(dimethylamino)propyl)-1,3-dihydro-3-phenyl-(9CI)
5-chloro-1-[3-(dimethylamino)propyl]-3-phenylbenzimidazol-2-one
SCHEMBL1156052
CHEMBL2110801
NS00126170
Q27293664