Skip to main content

5-Chloro-1-methyl-4-nitroimidazole

ADVERTISEMENT
Identification
Molecular formula
C4H4ClN3O2
CAS number
13321-51-6
IUPAC name
5-chloro-1-methyl-4-nitro-imidazole
State
State

At room temperature, 5-Chloro-1-methyl-4-nitroimidazole is in a solid state. This yellow crystalline compound typically remains stable in solid form under normal conditions.

Melting point (Celsius)
159.00
Melting point (Kelvin)
432.15
Boiling point (Celsius)
247.00
Boiling point (Kelvin)
520.15
General information
Molecular weight
162.54g/mol
Molar mass
162.5300g/mol
Density
1.4700g/cm3
Appearence

5-Chloro-1-methyl-4-nitroimidazole typically appears as a yellow crystalline solid. It may also be described as having a pale to warm yellow hue in its solid state.

Comment on solubility

Solubility of 5-chloro-1-methyl-4-nitro-imidazole

5-chloro-1-methyl-4-nitro-imidazole, a member of the imidazole family, presents a complex solubility profile due to its unique chemical structure. The solubility characteristics of this compound can be summarized as follows:

  • Polarity: The presence of the chloro and nitro functional groups contributes to its overall polarity, which can affect solubility in various solvents.
  • Aqueous Solubility: This compound is generally considered to have limited solubility in water, often attributed to its hydrophobic methyl group and the electron-withdrawing nature of the nitro group.
  • Organic Solvents: It tends to be more soluble in organic solvents such as dimethyl sulfoxide (DMSO), ethanol, and acetonitrile where its nonpolar characteristics can better interact with the solvent molecules.

As a general rule, compounds like 5-chloro-1-methyl-4-nitro-imidazole with functional groups that introduce both polarity and steric isolation can lead to:

  • Increased solubility in polar organic solvents.
  • Decreased solubility in nonpolar solvents.

In conclusion, the solubility of 5-chloro-1-methyl-4-nitro-imidazole is a fascinating interplay of its chemical properties, demonstrating how structural components influence interactions with different solvents. Understanding these solubility dynamics is crucial for applications in pharmaceuticals and material science.

Interesting facts

5-Chloro-1-methyl-4-nitro-imidazole: A Compound of Interest

5-Chloro-1-methyl-4-nitro-imidazole is an intriguing compound that falls within the realm of heterocyclic chemistry. This compound is particularly significant for a variety of applications and showcases several key features:

  • Biological Activity: This imidazole derivative exhibits pharmacological properties, making it valuable in medicinal chemistry. It has been studied for its potential roles as an antibiotic and antifungal agent.
  • Structural Versatility: The presence of multiple functional groups, such as the nitro and chloro substitutions, contributes to the compound's reactivity and allows for diverse synthetic pathways.
  • Industrial Importance: Due to its unique structure, 5-chloro-1-methyl-4-nitro-imidazole serves as an essential intermediate in the synthesis of various agrochemicals and pharmaceuticals.
  • Research Applications: Scientists continue to explore this compound in the context of drug design, utilizing its structure to optimize interactions with biological targets.

As highlighted in recent research, “the unique electronic properties provided by the nitro group can enhance the overall biological efficacy” of compounds like 5-chloro-1-methyl-4-nitro-imidazole. This demonstrates the profound impact that even minor structural changes can have on the properties of a compound.

This compound not only serves as a fascinating subject for study in advanced organic chemistry but also emphasizes the importance of heterocycles in pharmaceutical development and industrial applications. Its multidimensionality is what makes it a staple in contemporary chemical research.

Synonyms
5-CHLORO-1-METHYL-4-NITROIMIDAZOLE
4897-25-0
5-Chloro-1-methyl-4-nitro-1H-imidazole
1H-Imidazole, 5-chloro-1-methyl-4-nitro-
PCMNI
1-Methyl-5-chloro-4-nitroimidazole
Imidazole, 5-chloro-1-methyl-4-nitro-
1-methyl-4-nitro-5-chloroimidazole
EINECS 225-521-2
BRN 0136775
P917JW98BD
AI3-51948
S 50154-9
NSC 7852
NSC-7852
DTXSID00197646
AZATHIOPRINE IMPURITY C [EP IMPURITY]
AZATHIOPRINE IMPURITY C (EP IMPURITY)
DTXCID60120137
1-methyl-4-nitro-5-chloroimidazoles
225-521-2
MFCD00233664
CMNI
UNII-P917JW98BD
Azathioprine Imp. C (EP); 5-Chloro-1-methyl-4-nitroimidazole; Azathioprine Impurity C
1-methyl-4-nitro-5-chloro imidazole
MLS001049362
SCHEMBL3236045
CHEMBL1610328
NSC7852
HMS2797B15
ALBB-010478
BBL012664
STK744422
AKOS001116763
DS-0882
FC19985
HY-W094047
NCGC00246386-01
AC-11011
PD014739
SMR000427350
SY020982
5-Chloro-1-methyl-4-nitroimidazole, 98%
5-Chloro-1-methyl-4-nitro-1H-imidazole #
C1646
CS-0144974
NS00022228
A(S50154-9)
EN300-13362
Q27286392
Z57063140
5-Chloro-1-methyl-4-nitro-1H-imidazole;1-Methyl-4-nitro-5-chloroimidazole;NSC 7852