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5-chloro-1,3-benzothiazol-2-amine

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Identification
Molecular formula
C7H5ClN2S
CAS number
21443-45-8
IUPAC name
5-chloro-1,3-benzothiazol-2-amine
State
State

5-Chloro-1,3-benzothiazol-2-amine is typically in a solid state at room temperature.

Melting point (Celsius)
151.00
Melting point (Kelvin)
424.15
Boiling point (Celsius)
345.00
Boiling point (Kelvin)
618.15
General information
Molecular weight
184.64g/mol
Molar mass
184.6370g/mol
Density
1.5000g/cm3
Appearence

5-Chloro-1,3-benzothiazol-2-amine typically appears as a white to light yellow solid. It can have a powdery or crystalline texture depending on the specific sample and conditions of storage.

Comment on solubility

Solubility of 5-chloro-1,3-benzothiazol-2-amine

The solubility of 5-chloro-1,3-benzothiazol-2-amine can be a critical factor for its applications in various chemical processes. Understanding its solubility can often be summarized through the following key points:

  • Solvent Compatibility: This compound is generally more soluble in polar organic solvents, which facilitate interaction between the solute and solvent molecules.
  • Influence of Temperature: The solubility of such compounds often increases with temperature, promoting the dissolution process.
  • pH Sensitivity: The solubility may also be affected by the pH of the solution, as functional groups in the compound can gain or lose protons, altering their polarity.

In a broader context, the statement that “like dissolves like” can often be applied, suggesting that the choice of solvent should consider the polar nature of 5-chloro-1,3-benzothiazol-2-amine.
To summarize:

  1. Optimal solubility is attained in polar organic solvents.
  2. Increased temperature generally enhances solubility.
  3. The solubility can change with variations in pH.

Ultimately, understanding and manipulating these aspects of solubility will enhance its usability in synthesis and analysis, making it an important area of study within various fields of chemistry.

Interesting facts

Interesting Facts about 5-Chloro-1,3-benzothiazol-2-amine

5-Chloro-1,3-benzothiazol-2-amine is a fascinating compound with unique properties that make it significant in both scientific research and industrial applications. Here are some intriguing aspects of this chemical:

1. Chemical Structure and Functionality

  • This compound features a benzothiazole ring, which is a bicyclic structure containing both a thiazole and a benzene ring. This unique configuration can impart specific biological activities, making it useful in medicinal chemistry.
  • The presence of a chlorine atom at the 5-position contributes to its reactivity, allowing for potential modifications that can enhance its properties or effectiveness.

2. Applications in Research

  • 5-Chloro-1,3-benzothiazol-2-amine has been the subject of studies related to antifungal and antimicrobial properties, with the benzothiazole core often displaying significant biological activity.
  • Researchers are exploring its potential in the development of novel pharmacological agents, particularly in combatting resistant strains of bacteria or fungi.

3. Synthetic Pathways

The synthesis of this compound can often involve:

  • Substitutions on the benzothiazole core, allowing for a diverse range of derivatives that may enhance potency or specificity.
  • Utilization of base-catalyzed or acid-catalyzed reactions to achieve desired transformations efficiently.

4. Environmental Implications

Another area of interest involves the environmental impact of the chlorinated compounds:

  • Many chlorinated organic compounds undergo various biodegradation processes. Understanding these pathways for 5-Chloro-1,3-benzothiazol-2-amine is crucial for assessing its environmental fate.
  • Researching how such compounds behave in different conditions may lead to better approaches in the management of chemical pollutants.

5. Future Directions

Given its structural attributes, the future of 5-Chloro-1,3-benzothiazol-2-amine could lead to:

  • Enhanced derivatives that exhibit improved therapeutic efficacy.
  • Potential advancements in the field of agrochemicals to protect crops from pests while minimizing environmental impact.

In conclusion, 5-Chloro-1,3-benzothiazol-2-amine not only stands out in the realm of chemical compounds for its structural uniqueness but also for its wide array of applications and implications in both health and environmental sciences. Its exploration signifies a vibrant area of ongoing research that could yield significant benefits in the future.

Synonyms
2-Amino-5-chlorobenzothiazole
20358-00-3
2-Benzothiazolamine, 5-chloro-
5-CHLORO-2-BENZOTHIAZOLAMINE
BENZOTHIAZOLE, 2-AMINO-5-CHLORO-
NSC 56970
3LL9WL723B
NSC-56970
DTXSID60174271
5-CHLORO-2-BENZOTHIAZOLYLAMINE
DTXCID6096762
2-Benzothiazolamine, 5-chloro-(9CI)
451-710-6
606-533-0
RefChem:534508
5-chloro-1,3-benzothiazol-2-amine
5-chlorobenzo[d]thiazol-2-amine
MFCD00205355
2-AMINO-5-CHLOROBENZO[D]THIAZOLE
EN300-29388
5-chlorobenzothiazole-2-ylamine
5-Chloro-benzothiazol-2-ylamine
UNII-3LL9WL723B
NSC56970
(chloro-benzothiazolyl)-amine
SCHEMBL482340
SCHEMBL29944901
AVVSRALHGMVQQW-UHFFFAOYSA-N
BDBM626130
SBB014311
STK344963
AKOS000111199
AB04766
CCG-274024
CS-W019017
FS-3154
SY038031
DB-005176
ST4134048
A3177
NS00026597
358A003
A814483
Q27257553
Z228584306