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5-Chloro-1,3-benzoxazole

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Identification
Molecular formula
C7H4ClNO
CAS number
3879-16-3
IUPAC name
5-chloro-1,3-benzoxazole
State
State
Solid at room temperature, typically found in crystalline form.
Melting point (Celsius)
47.00
Melting point (Kelvin)
320.15
Boiling point (Celsius)
285.00
Boiling point (Kelvin)
558.15
General information
Molecular weight
155.57g/mol
Molar mass
155.5560g/mol
Density
1.4800g/cm3
Appearence

5-Chloro-1,3-benzoxazole is an off-white to pale yellow crystalline solid. It is usually encountered as fine crystals or a powder.

Comment on solubility

Solubility of 5-chloro-1,3-benzoxazole

5-chloro-1,3-benzoxazole is a compound whose solubility characteristics are quite fascinating. Understanding its solubility can offer insight into its behavior in various chemical environments.

  • Water Solubility: 5-chloro-1,3-benzoxazole exhibits limited solubility in water. This is largely attributed to its organic structure, which includes both aromatic and heterocyclic components that do not favor hydrogen bonding with water molecules.
  • Solubility in Organic Solvents: The compound is generally more soluble in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO). This is due to its lipophilic regions, which interact favorably with non-polar or weakly polar solvents.
  • Effect of pH: The solubility can also be influenced by the pH of the solution. Although it does not ionize significantly, slight alterations in pH can affect the solvation dynamics of the compound.

As with many heterocyclic compounds, the solubility of 5-chloro-1,3-benzoxazole can be described as moderately challenging due to its chemical structure, necessitating specific conditions to facilitate its dissolution. This characteristic is crucial when considering its applications and reactivity in chemical reactions.

Overall, the solubility of 5-chloro-1,3-benzoxazole reveals the intriguing balance between its hydrophobic and polar components, influencing its practical use in various chemical environments.

Interesting facts

Interesting Facts about 5-chloro-1,3-benzoxazole

5-chloro-1,3-benzoxazole is a fascinating compound that belongs to the benzoxazole family, characterized by its unique structure and notable chemical properties. Here are some interesting aspects of this intriguing substance:

  • Structural Significance: The compound contains a chloro group that enhances its reactivity and has implications in various organic synthesis pathways.
  • Applications: It is primarily used in the field of pharmaceuticals and agrochemicals. Its derivatives often exhibit antimicrobial, antifungal, and anti-inflammatory properties, making them valuable for drug development.
  • Fluorescent Properties: Compounds like 5-chloro-1,3-benzoxazole are sometimes studied for their unique *fluorescent* properties, which can be harnessed for imaging applications in biological systems.
  • Synthetic Versatility: The synthesis of this compound often serves as a model for teaching organic chemistry techniques, showcasing methods like cyclization and substitution reactions.
  • Research Interest: The scientific community remains interested in benzoxazole derivatives due to their promising activity in medicinal chemistry and materials science.

In summary, 5-chloro-1,3-benzoxazole is more than just a simple organic compound; it is a crucial player in the development of new therapeutic agents and continues to be a topic of much research in chemistry.

Synonyms
5-Chlorobenzoxazole
17200-29-2
BENZOXAZOLE, 5-CHLORO-
NSC 24984
BRN 0971560
DTXSID40169201
DTXCID5091692
626-358-3
5-chloro-1,3-benzoxazole
MFCD00216939
NSC-24984
5-chlorobenzo[d]oxazole
NSC24984
Maybridge1_004177
5-Chlorobenzoxazole, 95%
7MVD6UG5G2
SCHEMBL207390
SCHEMBL593252
SCHEMBL29941475
HMS553F21
VWMQXAYLHOSRKA-UHFFFAOYSA-N
GEO-00657
JFD 01498
SBB017040
AKOS005203449
CS-W002531
FS-1779
SY018748
DB-043882
C3509
ST50824416
EN300-387816