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5-Chloro-1,3-benzoxazole-2-thiol

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Identification
Molecular formula
C7H4ClNOS
CAS number
35854-78-5
IUPAC name
5-chloro-1,3-benzoxazole-2-thiol
State
State

This compound is typically a solid at room temperature, exhibiting stability and a crystalline structure that is characteristic of many aromatic compounds with heterocyclic elements.

Melting point (Celsius)
162.00
Melting point (Kelvin)
435.15
Boiling point (Celsius)
420.00
Boiling point (Kelvin)
693.15
General information
Molecular weight
187.63g/mol
Molar mass
187.6300g/mol
Density
1.7160g/cm3
Appearence

5-Chloro-1,3-benzoxazole-2-thiol appears as a pale yellow crystalline solid. It is often recognized by its distinct yellow coloration and is typically available in a powder form that may agglomerate into larger crystals over time.

Comment on solubility

Solubility of 5-chloro-1,3-benzoxazole-2-thiol

The solubility of 5-chloro-1,3-benzoxazole-2-thiol can be intriguing due to its unique chemical structure. Understanding its solubility is essential for various applications, especially in chemical synthesis and pharmaceutical formulations. Here are a few key points regarding its solubility:

  • Polarity: Due to the presence of the thiol (-SH) functional group, this compound may exhibit increased polarity, potentially enhancing its solubility in polar solvents.
  • Solvent Compatibility: 5-chloro-1,3-benzoxazole-2-thiol could be soluble in various organic solvents, such as methanol, ethanol, or acetone, making it versatile for laboratory use.
  • pH Dependence: The solubility of the thiol group may also be affected by the pH of the solution; in acidic conditions, it could be more soluble due to protonation.
  • Temperature Influence: As with many compounds, an increase in temperature may lead to enhanced solubility, which is crucial during reactions that require solubilization.

Investigating the solubility of 5-chloro-1,3-benzoxazole-2-thiol in various solvents helps chemists understand its behavior and applications better. Always remember, “The solubility can often reveal the reactivity!”

Interesting facts

Interesting Facts about 5-Chloro-1,3-benzoxazole-2-thiol

5-Chloro-1,3-benzoxazole-2-thiol is a fascinating compound belonging to the class of benzoxazoles, which are characterized by their fused ring structure. This compound has garnered attention in various fields for several noteworthy reasons:

  • Pharmaceutical Relevance: Compounds containing the benzoxazole moiety often exhibit significant biological activity. 5-Chloro-1,3-benzoxazole-2-thiol has potential applications in drug discovery, particularly due to its antimicrobial and anti-inflammatory properties.
  • Versatile Derivatives: The sulfur atom in the thiol group lends reactivity to this compound, allowing for the synthesis of diverse derivatives that can be tailored for specific chemical applications.
  • Functional Group Importance: Thiol groups are known for their ability to form disulfide bonds, making 5-chloro-1,3-benzoxazole-2-thiol interesting for studies related to protein interactions and enzyme functions.
  • Environmental Applications: This compound is also being explored for use in environmental chemistry, especially in the remediation of heavy metals due to its chelating properties.
  • Analytical Techniques: Researchers frequently employ various analytical techniques, such as NMR and mass spectrometry, to study the properties and behavior of this compound, expanding our understanding of its chemical landscape.

As we continue to study 5-chloro-1,3-benzoxazole-2-thiol, we unearth its potential, solidifying its place as a compound of interest in both academic and industrial realms. Its unique structure and properties make it a vital component in advancing research across a variety of scientific disciplines.