Interesting facts
Interesting Facts about 5-Chloro-2-hydroxy-N-phenyl-benzamide
5-Chloro-2-hydroxy-N-phenyl-benzamide, commonly referred to in the scientific community by its systematic name, is a fascinating compound that has garnered attention due to its diverse applications and intriguing properties. Here are some interesting facts about this compound:
- Pharmaceutical Relevance: This compound is often studied for its potential as a pharmaceutical agent, particularly in the realm of analgesics and anti-inflammatory drugs. Its structure allows for the modulation of biological activity, making it a valuable candidate in drug design.
- Chlorine Substitution: The presence of a chlorine atom at the 5-position of the benzamide moiety is significant. Chlorine is known to enhance the lipophilicity of compounds, which can improve their permeability in biological systems.
- Hydroxyl Group Importance: The 2-hydroxy group plays a crucial role in hydrogen bonding interactions, potentially enhancing the compound's solubility and biological efficacy. This feature could also contribute to the compound's stability in different pH environments.
- Structure-Activity Relationship (SAR): Understanding the SAR of this compound can lead to insights on how structural modifications affect its biological properties. This is essential in medicinal chemistry for optimizing drug efficacy and reducing side effects.
- Research Interests: Ongoing studies are examining its roles beyond pharmaceuticals, including applications in materials science and organic synthesis. The reactivity of benzamide derivatives continues to be a rich area of exploration for chemists.
In summary, 5-chloro-2-hydroxy-N-phenyl-benzamide is more than just a chemical entity; it is a compound that represents a myriad of possibilities in medicinal chemistry and research. As the field evolves, the insights drawn from compounds like this will undoubtedly contribute to advancements in various scientific domains.
Synonyms
5-Chlorosalicylanilide
4638-48-6
CHLOROSALICYLANILIDE
WR 13084
EINECS 225-065-4
QI22Q9QE3I
BRN 2216133
DTXSID9037749
AI3-50091
UNII-QI22Q9QE3I
NSC-402600
DTXCID7017749
3-12-00-00945 (Beilstein Handbook Reference)
NSC 402600
WR-13084
inchi=1/c13h10clno2/c14-9-6-7-12(16)11(8-9)13(17)15-10-4-2-1-3-5-10/h1-8,16h,(h,15,17
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5-Chloro-2-hydroxy-N-phenylbenzamide
Benzamide, 5-chloro-2-hydroxy-N-phenyl-
Salicylanilide, 5-chloro-
5-Chloro-2-hydroxy-N-phenyl-benzamide
CHEMBL1892375
NSC 402600; WR 13084
5-Chlorosalicyclanilide
MFCD00002320
5-Chlorsalicylanilid
5-Chlorosalicyanilide
Enamine_005183
Oprea1_670145
SCHEMBL538439
HMS1408L13
EAA63848
Tox21_301637
BDBM50430187
NSC402600
AKOS000121411
IDI1_007770
NCGC00164110-01
NCGC00255613-01
BS-23387
CAS-4638-48-6
NS00031601
EN300-17072
D89228
AB00758428-01
SR-01000390630
SR-01000390630-1
Q27287275
Z56871780
Solubility of 5-chloro-2-hydroxy-N-phenyl-benzamide
The solubility of 5-chloro-2-hydroxy-N-phenyl-benzamide can be influenced by several factors, making its behavior in different solvents particularly interesting. Understanding these properties is crucial for applications involving this compound.
Factors Affecting Solubility:
Expected Solubility Characteristics:
In practical terms:
As quoted from solubility studies, "Chemical stability often correlates with solubility characteristics, where increased solubility in a suitable solvent may enhance reactivity." Thus, for 5-chloro-2-hydroxy-N-phenyl-benzamide, careful consideration is needed when selecting a medium for reaction or storage.