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5-Chloro-2-methyl-3-isothiazolinone

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Identification
Molecular formula
C4H4ClNOS
CAS number
26172-55-4
IUPAC name
5-chloro-2-methyl-isothiazol-3-one
State
State

At room temperature, it typically exists in a liquid state.

Melting point (Celsius)
32.00
Melting point (Kelvin)
305.15
Boiling point (Celsius)
213.00
Boiling point (Kelvin)
486.15
General information
Molecular weight
149.61g/mol
Molar mass
149.6100g/mol
Density
1.2920g/cm3
Appearence

5-Chloro-2-methyl-3-isothiazolinone is generally found as a clear to yellow liquid.

Comment on solubility

Solubility of 5-chloro-2-methyl-isothiazol-3-one

5-chloro-2-methyl-isothiazol-3-one is a compound that exhibits unique solubility characteristics. Understanding its solubility can provide insights into its applications and efficacy in various environments. Here are a few key points regarding its solubility:

  • Solvent Compatibility: This compound is typically soluble in organic solvents such as methanol and ethanol, which makes it useful in formulations where these solvents are present.
  • Aqueous Solubility: The solubility of 5-chloro-2-methyl-isothiazol-3-one in water is relatively limited, indicating that it may not readily dissolve in typical aqueous systems.
  • pH Influence: The solubility can be influenced by pH levels; in more acidic conditions, the compound may exhibit improved solubility.
  • Applications: Due to its solubility profile, this compound is often utilized in biocide formulations, where it can be effectively delivered in specific solvent systems.

In summary, while 5-chloro-2-methyl-isothiazol-3-one demonstrates solubility in organic solvents, its limited aqueous solubility indicates that careful consideration must be made when utilizing it in water-based applications. As stated, “The solvent chosen can significantly affect the behavior and effectiveness of chemical compounds.” This highlights the critical importance of solubility in chemical applications.

Interesting facts

Interesting Facts about 5-Chloro-2-Methyl-Isothiazol-3-One

5-Chloro-2-methyl-isothiazol-3-one, commonly known as CMIT, is a fascinating chemical compound with various applications, particularly in industrial and biocidal products. Here are some intriguing aspects you might find interesting:

  • Biocidal Properties: CMIT is widely employed for its potent biocidal action. It is effective against a broad spectrum of microorganisms, making it a preferred choice in various formulations to prevent microbial growth.
  • Preservative Use: This compound is often used as a preservative in cosmetics, personal care products, and industrial materials, helping to extend their shelf life and ensure safety for consumers.
  • Environmental Considerations: While CMIT is effective in killing bacteria and fungi, it is essential to handle it with care due to its potential environmental impact. Its use often requires adherence to strict regulatory guidelines to minimize risks.
  • Mechanism of Action: The isothiazolone ring in CMIT contributes significantly to its ability to disrupt cellular processes in microorganisms, which is crucial for its performance as a biocide.
  • Synergy with Other Compounds: CMIT is frequently used in combination with other biocides to enhance efficacy and broaden the antimicrobial spectrum, showcasing the importance of chemical synergy in formulation chemistry.
  • Health and Safety: Users must be aware that CMIT can be sensitizing and may cause allergic reactions in some individuals, highlighting the importance of safety measures in handling and application.

As a vital component in many products, the study and application of 5-chloro-2-methyl-isothiazol-3-one illustrate the balance between efficacy and safety in modern chemistry.

For aspiring chemists, understanding compounds like CMIT offers invaluable insights into the complexities of biocides and the critical role they play in public health and safety.

Synonyms
5-Chloro-2-methyl-4-isothiazolin-3-one
26172-55-4
Methylchloroisothiazolinone
CMIT
5-Chloro-2-methyl-3(2H)-isothiazolone
5-Chloro-2-methyl-3-isothiazolone
Kathon CG 5243
3(2H)-Isothiazolone, 5-chloro-2-methyl-
5-chloro-N-methylisothiazolone
5-chloro-2-methylisothiazolin-3-one
5-chloro-n-methylisothiazolin-3-one
HS 818
n-methyl-5-chloroisothiazolone
DEL7T5QRPN
4-ISOTHIAZOLIN-3-ONE, 5-CHLORO-2-METHYL-
N-Methyl-5-chloroisothiazolin-3-one
DTXSID9034286
5-chloro-2-methyl-3(2H)-isothiazolinone
DTXCID7014286
HS-818
RefChem:818544
247-500-7
Chloromethylisothiazolinone
5-Chloro-2-methyl-2H-isothiazol-3-one
MFCD00792550
5-chloro-2-methyl-1,2-thiazol-3-one
5-chloro-2-methyl-isothiazol-3-one
5-chloro-2-methyl-4-isothiazoline-3-one
CHEBI:53621
2,3-Dihydro-2-methyl-3-oxo-5-chloroisothiazole
5-Chloro-2-methyl-4-isothiazolin-3-one, tech grade, >14% in water. CMI/MI >2.0
NCGC00181041-01
Bioace
5-chloro-2-methyl-1,2-thiazol-3(2H)-one
5-Chloro-2-methyl-3-isothiazolone (~90%)
Kathon IXE
5-chloro-2-methyl-2,3-dihydro-1,2-thiazol-3-one
5-chloro-2-methylisothiazol-3(2h)-one
5-Chloro-2-methyl-4-isothiazolin-3-one 100 microg/mL in Acetonitrile
N-Methyl-5-chloroisothiazolone (5-Chloro-2-methyl-4-isothiazolin-3-one)
CAS-26172-55-4
A 33 (bactericide)
UNII-DEL7T5QRPN
HS 818 (antiseptic)
EINECS 247-500-7
BRN 1210149
Isothiazolinones
5-Chloro-2-methyl-4-isothiazolin-3-one D3 (methyl D3)
5-Chloro-2-methyl-4-isothiazolin-3-one (CMI)
2-Methyl-5-chloro-3-isothiazolone
2-Methyl-5-chloroisothiazolin-3-one
5-chloro-2-methyl-2h-isothiazolin-3-one
T 360
SCHEMBL20686
CHEMBL1738962
HSDB 8270
MSK2157
EDC61134
Tox21_112689
Tox21_300199
AKOS006230760
CS-W022348
DB14197
FC20025
GS-3223
HY-W041608
METHYLCHLOROISOTHIAZOLINONE [II]
METHYLCHLOROISOTHIAZOLINONE [MI]
5-Chloro-2-methyl-4-isothiazol-3-one
5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE (ACTIVE INGREDIENT >14%, CMI/MI 2.5 - 4.0)
NCGC00181041-02
NCGC00254127-01
55965-84-9 CMIT, MIT
METHYLCHLOROISOTHIAZOLINONE [VANDF]
2682-20-4 MIT
5-Chloro-2-methyl-isothiazol-3(2H)-one
METHYLCHLOROISOTHIAZOLINONE [MART.]
DB-007017
METHYLCHLOROISOTHIAZOLINONE [WHO-DD]
NS00000256
5-CHLOR-2-METHYL-4-ISOTHIAZOLIN-3-ONE
H10371
SBI-0654074.0001
EN300-7409393
F209044
Q204121
SR-01000944864
SR-01000944864-1
Z2417817741
5-Chloro-2-methyl-4-isothiazolin-3-one (CMI/MI > 2.0)
5-Chloro-2-methyl-3-isothiazolone - Active Ingredient >14%, CMI/MI 2.5 - 4.0