5-Chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole

Identification

Molecular formula

C₁₃H₁₅ClN₂

CAS number

2748327-88-2

IUPAC name

5-chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole

State

At room temperature, 5-chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole remains in a solid state due to its crystalline structure. It is typically stored in airtight containers to prevent any moisture absorption, which could potentially alter its appearance and reduce its quality.

Melting point (Celsius)

175.30

Melting point (Kelvin)

448.50

Boiling point (Celsius)

401.40

Boiling point (Kelvin)

674.60

General information

Molecular weight

232.72g/mol

Molar mass

232.7150g/mol

Density

1.3100g/cm³

Appearence

5-Chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole is a compound that typically appears as a crystalline solid. Its color can range from white to off-white, depending on its purity. The crystalline nature can be observed under a microscope, where the individual crystals reflect light and may show a somewhat glossy appearance.

Comment on solubility

Solubility of 5-chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole

The solubility of 5-chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole can be influenced by several factors, including its molecular structure and functional groups. This compound exhibits some unique characteristics that can impact its solubility:

Polarity: Due to the presence of the 1-methylpyrrolidin-2-yl group, this compound may have moderate to high polarity. Polar compounds typically show solubility in polar solvents.
Intermolecular Interactions: The ability of this compound to form hydrogen bonds can enhance its solubility in water and other polar solvents.
Solvent Choice: Solubility tends to vary widely in different solvents. For example, it may be more soluble in organic solvents like ethanol or DMSO compared to water.
Temperature: Increasing temperature can often lead to an increase in solubility, particularly for solid compounds.

In conclusion, the solubility of 5-chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole is a multi-faceted subject, highly dependent on the intermolecular interactions, choice of solvent, and environmental conditions. Understanding these factors can aid in optimizing conditions for practical applications.

Interesting facts

Exploring 5-Chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole

5-Chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole is a fascinating compound that belongs to the class of indole derivatives, which are known for their diverse biological activities. Here are some interesting facts that highlight its significance:

Structural Diversity: This compound showcases the unique structural features of indole, a bicyclic structure composed of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring.
Pharmacological Potential: Compounds like 5-chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole have been studied for their potential applications in various therapeutic areas, including neuropharmacology and antidepressant activity.
Synthetic Route: The synthesis of this compound can involve various techniques, including modification of existing indole structures through halogenation and the incorporation of aliphatic amines, illustrating the complexity of organic synthesis.
Research Insight: As noted in several studies, the introduction of a halogen atom (in this case, chlorine) can enhance the biological activity of indole derivatives, making them potential candidates for drug development.

Overall, the exploration of 5-chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole represents a crucial step in understanding the intricate relationships between chemical structure and biological function. The ongoing research into its properties and applications could uncover new therapeutic avenues in medicinal chemistry.

Synonyms

5-chloro-3-(1-methylpyrrolidin-2-yl)-1H-indole

19134-31-7

5-Chloro-3-(1-methyl-2-pyrrolidinyl)-1H-indole

BRN 0524760

5-Chloro-3-(1-methyl-2-pyrrolidinyl)indole

INDOLE, 5-CHLORO-3-(1-METHYL-2-PYRROLIDINYL)-

DTXSID20940737