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Indolinone derivative

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Identification
Molecular formula
C18H15ClN2O
CAS number
Not available
IUPAC name
5-chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]indolin-2-one
State
State

At room temperature, this compound is typically in a solid state and appears as a crystalline powder.

Melting point (Celsius)
223.00
Melting point (Kelvin)
496.15
Boiling point (Celsius)
475.00
Boiling point (Kelvin)
748.15
General information
Molecular weight
312.78g/mol
Molar mass
312.7770g/mol
Density
1.4500g/cm3
Appearence

The compound appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 5-chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]indolin-2-one

The solubility of the compound 5-chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]indolin-2-one (C18H15ClN2O) can vary significantly based on the solvent used. Generally, the following points can be considered:

  • Polar Solvents: The presence of the chlorine atom and the nitrogen atoms suggest that this compound may have some polar characteristics. Therefore, it might exhibit solubility in polar solvents, albeit possibly limited due to its large organic structure.

  • Non-polar Solvents: Given the substantial hydrocarbon portion of the molecule, it is likely to be more soluble in non-polar solvents such as chloroform or dichloromethane.

  • Hydrogen Bonding: The potential for hydrogen bonding involving the nitrogen atoms might enhance solubility in specific polar protic solvents, though steric hindrance from the methyl groups could affect this.

  • Temperature Influence: Alterations in temperature can also impact solubility, as increased temperatures typically result in increased solubility for many organic compounds.

In summary, while the solubility profile for 5-chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]indolin-2-one presents some interesting opportunities for dissolution, the specific conditions and solvent choice will greatly define the outcome. As is often the case with complex organic molecules, thorough experimentation is essential to precisely determine solubility characteristics.

Interesting facts

Interesting Facts about 5-chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]indolin-2-one

5-chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]indolin-2-one is a remarkable compound belonging to the indole class of organic compounds, widely studied for its diverse biological properties. Here are some intriguing aspects of this compound:

  • Diverse Applications: This compound has attracted attention in medicinal chemistry due to its potential applications in drug development, particularly as a scaffold for creating new pharmaceuticals.
  • Biological Significance: Indolinones, such as this compound, are often investigated for their anticancer properties and ability to inhibit various enzymes. Researchers explore their capabilities to treat different malignancies.
  • Structure-Activity Relationships: The inclusion of the 3,5-dimethyl-1H-pyrrol-2-yl group in its structure complicates the analysis of how such modifications affect biological activity. Scientists often utilize structure-activity relationship (SAR) studies to understand these influences better.
  • Chlorine's Role: The presence of chlorine in its molecular structure plays a crucial role in enhancing the compound's lipophilicity, which can improve its biological activity by facilitating cellular uptake.
  • Research Potential: Continued research is vital for discovering new properties, exploring synthesis methods, and finding innovative uses in the fields of pharmaceuticals and agrochemicals.

This compound epitomizes the intersection of organic chemistry and pharmacology, encouraging chemists to explore uncharted territories of molecular biology and medicinal uses while emphasizing the significance of small structural changes on biological functionality.

Synonyms
su5614
5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydroindol-2-one
(3Z)-5-chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
5-Chloro-3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydroindol-2-one
5-CHLORO-3-(3,5-DIMETHYL-1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-INDOL-2-ONE
SCHEMBL2126784
DTXSID201145213
BCP16040
AKOS026750434
SB64044
SU-5614;SU 5614
F31185
5-chloro-3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylene]-1,3-dihydro-2 H-indol-2-one