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5-Chloro-3-(morpholinomethyl)-1,3-benzoxazol-2-one

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Identification
Molecular formula
C12H13ClN2O3
CAS number
122652-06-4
IUPAC name
5-chloro-3-(morpholinomethyl)-1,3-benzoxazol-2-one
State
State
Typically a crystalline solid at room temperature, which can be stored under dry and cool conditions to maintain its integrity. It is usually handled in a laboratory environment with appropriate safety measures.
Melting point (Celsius)
194.00
Melting point (Kelvin)
467.15
Boiling point (Celsius)
458.10
Boiling point (Kelvin)
731.25
General information
Molecular weight
268.70g/mol
Molar mass
268.7000g/mol
Density
1.4479g/cm3
Appearence

5-Chloro-3-(morpholinomethyl)-1,3-benzoxazol-2-one typically appears as a crystalline solid. Its color can vary depending on the specific conditions and impurities present during synthesis. It is important to handle the compound in an appropriate manner, often under specific storage conditions to maintain its stability and purity.

Comment on solubility

Solubility of 5-chloro-3-(morpholinomethyl)-1,3-benzoxazol-2-one

The solubility of 5-chloro-3-(morpholinomethyl)-1,3-benzoxazol-2-one can be quite intriguing due to its unique structure. Understanding its solubility is essential for applications in pharmaceuticals and other chemical industries. Here are some key points to consider:

  • Polarity: The presence of the morpholinomethyl group contributes to the overall polarity of the molecule, which can enhance its solubility in polar solvents.
  • Hydrogen Bonding: The potential for hydrogen bonding in the functional groups can also affect solubility, especially in water where interactions with solvent molecules are crucial.
  • Solvent Compatibility: This compound might show solubility in a variety of organic solvents such as DMSO and ethanol, while potentially exhibiting low solubility in nonpolar solvents.
  • Temperature Dependence: The solubility may vary with temperature; generally, increasing the temperature enhances solubility for many organic compounds.
  • pH Sensitivity: The solubility may also be influenced by the pH of the solution, where changes in the ionic state of the morpholine group can alter solubility behavior.

In conclusion, while the solubility profile of 5-chloro-3-(morpholinomethyl)-1,3-benzoxazol-2-one is complex and influenced by multiple factors, it is essential for applications involving this intriguing compound to conduct detailed solubility testing in various solvents under controlled conditions.

Interesting facts

Interesting Facts about 5-Chloro-3-(Morpholinomethyl)-1,3-benzoxazol-2-one

5-Chloro-3-(morpholinomethyl)-1,3-benzoxazol-2-one is a fascinating compound that blends structural complexity with potential applications in various fields. Below are some intriguing aspects of this compound:

  • Unique Structure: This compound features a benzoxazole ring fused with a morpholino group, offering interesting electronic properties and the possibility of activity as an organic semiconductor.
  • Pharmacological Potential: Compounds with similar structures have been studied for their biological activities. Some derivatives exhibit anti-cancer and anti-inflammatory properties, making them significant in medicinal chemistry.
  • Chlorine Substitution: The presence of the chlorine atom in the structure can enhance the compound's lipophilicity, which may contribute to its ability to penetrate biological membranes, a key factor in drug design.
  • Synthetic Versatility: The ability to modify the morpholino group adds versatility to this compound, allowing for the design of various analogs that could possess different biological activities.
  • Research Applications: As a benzoxazole derivative, this compound serves as a valuable template for the development of new pharmacological agents, with research ongoing in fields such as cancer therapy and neuropharmacology.

In the words of a prominent chemist, "Structure is the master key to activity." This sentiment is particularly relevant for 5-chloro-3-(morpholinomethyl)-1,3-benzoxazol-2-one, wherein its structural attributes may unlock a world of potential in scientific research.

Overall, the study of this compound not only enriches our understanding of organic chemistry but also points towards future innovations in medicinal applications.

Synonyms
16376-61-7
5-Chloro-3-(4-morpholinylmethyl)-2(3H)-benzoxazolone
CHEMBL319405
N-(Morpholinomethyl)chlorzoxazone
NSC 108209
BRN 1219941
5-Chloro-3-(morpholinomethyl)-2-benzoxazolinone
Morfolinometylo-5-chloro-benzoksazolon-2 [Polish]
2-Benzoxazolinone, 5-chloro-3-(morpholinomethyl)-
NSC108209
5-Chloro-3-morpholin-4-ylmethyl-3H-benzooxazol-2-one
5-chloro-3-(morpholin-4-ylmethyl)-1,3-benzoxazol-2-one
Morfolinometylo-5-chloro-benzoksazolon-2
Oprea1_267026
2-Benzoxazolinone, 5-chloro-3-(morpholinomethyl)- (8CI)
DTXSID10167658
2(3H)-BENZOXAZOLONE, 5-CHLORO-3-(4-MORPHOLINYLMETHYL)-
BDBM50290814
STK529342
AKOS000552719
NSC-108209
DS-003319
ST50284805
5-chloro-3-(morpholin-4-ylmethyl)-3-hydrobenzoxazol-2-one
2(3H)-BENZOXAZOLONE,5-CHLORO-3-(4-MORPHOLINYLMETHYL)-
5-chloro-3-(4-morpholinylmethyl)-1,3-benzoxazol-2(3H)-one
5-chloro-3-(morpholin-4-ylmethyl)-1,3-benzoxazol-2(3H)-one