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5-Chloro-3-phenyl-2-[4-(pyrrolidin-1-ylethoxy)phenyl]-1H-indole

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Identification
Molecular formula
C28H27ClN2O
CAS number
91573-81-2
IUPAC name
5-chloro-3-phenyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-indole
State
State

The compound is generally in a solid state at room temperature, usually as a crystalline powder.

Melting point (Celsius)
180.00
Melting point (Kelvin)
453.00
Boiling point (Celsius)
640.00
Boiling point (Kelvin)
913.00
General information
Molecular weight
426.99g/mol
Molar mass
426.9460g/mol
Density
1.3000g/cm3
Appearence

The compound appears as a white to off-white solid, typically found in crystalline powder form. It may have a slight odor characteristic of organic compounds.

Comment on solubility

Solubility of 5-chloro-3-phenyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-indole

Understanding the solubility characteristics of 5-chloro-3-phenyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-indole is crucial for its application in various chemical processes. This compound exhibits distinctive solubility properties due to its complex structure, which combines multiple functional groups. Here are some key points regarding its solubility:

  • Solvent Dependency: The solubility of this compound may vary significantly depending on the solvent used. Polar solvents such as water may not dissolve it effectively, while non-polar solvents might be more suitable.
  • Functional Groups Influence: The presence of the indole and ether motifs can enhance its solubility in organic solvents. The –O– group could facilitate interactions with similar polar solvents.
  • Temperature Effects: Like many organic compounds, solubility is temperature-dependent. Generally, an increase in temperature can lead to increased solubility.
  • pH Considerations: The pH of the solution can also impact solubility. If the compound can undergo protonation, its solubility may improve in acidic conditions.

Overall, it is essential to explore these factors experimentally to determine the optimal conditions for dissolving 5-chloro-3-phenyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-indole. As noted in various studies, understanding the nuances of solubility not only aids in formulation development but also enhances its effectiveness in targeted applications.

Interesting facts

Interesting Facts about 5-Chloro-3-phenyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-indole

This compound is a fascinating member of the indole family, showcasing a unique structure that contributes to its intriguing properties and potential applications. Here are some compelling aspects to consider:

  • Pharmacological Potential: Compounds like this one often play a crucial role in medicinal chemistry. Indoles are known for their diverse biological activities, which might include anti-cancer or anti-inflammatory effects, making them valuable in drug design.
  • Complex Structure: The incorporation of a chloro group and a pyrrolidine moiety adds layers of complexity, which can enhance the compound's ability to interact with biological targets through various mechanisms.
  • Research Significance: The study of indole derivatives is vibrant in scientific literature, as they can lead to novel therapeutic agents. This compound’s specific structure may provide insights or pathways for further development in pharmaceuticals.
  • Versatile Synthesis: Compounds containing indole rings can often be synthesized using a variety of methods, including cyclization reactions and substitution techniques, contributing to their accessibility in the lab.
  • Structure-Activity Relationship (SAR): Scientists often explore how changes in the compound's structure affect its biological activity. Understanding these relationships can be pivotal for optimizing therapeutic efficacy.

In summary, 5-chloro-3-phenyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-indole stands at a crossroads of chemistry and biology. Its unique composition invites further investigation into its potential utility in pharmacology as well as its fundamental chemical behavior.

Synonyms
INDOLE, 5-CHLORO-3-PHENYL-2-(p-(2-(1-PYRROLIDINYL)ETHOXY)PHENYL)-
14036-30-7
BRN 1507613
Indole, 5-chloro-3-phenyl-2-[p-[2-(1-pyrrolidinyl)ethoxy]phenyl]-
5-Chloro-3-phenyl-2-p-(beta-pyrrolidinoethoxy)phenylindole
5-Chloro-3-phenyl-2-(p-(2-(1-pyrrolidinyl)ethoxy)phenyl)indole
YA8WWG623Z
5-21-04-00296 (Beilstein Handbook Reference)
DTXSID50161317
1H-Indole, 5-chloro-3-phenyl-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-
5-Chloro-3-phenyl-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-1H-indole