Skip to main content

Chloroquine dihydrochloride

ADVERTISEMENT
Identification
Molecular formula
C18H26ClN3 · 2HCl
CAS number
50-63-5
IUPAC name
5-chloro-7-[[3-(diethylamino)propylamino]methyl]quinolin-8-ol;dihydrochloride
State
State

At room temperature, chloroquine dihydrochloride exists as a solid. Its crystalline form is stable under standard conditions, which makes it easy to store and handle as an oral or injectable formulation in medical applications.

Melting point (Celsius)
193.00
Melting point (Kelvin)
466.15
Boiling point (Celsius)
510.00
Boiling point (Kelvin)
783.15
General information
Molecular weight
399.82g/mol
Molar mass
376.6970g/mol
Density
1.5870g/cm3
Appearence

Chloroquine dihydrochloride typically appears as a white crystalline powder. It is odorless and has a bitter taste, commonly associated with its use as an antimalarial medication.

Comment on solubility

Solubility of 5-chloro-7-[[3-(diethylamino)propylamino]methyl]quinolin-8-ol; dihydrochloride

The solubility of 5-chloro-7-[[3-(diethylamino)propylamino]methyl]quinolin-8-ol; dihydrochloride is primarily influenced by its ionic nature due to the two hydrochloride groups. In general, here are some key points regarding its solubility:

  • Water Solubility: The presence of the dihydrochloride makes this compound more soluble in water compared to its base form. This allows for a greater ease of dissolution in polar solvents.
  • Organic Solvents: The solubility in organic solvents may vary; typically, compounds with larger alkyl groups, such as the diethylamino group, exhibit increased solubility in organic media.
  • pH Dependence: The solubility can change significantly with pH. In acidic conditions, the compound remains ionized, enhancing its solubility, whereas under neutral or basic conditions, the solubility may decrease due to reduced ionization.

In conclusion, this compound is generally highly soluble in aqueous solutions, especially at lower pH levels, making it suitable for various applications in biological systems. As a reminder, the solubility is subject to environmental conditions and the specific medium used.

Interesting facts

Interesting Facts about 5-Chloro-7-[[3-(diethylamino)propylamino]methyl]quinolin-8-ol Dihydrochloride

This compound, known for its unique structure and potential applications, belongs to the class of quinolinol derivatives. The intricate arrangement of atoms within its molecular framework contributes to its intriguing properties. Here are some noteworthy highlights:

  • Pharmacological Interest: Quinolinol derivatives have been widely studied for their biological activities. This specific compound may possess important pharmacological properties, making it of interest in medicinal chemistry.
  • Structure-Activity Relationship: The presence of the diethylamino group at the 3-position enhances the lipophilicity of the compound, influencing its ability to permeate biological membranes.
  • Applications: Compounds like this one have potential uses in developing therapies for various conditions, possibly including cancer and neurological disorders, due to their interaction with biological pathways.
  • Research Potential: Ongoing research may uncover additional functionalities of 5-chloro-7-[[3-(diethylamino)propylamino]methyl]quinolin-8-ol, solidifying its place in the field of drug discovery.

An insightful quote from one of the pioneers in medicinal chemistry sums it up quite well: "The future of pharmaceuticals lies in understanding the fine details of how compounds interact within the human body." This statement encapsulates the essence of studying complex compounds like this quinolinol derivative.

Overall, 5-chloro-7-[[3-(diethylamino)propylamino]methyl]quinolin-8-ol dihydrochloride stands as a testament to the fascinating world of organic chemistry, where structure meets profound biological significance.

Synonyms
Clamoxyquin hydrochloride
Clamoxyquin HCl
4724-59-8
Clamoxyquine hydrochloride
Clamoxyquin hydrochloride [USAN]
KAN 322
CLAMOXYQUIN DIHYDROCHLORIDE
UNII-SQ922M93PI
Clamoxyl (TN)
SQ922M93PI
CN-17,900-2B
PAA 3854
CN 17900-2 B
5-Chloro-7-(((3-(diethylamino)propyl)amino)methyl)-8-quinolinol dihydrochloride
PAA-3854
CI-433
Clamoxyquin Hydrochloride (USAN)
CN-17900-2B
NSC-20246
8-Quinolinol, 5-chloro-7-(((3-(diethylamino)propyl)amino)methyl)-, dihydrochloride
5-CHLORO-7-(3-DIETHYLAMINOPROPYL-AMINOMETHYL)-8-QUINOLINOL DIHYDROCHLORIDE
NSC20246
Clamoxyl parenteral
Clamoxyl G.A.
penamox
CI 433
5-chloro-7-[[3-(diethylamino)propylamino]methyl]quinolin-8-ol;dihydrochloride
NSC 20246
SCHEMBL634932
4724-59-8 (HCl)
D03529
Q27289344