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Clioquinol

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Identification
Molecular formula
C9H5ClINO
CAS number
130-26-7
IUPAC name
5-chloro-7-iodo-quinolin-8-ol
State
State

Clioquinol is typically a solid at room temperature.

Melting point (Celsius)
171.00
Melting point (Kelvin)
444.00
Boiling point (Celsius)
308.00
Boiling point (Kelvin)
581.00
General information
Molecular weight
305.50g/mol
Molar mass
305.4860g/mol
Density
2.0360g/cm3
Appearence

Clioquinol appears as a yellowish-white or pale yellow crystalline powder. It is practically odorless, and its appearance may vary slightly based on the specific formulation or method of preparation.

Comment on solubility

Solubility of 5-chloro-7-iodo-quinolin-8-ol

The solubility of 5-chloro-7-iodo-quinolin-8-ol (C9H5ClINO) can be influenced by various factors, including its molecular structure and the presence of functional groups. This compound features both chlorine and iodine substitutions, which can affect its solubility properties.

Key Points on Solubility:

  • Polarity: The presence of hydroxyl (-OH) groups increases polarity, potentially enhancing solubility in polar solvents, such as water.
  • Solubility in Organic Solvents: Compounds like quinolin-8-ol derivatives tend to exhibit better solubility in non-polar organic solvents, such as ethanol and acetone, due to hydrophobic interactions.
  • Temperature Dependency: Solubility can also vary with temperature, often increasing in warmer conditions.
  • Hydrogen Bonding: The ability to form hydrogen bonds can facilitate dissolution in polar solvents but may also create limitations in non-polar environments.

In summary, the solubility of 5-chloro-7-iodo-quinolin-8-ol is determined by its complex structure and the balance between hydrophilic and hydrophobic forces. As a result, one might describe it as moderately soluble in polar solvents while exhibiting greater solubility in organic solvents. Understanding these solubility characteristics is essential for effective application in various chemical processes.

Interesting facts

Interesting Facts About 5-Chloro-7-iodo-quinolin-8-ol

5-Chloro-7-iodo-quinolin-8-ol is a fascinating compound that falls within the quinoline class of organic compounds. Here are some intriguing facts:

  • Structural Significance: The presence of both chlorine and iodine in its structure makes this compound unique and opens avenues for its application in various fields, especially in medicinal chemistry.
  • Pharmacological Potential: Compounds like 5-chloro-7-iodo-quinolin-8-ol have been studied for their antimicrobial and antiviral properties, making them important in the search for new therapeutic agents.
  • Quinoline Derivatives: The quinoline moiety is a key structure in many biologically active molecules. This compound can serve as a building block for synthesizing a variety of other compounds with medicinal applications.
  • Synthesis: The synthesis of 5-chloro-7-iodo-quinolin-8-ol often involves multiple steps and can be an excellent example to study reaction mechanisms and strategies in organic synthesis.
  • Research Interest: Studies continue to explore the reactivity and interactions of this compound, particularly regarding its behavior in biological systems and potential pathways for drug development.

This compound not only highlights the complexity of organic chemistry but also underscores the importance of quinoline derivatives in advancing pharmaceutical science. As we uncover more about compounds like 5-chloro-7-iodo-quinolin-8-ol, we inch closer to innovative solutions in drug discovery.

Synonyms
clioquinol
130-26-7
5-Chloro-7-iodoquinolin-8-ol
Iodochlorhydroxyquin
5-Chloro-8-hydroxy-7-iodoquinoline
Chinoform
Chloroiodoquin
5-Chloro-7-iodo-8-quinolinol
Chloroiodoquine
Vioform
Iodochloroxyquinoline
Cliquinol
Iodochlorohydroxyquinoline
Chlorojodochin
Enteroquinol
Iodochloroquine
Iodochloroxine
Iodoenterol
5-Chloro-7-iodo-8-hydroxyquinoline
7-Iodo-5-chloroxine
Entero-Vioform
Iodochlorhydroxyquinoline
Iodoxyquinoline
Alchloquin
Barquinol
Budoform
Cifoform
Dermaform
Dioquinol
Domeform
Eczecidin
Enteroseptol
Enterozol
Enterseptol
Entrokin
Iodenterol
Lekosept
Mycoquin
Quinambicide
Rheaform
Amebil
Amoenol
Bactol
Emaform
Nioform
Rometin
Entero-Bioform
Iodochlorohydroxyquin
Hi-Enterol
Iodochlorhydroxyquinol
Hydriodide-enterol
Quin-O-Creme
Entero-Septol
Enterum locorten
5-Chloro-7-iodo-quinolin-8-ol
Domeform-HC
8-Quinolinol, 5-chloro-7-iodo-
7-Iodo-5-chloro-8-hydroxyquinoline
Clioquinolum
Chloro-8-hydroxyiodoquinoline
Quinoform (antiseptic)
Vioform n.n.r.
Quinoline, chloro-8-hydroxyiodo-
5-Chlor-7-jod-8-hydroxy-chinolin
Rheaform boluses
MFCD00006787
iodochlorhydroxyquinolone
NSC-3531
Chinoformum
Cliochinolum
7BHQ856EJ5
Enterovalodon
Alioform
DTXSID7022837
Enteritan
Jodchloroxychinolinum
Oralcer
CHEBI:74460
Corque
Cortin
Iodo
Iodochloroxychinolinum
Cremo-quin
Entero-bio form
Entero-Vioformio
Ala-Quin
UAD Lotion
NSC-74938
NCGC00016391-05
Cliochinolo
CAS-130-26-7
Cliochinolo [DCIT]
TG2-36-2
Caswell No. 193
Formtone-HC
Clioquinolum [INN-Latin]
DTXCID502837
loquinol
Vioformio
Hi-eneterol
Iodochlorhydroxyquin Cream
Vioform-Hydrocortisone Mild
SMR000058282
Rheaform Boluses (Veterinary)
CCRIS 6050
HSDB 6843
5-Chlor-7-jod-8-hydroxy-chinolin [German]
SR-01000002987
NSC 3531
EINECS 204-984-4
EPA Pesticide Chemical Code 024001
BRN 0153637
UNII-7BHQ856EJ5
Linolasept
Clioquinol [USP:INN:BAN]
Cloquinol
AI3-16451
Clioquinol (CQ)
component of Hyquin
NSC 74938
Clioquinol (Standard)
Nystaform (Salt/Mix)
Clioquinol (USP/INN)
CLIOQUINOL [INN]
component of Formtone-HC
component of Heb-Cort V
Prestwick0_000886
Prestwick1_000886
Prestwick2_000886
Prestwick3_000886
CLIOQUINOL [HSDB]
Formtone-HC (Salt/Mix)
CLIOQUINOL [VANDF]
CHEMBL497
EC 204-984-4
cid_2788
CLIOQUINOL [MART.]
SCHEMBL3967
CLIOQUINOL [USP-RS]
CLIOQUINOL [WHO-DD]
NCIOpen2_009062
PBT-1
Oprea1_438281
BSPBio_000672
BSPBio_002466
5-21-03-00294 (Beilstein Handbook Reference)
ksc-8-192
MLS000069389
MLS002454410
SPECTRUM1505114
SPBio_002891
BPBio1_000740
CLIOQUINOL [ORANGE BOOK]
component of Hyquin (Salt/Mix)
BDBM32188
Clioquinol - Bio-X trade mark
IODOCHLORHYDROXYQUIN [MI]
CLIOQUINOL [EP MONOGRAPH]
NSC3531
WLN: T66 BNJ GG II JQ
CLIOQUINOL [USP MONOGRAPH]
HMS1570B14
HMS1648J07
HMS2093I12
HMS2097B14
HMS2230I20
HMS3372J20
HMS3714B14
KUC105859N
Pharmakon1600-01505114
ALBB-031653
component of Cort-Quin (Salt/Mix)
Tox21_110416
Tox21_200291
HY-14603R
NSC759822
NYSTAFORM COMPONENT CLIOQUINOL
s4601
STK399761
5-chloro-8-hydroxy-7-iodo-quinoline
component of Heb-Cort V (Salt/Mix)
AKOS000120779
Tox21_110416_1
AC-6792
CCG-213339
DB04815
FC40594
FD10468
NSC-759822
SMP1_000073
IODOCHLORHYDROXYQUIN [GREEN BOOK]
NCGC00016391-01
NCGC00016391-02
NCGC00016391-03
NCGC00016391-04
NCGC00016391-06
NCGC00016391-07
NCGC00016391-08
NCGC00016391-09
NCGC00016391-10
NCGC00016391-13
NCGC00021665-03
NCGC00021665-04
NCGC00021665-05
NCGC00257845-01
S4601 5-Chloro-8-hydroxy-7-iodoquin
AS-14597
BC167259
HY-14603
SY051234
SBI-0206782.P001
DB-041956
AB00384254
NS00008116
4-stearylamino-phenyl-trimethylam. metilsulf.
EN300-20836
Clioquinol, VETRANAL(TM), analytical standard
component of Vioform-Hydrocortisone (Salt/Mix)
D03538
AB00384254_17
5-Chloro-7-iodo-8-quinolinol, >=95.0% (HPLC)
CU-01000000767-2
Q5134338
SR-01000002987-2
SR-01000002987-3
SR-01000002987-4
BRD-K09255212-001-04-2
BRD-K09255212-001-16-6
Z104483432
Clioquinol, British Pharmacopoeia (BP) Reference Standard
Clioquinol, European Pharmacopoeia (EP) Reference Standard
Clioquinol, United States Pharmacopeia (USP) Reference Standard
Clioquinol;5-Chloro-7-iodoquinolin-8-ol;5-Chloro-7-iodo-8-hydroxyquinoline
InChI=1/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13
5-Chloro-7-iodo-8-hydroxyquinoline; 5-Chloro-7-iodo-8-quinolinol; 5-Chloro-8-hydroxy-7-iodoquinoline; 5-Chloro-7-iodoquinolin-8-ol; Chloroiodeoquim; Iodochlorhydroxyquin
CQL