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Clozapine

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Identification
Molecular formula
C18H19ClN4
CAS number
5786-21-0
IUPAC name
5-chloro-9,10-dimethyl-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraene
State
State

At room temperature, clozapine is in the solid state, typically found in the form of a crystalline powder. This makes it suitable for formulation into tablets for oral administration.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.15
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.15
General information
Molecular weight
326.82g/mol
Molar mass
326.8240g/mol
Density
1.2820g/cm3
Appearence

Clozapine is a pale yellow crystalline powder. It can appear slightly off-white in its pure form, but the exact shade may vary based on purity and particle size.

Comment on solubility

Solubility of 5-chloro-9,10-dimethyl-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraene

The solubility characteristics of the compound 5-chloro-9,10-dimethyl-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraene provide insight into its behavior in various environments. Understanding solubility is crucial as it influences a compound's functionality and application. Here are some key points regarding its solubility:

  • Polarity: The presence of chlorine and nitrogen atoms may increase polar interactions, affecting solubility in polar solvents.
  • Solvent Interaction: This compound is more likely to dissolve in organic solvents, such as ethanol or acetone, rather than in water due to its complex structure.
  • Temperature Dependency: It's likely that solubility increases with temperature, aiding in dissolution in selected solvents.
  • Stability: The solubility might also depend on molecular stability, which can be affected by factors like light and heat exposure.

In the context of practical applications, understanding the solubility of such a complex molecule could lead to advancements in fields like pharmaceuticals, where solubility is directly linked to bioavailability. Thus, conducting experiments to determine exact solubility parameters in various solvents is vital.

Interesting facts

Interesting Facts about 5-chloro-9,10-dimethyl-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraene

This fascinating compound is part of a broad family of polycyclic compounds, known for their complex structures and diverse applications. Here are some key points that highlight its significance:

  • Structural Intricacy: The compound displays a unique arrangement of nitrogen and carbon atoms forming a tricyclic structure. This dimensional complexity is essential for understanding its chemical properties and reactivity.
  • Chloro Group Influence: The presence of a chlorine atom at the 5-position enhances the compound's reactivity, making it a target for various chemical transformations, including nucleophilic substitution reactions.
  • Applications in Research: Compounds with similar structures are often studied in the field of medicinal chemistry for their potential as pharmaceuticals. They can exhibit interesting biological activities, affecting various biological targets.
  • Photophysical Properties: These types of polycyclic compounds frequently exhibit interesting photophysical properties, meaning they can absorb and emit light, opening avenues for applications in optics and materials science.
  • Importance in Organic Synthesis: Understanding the reactivity and properties of this compound may lead to new methods of synthesis for more complex organic molecules, contributing to advancements in chemical synthesis.

In summary, 5-chloro-9,10-dimethyl-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraene is not just a chemical entity; it holds a place in the vast web of organic chemistry, where its unique characteristics dictate its behavior and potential utility in scientific research and development. As one might say in research circles, “The complexity of a compound can often reveal the beauty of nature’s design.”

Synonyms
BRN 4139554
DTXSID60959661
9-Chloro-5,6-dimethyl-3,4,5,6-tetrahydro-1H-azepino(5,4,3-cd)indole
1H-AZEPINO(5,4,3-cd)INDOLE, 3,4,5,6-TETRAHYDRO-9-CHLORO-5,6-DIMETHYL-
9-Chloro-5,6-dimethyl-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole
DTXCID701387535
5-23-07-00388 (beilstein handbook reference)
3889-07-4