Interesting facts
Interesting Facts about 5-Chloro-N-[2-[4-(Cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxy-benzamide
This compound is a member of the benzamide family, a class of compounds known for their diverse biological activities. As an advanced organic molecule, it incorporates a variety of functional groups that contribute to its unique properties and potential applications.
Key Features
- Anti-inflammatory Properties: Many compounds within the benzamide category, particularly those with sulfamoyl groups, exhibit significant anti-inflammatory effects, making them promising candidates for treating various inflammatory diseases.
- Complex Structure: This molecule’s structure includes a chlorobenzene moiety, a methoxy group, and a cyclohexylcarbamoyl moiety, which all enhance its biological activity and hydrophobic character.
- Cyclohexylcarbamoylsulfamoyl Group: The inclusion of this group is particularly interesting, as it can influence the binding affinity and selectivity towards biological targets, such as enzymes or receptors.
Moreover, research suggests that compounds like this can interfere with key biological pathways, potentially allowing for innovations in medicinal chemistry. The development of similar compounds has led to new therapeutics for diseases such as cancer and autoimmune disorders.
Quote from a Chemist
"The precise arrangement of atoms in complex molecules like this one holds the key to unlocking new therapeutic avenues. Each element plays a crucial role in its overall behavior." - A Chemistry Researcher
In summary, the intricate structure and potential biological applications of 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxy-benzamide make it a fascinating subject of study in the world of pharmaceutical research.
Synonyms
glyburide
Glibenclamide
10238-21-8
Glybenclamide
Glynase
Diabeta
Micronase
Euglucon
Daonil
Glybenzcyclamide
Semi-daonil
Apo-Glibenclamide
Azuglucon
Bastiverit
Benclamin
Betanase
Duraglucon
Euglucan
Euglykon
Glibenil
Glucolon
Orabetic
Prodiabet
Renabetic
Yuglucon
Dibelet
Gilemal
Glibens
Glibil
Glimel
Glimide
Humedia
Libanil
Maninil
Suraben
Tiabet
Adiab
Melix
Pira
Med-Glionil
Euglucon 5
Glibenclamida
Glibenclamidum
Calabren
Euclamin
Gewaglucon
Glibenbeta
Glibesyn
Glibetic
Gliboral
Glidiabet
Glisulin
Glitisol
Glucobene
Glucohexal
Glucomid
Glucoremed
Glucoven
Glycomin
Hexaglucon
Lederglib
Lisaglucon
Miglucan
Normoglucon
Praeciglucon
Cytagon
Debtan
Glamide
Gliban
Gliben
Glibet
Glicem
Gluben
Glyben
Sugril
Nadib
Novo-Glyburide
Glibenclamid AL
Gen-Glybe
Norglicem 5
Betanese 5
Glibenclamid Fabra
Glibenclamid Basics
Glibenclamid-Cophar
Glibenclamid Heumann
Semi-Euglucon
Hemi-Daonil
Glibenclamid Genericon
Glibenclamid-Ratiopharm
Semi-Gliben-Puren N
5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide
Glibenclamid Riker M.
HB 419
Glibenclamidum [INN-Latin]
Glyburide (micronized)
GBN 5
Glibenclamida [INN-Spanish]
Micronized glyburide
UR 606
glyburide (glibenclamide)
1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea
1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea
HB-419
Amglidia
Cirara
UNII-SX6K58TVWC
U 26452
SX6K58TVWC
5-Chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide
EINECS 233-570-6
MFCD00056625
NSC-759618
Neogluconin
BRN 2230085
CHEBI:5441
5-chloro-N-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-2-methoxybenzamide
Glibenclamide [INN]
5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
Glyburide [USAN:USP]
N-(4-(2-(5-Chloro-2-methoxybenzamido)ethyl)phenylsulfonyl)-N'-cyclohexylurea
Benzamide, 5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxy-
Glubate
CHEMBL472
U-26452
RP-1127
U-26,452
Urea, 1-(p-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexyl-
5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]-amino]sulfonyl]phenyl]-ethyl]-2-methoxybenzamide
MLS000069721
DTXSID0037237
5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide
U-26,45
Urea, 1-((p-(2-(chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl-
GLUCOVANCE COMPONENT GLYBURIDE
Benzamide, 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-
N-(4-(beta-(2-Methoxy-5-chlorbenzamido)-aethyl)-benzolsulfonyl)-N'-cyclohexyl-harnstoff
NSC 759618
Glyburide [USAN]
NCGC00015467-11
Abbenclamide
Diabiphage
Glibadone
SMR000058229
Glyburide (USAN:USP)
C23H28ClN3O5S
CAS-10238-21-8
N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N'-cyclohexylurea
GLYBURIDE (USP-RS)
GLYBURIDE [USP-RS]
Glibenclamidum (INN-Latin)
5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide
Glibenclamida (INN-Spanish)
GLIBENCLAMIDE (MART.)
GLIBENCLAMIDE [MART.]
DTXCID8017237
GLYBURIDE (USP MONOGRAPH)
GLYBURIDE [USP MONOGRAPH]
Glycron
GLIBENCLAMIDE (EP MONOGRAPH)
GLIBENCLAMIDE [EP MONOGRAPH]
1-[[p-[2-(5-Chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-cyclohexylurea
5-chloro-N-(2-{4-[N-(N-cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide
Glyburide (USP)
Micronase (TN)
1-{4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonyl}-3-cyclohexylurea;1-{4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonyl}-3-cyclohexylurea
Diabeta (TN)
Glynase (TN)
SR-01000000196
Delmide
5-chloro-N-(2-(4-(N-(N-cyclohexylcarbamoyl)sulfamoyl)phenyl)ethyl)-2-methoxybenzamide
5-chloro-N-(4-[N-(cyclohexylcarbamoyl)sulfamoyl]phenethyl)-2-methoxybenzamide
Glibenclamide,(S)
GBM
Glyburide;5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide
Prestwick_569
Spectrum_000250
Tocris-0911
Glybenzcyclamide, 99%
Glibenclamide; Glyburide
Opera_ID_801
GLYBURIDE [MI]
Glibenclamide (Standard)
Prestwick0_000316
Prestwick1_000316
Prestwick2_000316
Prestwick3_000316
Spectrum2_001816
Spectrum3_001327
Spectrum4_001199
Spectrum5_001631
GLYBURIDE [VANDF]
Lopac-G-0639
Probes1_000431
Probes2_000378
UPCMLD-DP006
G 0639
GLIBENCLAMIDE [JAN]
GLYBURIDE [WHO-IP]
Glibenclamide (JP18/INN)
CBiol_001790
Lopac0_000499
Oprea1_764617
SCHEMBL22009
BSPBio_000312
BSPBio_001351
BSPBio_003053
KBioGR_000071
KBioGR_001897
KBioSS_000071
KBioSS_000730
MLS001077262
BIDD:GT0239
DivK1c_000481
SPECTRUM2300229
SPBio_001831
SPBio_002531
GLIBENCLAMIDE [WHO-DD]
GLIBENCLAMIDE [WHO-IP]
BPBio1_000344
GTPL2414
GLYBURIDE [ORANGE BOOK]
UPCMLD-DP006:001
HMS501I03
KBio1_000481
KBio2_000071
KBio2_000730
KBio2_002639
KBio2_003298
KBio2_005207
KBio2_005866
KBio3_000141
KBio3_000142
KBio3_002273
A10BB01
Glibenclamide - Bio-X trade mark
Glybenclamide, >=99% (HPLC)
NINDS_000481
Bio1_000076
Bio1_000565
Bio1_001054
Bio2_000071
Bio2_000551
HMS1361D13
HMS1568P14
HMS1791D13
HMS1922L08
HMS1989D13
HMS2089L06
HMS2093P04
HMS2095P14
HMS3259O12
HMS3261D19
HMS3267A15
HMS3402D13
HMS3411F16
HMS3428D15
HMS3651E17
HMS3675F16
HMS3712P14
Pharmakon1600-02300229
BCP05327
PXB98502
Glibenclamide for peak identification
Tox21_110158
Tox21_300758
Tox21_500499
BDBM50012957
CCG-39618
HD 419
HY-15206R
NSC759618
NSC813214
STK362992
GLIBENCLAMIDUM [WHO-IP LATIN]
Glyburide - CAS 10238-21-8
AKOS001487495
Tox21_110158_1
BCP9000729
CS-1075
DB01016
FC23675
KS-5326
LP00499
NC00566
NSC-813214
SB17414
SDCCGSBI-0050483.P004
5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)-phenethyl)-2-methoxybenzamide
GLYBURIDE COMPONENT OF GLUCOVANCE
IDI1_000481
IDI1_033821
Glibenclamide 1.0 mg/ml in Acetonitrile
NCGC00015467-01
NCGC00015467-02
NCGC00015467-03
NCGC00015467-04
NCGC00015467-05
NCGC00015467-06
NCGC00015467-07
NCGC00015467-08
NCGC00015467-09
NCGC00015467-10
NCGC00015467-12
NCGC00015467-13
NCGC00015467-14
NCGC00015467-15
NCGC00015467-16
NCGC00015467-17
NCGC00015467-18
NCGC00015467-20
NCGC00015467-21
NCGC00015467-36
NCGC00015467-37
NCGC00016689-01
NCGC00023447-02
NCGC00023447-04
NCGC00023447-05
NCGC00023447-06
NCGC00023447-07
NCGC00023447-08
NCGC00023447-09
NCGC00023447-10
NCGC00023447-11
NCGC00023447-12
NCGC00254662-01
NCGC00261184-01
BG166164
HY-15206
SY057080
SBI-0050483.P003
Glyburide, meets USP testing specifications
AB00051949
EU-0100499
G0382
NS00001144
S1716
SW195828-5
C07022
D00336
D81733
EN300-117270
M01823
AB00051949-16
AB00051949-17
AB00051949_18
AB00051949_19
Q420626
SR-01000000196-2
SR-01000000196-4
SR-01000000196-5
SR-01000000196-6
SR-01000000196-8
BRD-K36927236-001-06-0
BRD-K36927236-001-17-7
BRD-K36927236-001-30-0
BRD-K36927236-001-31-8
BRD-K36927236-001-32-6
Z277540138
Glybenclamide, European Pharmacopoeia (EP) Reference Standard
Glyburide, United States Pharmacopeia (USP) Reference Standard
1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl urea
5-Chloro-N-[4-(3-cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide
4-(2-(5-Chloro-2-methoxybenzoylamino)ethyl)-N-(cyclohexylcarbamoyl)benzenesulfonamide
Glibenclamide for peak identification, European Pharmacopoeia (EP) Reference Standard
Glyburide (Glibenclamide), Pharmaceutical Secondary Standard; Certified Reference Material
N-(4-(.beta.-(2-Methoxy-5-chlorbenzamido)-aethyl)-benzolsulfonyl)-N'-cyclohexyl-harnstoff
N1-[4-({[(cyclohexylamino)carbonyl]amino}sulfonyl)phenethyl]-5-chloro-2-methoxybenzamide
233-570-6
5-Chloro-N-(2-[4-(([(cyclohexylamino)carbonyl]amino)sulfonyl)phenyl]ethyl)-2-methoxybenzamide #
Solubility of 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxy-benzamide
The compound 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxy-benzamide, with the chemical formula C17H14ClN3O2S, exhibits distinctive solubility characteristics attributed to its complex structure. Understanding its solubility is crucial for its applications in various domains of chemistry and pharmaceuticals. Here are several key points regarding its solubility:
As a general rule, compounds with increased polarity and the ability to interact through hydrogen bonds tend to dissolve better in polar solvents. However, due to the bulky cyclohexyl and phenyl groups, one might expect some degree of hydrophobicity, potentially reducing solubility in water. Thus, it is vital to consider the balance of hydrophilic and hydrophobic characteristics when evaluating solubility.
In summary, although the compound may exhibit moderate solubility in aqueous conditions due to its polar groups, the overall solubility profile will likely be influenced by the solvent nature and the environmental conditions (temperature, pH). Comprehensive solubility testing would provide a clearer picture of its behavior in various solvents.