Skip to main content

Carprofen

ADVERTISEMENT
Identification
Molecular formula
C15H12Cl2NO2
CAS number
53716-49-7
IUPAC name
5-chloro-N-(2,5-dichlorophenyl)-2-hydroxy-3-phenyl-benzamide
State
State

At room temperature, Carprofen remains in a solid state. It is typically stable and non-volatile, making it well-suited for pharmaceutical applications.

Melting point (Celsius)
211.00
Melting point (Kelvin)
484.15
Boiling point (Celsius)
540.00
Boiling point (Kelvin)
813.15
General information
Molecular weight
273.17g/mol
Molar mass
273.6880g/mol
Density
1.1976g/cm3
Appearence

Carprofen appears as a white crystalline solid. It is usually available in powder form or pressed into tablets for medicinal applications. It is not hygroscopic, maintaining its solid state when exposed to typical atmospheric conditions.

Comment on solubility

Solubility of 5-chloro-N-(2,5-dichlorophenyl)-2-hydroxy-3-phenyl-benzamide

The solubility characteristics of 5-chloro-N-(2,5-dichlorophenyl)-2-hydroxy-3-phenyl-benzamide are influenced by its complex molecular structure, which incorporates multiple aromatic rings and chlorinated substituents. Several key factors can affect its solubility:

  • Polarity: The presence of polar hydroxyl (-OH) functional groups can enhance solubility in polar solvents like water, but the significant hydrophobic aromatic portions may limit overall water solubility.
  • Chlorination: The chlorinated groups in the compound generally increase hydrophobicity, which may further reduce solubility in polar solvents.
  • Solvent Choice: This compound may exhibit increased solubility in organic solvents such as ethanol, acetone, or DMSO due to their non-polar to moderately polar nature.
  • Temperature: Solubility can be temperature-dependent, with higher temperatures often facilitating increased solubility in certain solvents.

In summary, while 5-chloro-N-(2,5-dichlorophenyl)-2-hydroxy-3-phenyl-benzamide is likely to have some degree of solubility in both polar and non-polar solvents, it may struggle to dissolve in water due to its overall molecular characteristics. Understanding these solubility dynamics is crucial for applications in formulation and drug development.

Interesting facts

Interesting Facts about 5-chloro-N-(2,5-dichlorophenyl)-2-hydroxy-3-phenyl-benzamide

5-chloro-N-(2,5-dichlorophenyl)-2-hydroxy-3-phenyl-benzamide, often referred to in research as a type of benzamide derivative, has several remarkable characteristics, particularly in the fields of medicinal chemistry and agrochemical research. Here are some fascinating insights:

  • Pharmaceutical Potential: This compound has shown promising activity against various biological targets, making it a candidate for further investigation in drug discovery processes.
  • Chlorine Atoms: The presence of multiple chlorine substituents plays a crucial role in enhancing the compound's lipophilicity, which can improve its bioavailability and effectiveness as a therapeutic agent.
  • Hydroxyl Group: The hydroxyl group attached to the aromatic ring enhances the compound's ability to form hydrogen bonds, which can be crucial for its interactions with biological targets.

This compound exemplifies the delicate balance between structure and function. The substituents on the benzamide core not only influence the compound's chemical reactivity but are also essential in determining its pharmacological properties.

Research Applications

Numerous studies have harnessed compounds like this one for various applications:

  • Antimicrobial action: Investigations are ongoing to explore its efficacy against various pathogens.
  • Cancer Research: It has been noted for potential antiproliferative effects in certain cancer cell lines.
  • Agricultural Use: Some benzamide derivatives similarly have been studied for their herbicidal properties.

In conclusion, 5-chloro-N-(2,5-dichlorophenyl)-2-hydroxy-3-phenyl-benzamide serves as a striking example of how chemical modifications can lead to novel compounds with significant biological activities. As research progresses, this compound may open new avenues for both therapeutic and agricultural applications.

Synonyms
Monsanto CP-42320
OM-1459
BRN 2773688
5607-54-5
ENT 27,135
(1,1'-BIPHENYL)-3-CARBOXAMIDE, 5-CHLORO-N-(2,5-DICHLOROPHENYL)-2-HYDROXY-
5-Chloro-N-(2,5-dichlorophenyl)-2-hydroxy-(1,1'-biphenyl)-3-carboxamide
DTXSID40204621
DTXCID70127112