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5-Chloro-N-(3-chlorophenyl)-2-hydroxybenzamide

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Identification
Molecular formula
C13H9Cl2NO2
CAS number
66915-74-4
IUPAC name
5-chloro-N-(3-chlorophenyl)-2-hydroxy-benzamide
State
State

Solid: This compound is a solid at room temperature, maintaining its structural integrity in the form of a crystalline powder.

Melting point (Celsius)
207.00
Melting point (Kelvin)
480.15
Boiling point (Celsius)
343.00
Boiling point (Kelvin)
616.15
General information
Molecular weight
280.12g/mol
Molar mass
280.1210g/mol
Density
1.4645g/cm3
Appearence

The compound typically appears as a white to off-white crystalline powder. This appearance is consistent with many aromatic amides.

Comment on solubility

Solubility of 5-chloro-N-(3-chlorophenyl)-2-hydroxy-benzamide

The solubility of 5-chloro-N-(3-chlorophenyl)-2-hydroxy-benzamide can be influenced by several factors due to its complex structure. This compound, characterized by its multiple aromatic rings and various substituents, exhibits varying solubility in different solvents. Here are some key points regarding its solubility:

  • Polar Solvents: The presence of a hydroxyl group (-OH) can enhance solubility in polar solvents like water and methanol. This group is capable of hydrogen bonding, which aids in solvation.
  • Non-Polar Solvents: Conversely, its aromatic nature may lead to higher solubility in non-polar organic solvents such as hexane or toluene, where the aromatic rings can engage in π-π interactions.
  • Temperature Dependency: Solubility is typically temperature dependent. Increased temperature may improve the solubility of the compound in both polar and non-polar solvents.
  • Effects of Substituents: The chloro substituents may also influence solubility. Generally, electron-withdrawing groups can alter the compound’s ability to interact with solvent molecules.

In conclusion, the solubility of 5-chloro-N-(3-chlorophenyl)-2-hydroxy-benzamide is a function of its functional groups and the nature of the solvent, making it an interesting topic for further study in solubility science.

Interesting facts

Interesting Facts about 5-Chloro-N-(3-chlorophenyl)-2-hydroxy-benzamide

5-Chloro-N-(3-chlorophenyl)-2-hydroxy-benzamide, often referred to in research circles as an intriguing compound, has garnered attention due to its unique structure and potential applications. Here are some captivating insights:

  • Pharmacological Potential: This compound belongs to the class of benzamides, which are frequently studied for their biological activities, including antimicrobial and anti-inflammatory properties.
  • Diverse Substitution: The presence of multiple chlorine atoms in its structure suggests a significant impact on the compound's reactivity and biological interactions. Chlorinated compounds are noted for their enhanced lipophilicity, which can affect absorption and distribution in biological systems.
  • Hydroxyl Group Influence: The –OH (hydroxyl) functional group contributes to the compound’s ability to engage in hydrogen bonding, impacting solubility and biological activity. It may also play a role in the compound's mechanism of action against certain targets.
  • Structure Activity Relationship (SAR): Scientists often conduct SAR studies on benzamide derivatives to optimize their pharmacological profiles, making this compound a key subject for further medicinal chemistry research.
  • Environmental Impact: Compounds containing chlorine can pose ecological risks; thus, understanding their persistence and degradation pathways in the environment is crucial for sustainability considerations.

In conclusion, 5-Chloro-N-(3-chlorophenyl)-2-hydroxy-benzamide holds promise in various fields of research, and its unique characteristics make it an exciting subject for ongoing studies in medicinal chemistry and environmental science. As with many chemical compounds, the balance between efficacy and safety will determine its future applications.

Synonyms
22203-98-1
3',5-DICHLOROSALICYLANILIDE
L9HQV0JFNH
UNII-L9HQV0JFNH
Benzamide, 5-chloro-N-(3-chlorophenyl)-2-hydroxy-
NSC-50643
DTXSID80176752
5,3'-DICHLOROSALICYLANILIDE
NSC 50643
SALICYLANILIDE, 3',5-DICHLORO-
DTXCID4099243
5-chloro-N-(3-chlorophenyl)-2-hydroxybenzamide
SARS-CoV-2-IN-14
Benzamide,5-chloro-N-(3-chlorophenyl)-2-hydroxy-
CHEMBL2088011
5-CHLORO-N-(3-CHLOROPHENYL)-2-HYDROXY-BENZAMIDE
NSC50643
SCHEMBL11932152
GFA02199
BDBM50540442
MFCD11521629
AKOS008973124
TS-09240
DB-213112
HY-144771
CS-0434458
Q27282873
Z68143799