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5-Chloro-2-hydroxy-N-(4-chlorophenyl)benzamide

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Identification
Molecular formula
C13H9Cl2NO2
CAS number
103-90-2
IUPAC name
5-chloro-N-(4-chlorophenyl)-2-hydroxy-benzamide
State
State

At room temperature, 5-chloro-2-hydroxy-N-(4-chlorophenyl)benzamide is in a solid state.

Melting point (Celsius)
269.00
Melting point (Kelvin)
542.15
Boiling point (Celsius)
357.00
Boiling point (Kelvin)
630.15
General information
Molecular weight
267.13g/mol
Molar mass
267.1270g/mol
Density
1.4500g/cm3
Appearence

5-Chloro-2-hydroxy-N-(4-chlorophenyl)benzamide typically appears as a crystalline solid. The compound is usually white or off-white in color.

Comment on solubility

Solubility of 5-chloro-N-(4-chlorophenyl)-2-hydroxy-benzamide

5-chloro-N-(4-chlorophenyl)-2-hydroxy-benzamide, a compound with the molecular formula C13H10Cl2N2O, exhibits variable solubility characteristics depending on the solvent used. Understanding its solubility profile is crucial for applications in pharmaceuticals and chemical synthesis. Here are some key points to consider:

  • Polar Solvents: The presence of hydroxyl (-OH) and amide (-C(=O)NH-) functional groups suggests that this compound may be more soluble in polar solvents such as water and alcohols.
  • Non-Polar Solvents: Conversely, the chlorophenyl groups and the overall hydrophobic character may limit solubility in non-polar solvents, such as hexane or benzene, making it less favorable in those environments.
  • Temperature Effects: Solubility can also change with temperature; generally, many organic compounds have increased solubility at elevated temperatures.

It is important to note that empirical solubility tests should be conducted in various solvents to accurately determine the solubility behavior of 5-chloro-N-(4-chlorophenyl)-2-hydroxy-benzamide. As a general guideline, one might find that:

  1. In water: moderate solubility is anticipated due to polar interactions.
  2. In alcohols: likely high solubility due to similar polar characteristics.
  3. In non-polar solvents: significantly low solubility expected.

In conclusion, the solubility of this compound is influenced by its structural features and the nature of the solvent, which is a crucial consideration for scientists working with this compound.

Interesting facts

Interesting Facts about 5-Chloro-N-(4-chlorophenyl)-2-hydroxy-benzamide

5-Chloro-N-(4-chlorophenyl)-2-hydroxy-benzamide is a fascinating compound that falls within the realm of aromatic compounds, known for their stability and unique reactivity. Here are some intriguing aspects about this particular compound:

  • Structural Significance: The presence of multiple chlorine atoms on the aromatic rings contributes to the compound's overall reactivity and chemical properties. Chlorine is an electronegative element, which can influence the electronic distribution in the molecule, making it a critical point of study in organic chemistry.
  • Pharmacological Potential: Compounds like 5-chloro-N-(4-chlorophenyl)-2-hydroxy-benzamide are explored for their potential as pharmaceuticals. The hydroxyl group (-OH) enhances the compound's ability to form hydrogen bonds, which can improve its efficacy in biological systems.
  • Applications in Research: This compound is often studied in the context of medicinal chemistry, particularly in the development of anti-cancer therapies and other therapeutic agents. Researchers investigate its interactions with biological targets to assess its potential effectiveness.
  • Environmental Impact: As a chlorine-containing compound, its environmental stability and potential for bioaccumulation are of great interest. Understanding how such compounds behave in biological systems and the environment is a key focus in the field of environmental chemistry.

In summary, 5-chloro-N-(4-chlorophenyl)-2-hydroxy-benzamide serves as a prime example of the interplay between structure and functionality in organic compounds. As chemists explore its characteristics and potential applications, it reinforces the important role that synthetic compounds play in advancing scientific knowledge and developing new technologies.

Synonyms
1147-98-4
5-chloro-N-(4-chlorophenyl)-2-hydroxybenzamide
Arylid
4',5-DICHLOROSALICYLANILIDE
Benzamide, 5-chloro-N-(4-chlorophenyl)-2-hydroxy-
5-CHLORO-N-(4-CHLOROPHENYL)-2-HYDROXY-BENZAMIDE
28D17I2DOG
CHEMBL2088012
7677-99-8
NSC 44167
BRN 2218448
UNII-28D17I2DOG
4-Chloroanilide of 5-chlorosalicylic acid
AI3-50101
Salicylanilide, 4',5-dichloro-
SCHEMBL2169619
DTXSID00862564
PVWWOFBIYKSBEX-UHFFFAOYSA-N
NSC44167
BDBM50540432
MFCD01684526
NSC-44167
AKOS008034892
DB-213113
NS00124529
EN300-7518820
Q27254302
Z68152307