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5-chloro-2-hydroxy-N-(3-(5-(trifluoromethyl)pyridin-2-yl)phenyl)benzamide

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Identification
Molecular formula
C19H11Cl3NO2
CAS number
6699-23-8
IUPAC name
5-chloro-N,3-bis(4-chlorophenyl)-2-hydroxy-benzamide
State
State

At room temperature, 5-chloro-N,3-bis(4-chlorophenyl)-2-hydroxy-benzamide is in a solid state. It is commonly encountered in powder or granulated form.

Melting point (Celsius)
261.00
Melting point (Kelvin)
534.20
Boiling point (Celsius)
570.20
Boiling point (Kelvin)
843.40
General information
Molecular weight
491.32g/mol
Molar mass
491.3170g/mol
Density
1.4370g/cm3
Appearence

This compound is typically found as a solid at room temperature. It may appear as a crystalline powder with a white to off-white color, although subtle variations can occur depending on specific conditions or impurities.

Comment on solubility

Solubility of 5-chloro-N,3-bis(4-chlorophenyl)-2-hydroxy-benzamide

The solubility of 5-chloro-N,3-bis(4-chlorophenyl)-2-hydroxy-benzamide can be quite complex due to its structural characteristics. Understanding the solubility of this compound is essential for various applications, including pharmaceutical formulations and environmental assessments. Several factors influence its solubility:

  • Polarity: The presence of hydroxyl (-OH) groups in the structure increases polarity, which may enhance solubility in polar solvents.
  • Chlorine Substituents: The numerous chlorine atoms in the structure can create steric hindrance and influence solubility in organic solvents, potentially making it less soluble in water.
  • Hydrogen Bonding: The ability to form hydrogen bonds with surrounding molecules plays a significant role; the -OH group could interact favorably with water molecules.

In general, it can be anticipated that 5-chloro-N,3-bis(4-chlorophenyl)-2-hydroxy-benzamide may exhibit limited solubility in water, while being more soluble in organic solvents such as dimethyl sulfoxide (DMSO) or ethanol. As with many compounds, assessing solubility is crucial for determining the best solvent system for experiments and applications.

Ultimately, understanding the solubility behavior of this compound requires careful consideration of these factors, as each can significantly alter interactions and dissolution properties.

Interesting facts

Interesting Facts about 5-chloro-N,3-bis(4-chlorophenyl)-2-hydroxy-benzamide

The compound 5-chloro-N,3-bis(4-chlorophenyl)-2-hydroxy-benzamide, often referred to in the realm of chemistry as a unique member of the amide class, possesses remarkable characteristics that make it a subject of interest for scientists and researchers alike.

Key Highlights:

  • Structural Complexity: This compound features a complex structure characterized by multiple aromatic rings and functional groups, which can significantly influence its chemical behavior.
  • Chlorine Substituents: The presence of chlorine atoms in the structure tends to enhance its biological activity, making compounds like this one vital in pharmaceutical research.
  • Hydroxy Group: The hydroxyl (-OH) group attached to the benzamide moiety not only contributes to the molecule's polarity but also plays a critical role in its reactivity and potential interaction with biological targets.
  • Research Relevance: Compounds similar to this one have been studied for their potential in medicinal chemistry, particularly in the development of anti-cancer agents and other therapeutics.

Additionally, the understanding of the electronic effects caused by the chlorine substituents can lead to the development of more efficient derivatives with enhanced properties. As chemists say, “substitution is the key to exploration,” which perfectly encapsulates the idea that modifying compounds can unlock new possibilities. This compound is an excellent example of how subtle changes can lead to substantial variations in activity and selectivity in biological systems.

In conclusion, the study of 5-chloro-N,3-bis(4-chlorophenyl)-2-hydroxy-benzamide exemplifies the intricate dance between structure and function in organic chemistry, paving the way for future innovations in drug discovery and material science.

Synonyms
Monsanto CP-43858
5-Chloro-3-(4-chlorophenyl)-4'-chlorosalicylanilide
ENT 27,139
4019-40-3
OM-1463
BRN 2773721
CP 43858
AI3-27139
Salicylanilide, 3-(4-chlorophenyl)-4',5-dichloro-
3-BIPHENYLCARBOXANILIDE, 4',4'',5-TRICHLORO-2-HYDROXY-
DTXSID80193186
(1,1'-Biphenyl)-3-carboxamide, 4',5-dichloro-N-(4-chlorophenyl)-2-hydroxy-
4',5-Dichloro-N-(4-chlorophenyl)-2-hydroxy-(1,1'-biphenyl)-3-carboxamide
5-chloro-3-(p-chlorophenyl)-4'-chlorosalicylanilide
DTXCID90115677
SCHEMBL7742767
5-chloro,3-(p-chlorophenyl) ,4'-chloro-sal icylanilide