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Nisoxetine

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Identification
Molecular formula
C19H24N2
CAS number
70144-24-2
IUPAC name
5-(diethylamino)-2-(1-naphthyl)pentanenitrile
State
State

At room temperature, Nisoxetine is in a solid state, appearing as a crystalline powder due to its organic nature.

Melting point (Celsius)
125.30
Melting point (Kelvin)
398.45
Boiling point (Celsius)
449.20
Boiling point (Kelvin)
722.35
General information
Molecular weight
272.39g/mol
Molar mass
272.3920g/mol
Density
1.0458g/cm3
Appearence

Nisoxetine, known in its pure form, is a white to off-white crystalline powder. It may appear as a solid at room temperature with a crystalline structure that is typical of organic compounds containing aromatic and nitrile groups.

Comment on solubility

Solubility of 5-(diethylamino)-2-(1-naphthyl)pentanenitrile

The solubility of 5-(diethylamino)-2-(1-naphthyl)pentanenitrile in various solvents can largely depend on its molecular structure and the presence of polar and non-polar characteristics. Typically, the compound exhibits:

  • Limited solubility in water: Due to its larger aromatic naphthyl group and long hydrocarbon chain, its affinity for water is reduced, making it less soluble.
  • Better solubility in organic solvents: It tends to dissolve quite well in organic solvents like ethanol, methanol, and dichloromethane.
  • Dependence on temperature: As with many organic compounds, increased temperature may enhance solubility in organic solvents.

As a general trend in pharmaceuticals and organic chemistry, compounds with significant non-polar regions often show a pattern of low aqueous solubility but high solubility in non-polar and slightly polar organic solvents. Consider this relationship as you explore solubility dynamics:

“Solubility is the key to understanding chemical interactions and reactivity.”

In summary, while 5-(diethylamino)-2-(1-naphthyl)pentanenitrile presents challenges in aqueous solutions, its solubility profile in organic solvents can be advantageous for various applications in synthesis and formulation.

Interesting facts

Exploring 5-(diethylamino)-2-(1-naphthyl)pentanenitrile

5-(diethylamino)-2-(1-naphthyl)pentanenitrile is a fascinating compound that blends both organic chemistry and pharmacology, showcasing the intriguing applications of nitriles in medicinal contexts. Here are some interesting facts about this compound:

  • Structural Diversity: This compound features a unique structure characterized by the presence of a diethylamino group, which enhances its solubility and biological activity. The 1-naphthyl moiety adds aromatic stability and contributes to the compound's overall properties.
  • Pharmacological Potential: Compounds like 5-(diethylamino)-2-(1-naphthyl)pentanenitrile are often studied for their potential as drug candidates. The nitrile functional group can play a critical role in the compound's ability to interact with biological targets.
  • Research Interest: Researchers are particularly interested in similar compounds for their ability to serve as intermediates in the synthesis of more complex pharmaceuticals. Their diverse chemical reactivity makes them valuable in drug development.
  • Application in Synthetic Chemistry: The presence of both amine and nitrile groups in this compound allows for the potential to create a variety of derivatives. This capability is particularly important in synthetic organic chemistry for designing customized compounds with specific functionalities.
  • Historical Context: Nitriles have been used historically in organic synthesis and have paved the way for the development of numerous biologically active compounds. Understanding the chemistry of compounds like this can lead to advancements in medicinal chemistry.

In summary, 5-(diethylamino)-2-(1-naphthyl)pentanenitrile exemplifies the intersection of organic synthesis and pharmacological potential. Its multifaceted properties present opportunities for extensive research and development in therapeutic applications, marking its significance in the field of chemistry.

Synonyms
6779-88-0
BRN 2743449
alpha-(3-(Diethylamino)propyl)-1-naphthaleneacetonitrile
1-NAPHTHALENEACETONITRILE, alpha-(3-(DIETHYLAMINO)PROPYL)-
DTXSID60987126
5-(diethylamino)-2-(naphthalen-1-yl)pentanenitrile