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Propafenone

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Identification
Molecular formula
C21H27NO
CAS number
54063-53-5
IUPAC name
5-(diethylamino)-2-[3-(diethylamino)propyl]-2-(1-naphthyl)pentanenitrile
State
State

At room temperature, propafenone is usually found in a solid state as a hydrochloride salt, which is used in medicinal formulations.

Melting point (Celsius)
141.00
Melting point (Kelvin)
414.15
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.15
General information
Molecular weight
341.49g/mol
Molar mass
341.4870g/mol
Density
1.1170g/cm3
Appearence

Propafenone appears as a white to off-white crystalline solid. It is typically odorless and is used in its hydrochloride salt form for pharmaceutical purposes, where it appears as a white, crystalline powder.

Comment on solubility

Solubility Overview

The compound 5-(diethylamino)-2-[3-(diethylamino)propyl]-2-(1-naphthyl)pentanenitrile, with its complex structure, presents unique solubility characteristics that are worth exploring.

Factors Influencing Solubility

Several key factors impact the solubility of this compound:

  • Polarity: The presence of both polar and non-polar functional groups influences its interaction with solvents.
  • Hydrogen Bonding: The diethylamino groups can engage in hydrogen bonding, enhancing solubility in polar solvents such as water.
  • Hydrophobic Interactions: The naphthyl portion is hydrophobic, which may hinder solubility in polar solvents while favoring solubility in organic solvents.

Solubility Characteristics

Based on common trends for compounds of this nature, one could anticipate:

  • The compound may exhibit limited solubility in water due to its hydrophobic naphthyl component.
  • It is likely to be more soluble in organic solvents such as ethanol or chloroform.
  • Its solubility may vary significantly with temperature and solvent polarity.

Conclusion

In summary, understanding the solubility of 5-(diethylamino)-2-[3-(diethylamino)propyl]-2-(1-naphthyl)pentanenitrile is crucial for its application in various chemical contexts. The interplay of its hydrophilic and hydrophobic features creates important considerations for its use in synthesis and formulation.

Interesting facts

Interesting Facts about 5-(diethylamino)-2-[3-(diethylamino)propyl]-2-(1-naphthyl)pentanenitrile

This compound is a fascinating member of the chemical world, known for its intricate structure and potential applications. It belongs to a class of compounds that have garnered interest in various scientific fields, particularly in medicinal chemistry and material sciences.

Chemical Structure and Properties

The unique structure of 5-(diethylamino)-2-[3-(diethylamino)propyl]-2-(1-naphthyl)pentanenitrile is characterized by:

  • Multiple Functional Groups: The presence of diethylamino groups makes this compound a possible candidate for neuroactive substances.
  • Naphthalene Ring: The incorporation of a naphthyl group enhances its hydrophobic character, which can influence its pharmacokinetic properties.
  • Cyanide Group: The nitrile (-C≡N) functional group adds to the reactivity of the compound, opening avenues for further chemical modifications.

Applications

Due to its unique properties, this compound may find potential uses in:

  • Drug Development: Its structure suggests potential utility in designing new pharmaceuticals, especially in the context of treating neurological disorders.
  • Research: It serves as an important tool in studying receptor interactions due to its ability to engage with various biological targets.
  • Material Science: Certain derivatives of similar compounds have been explored for applications in advanced materials, including organic semiconductors.

Scientific Insights

In the realm of scientific study, connections can be drawn between this compound and its analogs:

  • Neurotransmitter Analogues: Compounds with similar structures often mimic neurotransmitters, affecting their interactions with receptors.
  • Structure-Activity Relationships: Understanding how small changes in the molecular structure can lead to significant variations in biological activity is critical for drug design.

In conclusion, the compound 5-(diethylamino)-2-[3-(diethylamino)propyl]-2-(1-naphthyl)pentanenitrile represents a captivating blend of complexity and opportunity. Its unique characteristics and potential applications make it a subject of interest for researchers and students alike, inviting future exploration and innovations in chemistry.

Synonyms
13326-32-4
BRN 2777878
1-NAPHTHALENEACETONITRILE, alpha,alpha-BIS(3-(DIETHYLAMINO)PROPYL)-
alpha,alpha-Bis(3-(diethylamino)propyl)-1-naphthaleneacetonitrile
DTXSID60158031
alpha,alpha-Bis[3-(diethylamino)propyl]-1-naphthaleneacetonitrile
DTXCID1080522
5-(diethylamino)-2-[3-(diethylamino)propyl]-2-naphthalen-1-ylpentanenitrile