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Naproxen

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Identification
Molecular formula
C14H14O3
CAS number
22204-53-1
IUPAC name
5-(dimethylamino)-2-[3-(dimethylamino)propyl]-2-(1-naphthyl)pentanoic acid
State
State

At room temperature, Naproxen is typically a solid. It is available in various formulations for pharmaceutical applications, including tablets and suspensions.

Melting point (Celsius)
153.00
Melting point (Kelvin)
426.15
Boiling point (Celsius)
477.53
Boiling point (Kelvin)
750.68
General information
Molecular weight
230.27g/mol
Molar mass
230.2680g/mol
Density
1.1440g/cm3
Appearence

Naproxen is a white to off-white crystalline substance. It is slightly soluble in water and freely soluble in ethanol and methanol. The compound often appears as a white powder or crystalline solid.

Comment on solubility

Solubility of 5-(dimethylamino)-2-[3-(dimethylamino)propyl]-2-(1-naphthyl)pentanoic acid

The solubility of 5-(dimethylamino)-2-[3-(dimethylamino)propyl]-2-(1-naphthyl)pentanoic acid can be quite intriguing, as it showcases the complex interplay of its chemical structure and the solvent medium. Here are some key points to note:

  • Polarity: The presence of multiple amine groups enhances polarity, potentially increasing solubility in polar solvents such as water.
  • Hydrophobic Character: The naphthyl group adds a non-polar character that may hinder solubility in aqueous environments. This can lead to limited solubility in water but increased solubility in organic solvents.
  • pH Sensitivity: Being a carboxylic acid, its solubility can be significantly affected by pH. In acidic solutions, the acid remains protonated and may show lower solubility, whereas at higher pH, it can deprotonate, leading to enhanced solubility.

In conclusion, the solubility of this compound can be best described as contextual. Depending on the solvent nature and environmental conditions such as pH, the solubility can vary widely. Therefore, understanding these factors is essential for practical applications in various fields.

Interesting facts

Interesting Facts about 5-(dimethylamino)-2-[3-(dimethylamino)propyl]-2-(1-naphthyl)pentanoic acid

This compound is a fascinating member of the amine and carboxylic acid families, showcasing the complex interplay of functional groups in organic chemistry. Here are several intriguing aspects of this compound:

  • Biological Activity: The structure suggests potential biological activity, making it of interest in pharmaceutical research. Compounds with amine groups are often key players in drug development due to their ability to interact with biological targets.
  • Structure-Activity Relationship (SAR): The presence of multiple dimethylamino groups enhances the basicity of the molecule, potentially influencing its interaction with biological receptors and systems. Understanding its SAR can lead to insights in medicinal chemistry.
  • Applications in Research: This compound could be used as a *probe* in drug discovery research, helping scientists identify new therapeutic pathways or molecular mechanisms of action.
  • Complex Synthesis: The method of synthesizing such a complex molecule often involves multiple reaction steps, showcasing the intricate and diversified techniques utilized in organic synthesis, including condensation reactions and functional group transformations.
  • Environmental Considerations: As with many organic compounds, understanding the environmental impact and degradation pathways of this compound is critical, particularly if it finds applications in industry or pharmaceuticals.

In summary, 5-(dimethylamino)-2-[3-(dimethylamino)propyl]-2-(1-naphthyl)pentanoic acid is not just a simple compound but rather a potential cornerstone for further explorations in pharmaceutical sciences. Its unique structure enhances its importance, opening avenues for research and application.