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Olanzapine

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Identification
Molecular formula
C17H20N4O2
CAS number
132539-06-1
IUPAC name
5-(dimethylamino)-9-methyl-2-propyl-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3-dione
State
State

At room temperature, Olanzapine is in a solid state.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
312.38g/mol
Molar mass
312.4390g/mol
Density
1.2600g/cm3
Appearence

The compound is a pale yellow crystalline solid with a faint ammonia-like odor.

Comment on solubility

Solubility of 5-(dimethylamino)-9-methyl-2-propyl-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3-dione

The solubility of 5-(dimethylamino)-9-methyl-2-propyl-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3-dione can be described with several key points:

  • Solvent Dependence: This compound shows varying solubility depending on the solvent system used. It is primarily soluble in organic solvents.
  • Hydrophilicity vs. Hydrophobicity: The presence of dimethylamino groups suggests some polar characteristics, enabling interaction with polar solvents to a certain extent, though overall hydrophobic interactions dominate.
  • Temperature Effects: Generally, increased temperature may enhance the solubility of this compound in organic solvents.
  • pH Influence: The solubility might be affected by the pH of the medium, as protonation states could alter the compound’s interaction with solvents.

In conclusion, while 5-(dimethylamino)-9-methyl-2-propyl-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3-dione demonstrates versatility in solubility, it is essential to consider specific solvent characteristics and experimental conditions to achieve optimal dissolution.

Interesting facts

Interesting Facts About 5-(dimethylamino)-9-methyl-2-propyl-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3-dione

This compound, commonly referred to as a type of benzotriazine derivative, holds a unique position in the realm of chemistry due to its diverse applications and fascinating structural features. Here are some engaging points to consider:

  • Biological Activity: Compounds of this class are often studied for their potential biological activities, including anticancer properties, which makes them significant in pharmaceutical research.
  • Synthetic Versatility: The synthesis of this compound involves multiple steps that demonstrate the versatility and complexity of organic synthesis techniques. Chemists utilize various methods, including nucleophilic substitutions and cyclization reactions.
  • Structure-Activity Relationship: Understanding how modifications to the structure, like the addition of dimethylamino groups, affect the compound's pharmacological properties is a key area of research. This relationship is crucial for the design of more effective drug candidates.
  • Role of Pyrazole: The pyrazole ring present in its structure contributes to its biological properties, making it a subject of interest in medicinal chemistry. The reactivity and stability imparted by this ring are essential for its interactions with biological targets.
  • Research Applications: Such derivatives are regularly explored in studies aiming to discover new therapeutic agents or to enhance existing drugs. The ongoing research in the field illustrates the importance of optimizing chemical properties for better efficacy.

As noted by many researchers in the field, "The uniqueness of a compound's structure often leads to groundbreaking discoveries in both synthetic and medicinal chemistry." This underscores the significance of studying compounds like 5-(dimethylamino)-9-methyl-2-propyl-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3-dione.

As research continues to unfold, we can expect exciting developments from this compound, highlighting the endless possibilities chemical science offers for enhancing human health and understanding complex biological mechanisms.

Synonyms
Azapropazone
APAZONE
Cinnopropazone
13539-59-8
Azapropazona
Azapropazonum
Azapropazon
AHR-3018
NSC-102824
Mi-85
5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione
K2VOT966ZI
3-Dimethylamino-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine
DTXSID6045408
CHEBI:38010
1,2-Dihydro-3-dimethylamino-7-methyl-1,2-(propylmalonyl)-1,2,4-benzotriazine
1H-Pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-
NSC102824
MI-85DI
5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione
DTXCID6023735
1H-Pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-
Dihydrate, Apazone
Rheumox 600
M01AX04
236-913-8
Prolixan
Cinnamin
Rheumox
Sinnamin
Prolix
Xani
Azapropazone (anhydrous)
Apazone [USAN]
Prolixan 300
MI 85
AHR 3018
Azapropazon [German]
NSC 102824
Azapropazone [INN]
MLS002703748
Apazone (USAN)
Azapropazone (INN)
Azapropazon (German)
5-(dimethylamino)-9-methyl-2-propyl-1H-benzo[e]pyrazolo[1,2-a][1,2,4]triazine-1,3(2H)-dione
5-(dimethylamino)-9-methyl-2-propylpyrazolo[1,2-a][1,2,4]benzotriazine-1,3-dione
AHR-3018;NSC-102824;NSC102824;
Azapropazonum [INN-Latin]
Azapropazona [INN-Spanish]
SMR001233401
EINECS 236-913-8
UNII-K2VOT966ZI
BRN 0623763
NCGC00016701-01
Prolixan (TN)
CAS-13539-59-8
Tolyprin (Salt/Mix)
APAZONE [MI]
Prestwick0_001003
Prestwick1_001003
Prestwick2_001003
Prestwick3_001003
SCHEMBL3190
NCIOpen2_007171
AZAPROPAZONE [MART.]
BSPBio_001125
MLS002154093
(+/-)-APAZONE
Apazone dihydrate (Salt/Mix)
AZAPROPAZONE [WHO-DD]
SPBio_003006
BPBio1_001239
orb1701133
APAZONE, (+/-)-
CHEMBL1565476
SCHEMBL29399203
HMS1571I07
HMS2098I07
HMS2231L14
HMS3372M10
HMS3715I07
NAA53959
Tox21_110569
AKOS015914210
CCG-221003
NCGC00179297-01
NCGC00179297-04
DA-61364
1,2-(propylmalonyl)-1,2,4-benzotriazine
HY-116442
AB00513995
CS-0065495
NS00009426
D02966
Q368222
SR-01000838825
SR-01000838825-2
BRD-A70182876-001-10-8
WLN: T B566 BNV EVN HN DHJ D3 GN1&1 L1
3-Dimethylamino-7-methyl-1,2-dihydro-1,2,4-benzotriazine
3-Dimethylamino-7-methyl-1-2-(N-propylmalonyl)-1,2,4-benzotriazine
1,2-Dihydro-3-(dimethylamino)-7-methyl-1,2-(propylmalonyl)-1,2,4-benzotriazine
1H-Pyrazolo[1,2,4]benzotriazine-1,3(2H)-dione, 5-(dimethylamine)-9-methyl-2-propyl-
1H-Pyrazolo[1,2,4]benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-
5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo[1,2,4]benzotriazine-1,3(2H)-dione
5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo[1,2,4]benzotriazine-1,3(2H)dione
5-(dimethylamino)-9-methyl-2-propyl-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3-dione
1H-Pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione, 5-(dimethylamine)-9-methyl-2-propyl-
5-DIMETHYLAMINO-9-METHYL-2-PROPYLPYRAZOLO(1,2-A)(1,2,4)BENZOTRIAZINE-1,3(2H)-DIONE