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Pentobarbital

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Identification
Molecular formula
C11H18N2O3
CAS number
76-74-4
IUPAC name
5-ethyl-1-methyl-5-(1-methylbutyl)-2-(propylamino)pyrimidine-4,6-dione
State
State
Pentobarbital is in a solid state at room temperature. It is often found in crystalline form when not dissolved in a solution or mixed into a pharmaceutical preparation.
Melting point (Celsius)
129.00
Melting point (Kelvin)
402.15
Boiling point (Celsius)
219.50
Boiling point (Kelvin)
492.65
General information
Molecular weight
226.28g/mol
Molar mass
226.2770g/mol
Density
1.0800g/cm3
Appearence

Pentobarbital generally appears as a white crystalline solid. It is typically odorless and has a bitter taste. The compound is known for being quite soluble in alcohol and somewhat soluble in water, forming clear solutions. As a barbiturate, its solid form is commonly encountered in pharmaceutical formulations or scientific research settings.

Comment on solubility

Solubility Insights

The solubility of the compound 5-ethyl-1-methyl-5-(1-methylbutyl)-2-(propylamino)pyrimidine-4,6-dione can be influenced by various factors, including its molecular structure and the presence of functional groups. Here are some key points to consider:

  • Polarity: The molecule's functional groups can significantly affect polarity, and thus, solubility in different solvents. For example, the presence of amino groups can enhance solubility in polar solvents.
  • Hydrogen Bonding: This compound is likely capable of forming hydrogen bonds due to the presence of the amino group. This characteristic can improve solubility in polar solvents such as water.
  • Hydrophobic Regions: The bulky alkyl groups (ethyl and 1-methylbutyl) introduce hydrophobic portions that may reduce solubility in highly polar solvents but may enhance solubility in nonpolar or less polar organic solvents.
  • pH Dependency: Depending on the pH of the solution, the ionization state of the amino group can alter solubility. Increased ionization at higher pH levels can lead to better solubility in aqueous environments.

In summary, while specific solubility data for this compound may vary, understanding these structural influences provides insights into its potential solubility characteristics:

  • If dissolved in water, expect variations based on pH and the extent of hydrogen bonding.
  • In organic solvents, the solubility can be better due to hydrophobic interactions.

Ultimately, it is essential to analyze the compound experimentally to determine its precise solubility profile in various environments.

Interesting facts

Interesting Facts about 5-ethyl-1-methyl-5-(1-methylbutyl)-2-(propylamino)pyrimidine-4,6-dione

The compound 5-ethyl-1-methyl-5-(1-methylbutyl)-2-(propylamino)pyrimidine-4,6-dione belongs to the class of pyrimidines, which are known for their diverse biological activities. This specific compound has garnered attention in the fields of medicinal chemistry and pharmacology due to its potential therapeutic applications. Here are some fascinating aspects of this compound:

  • Structural Diversity: The presence of several alkyl groups and a propylamino moiety contributes to its structural complexity, which may influence its biological interactions and pharmacokinetics.
  • Biological Significance: Pyrimidines are integral to important biological processes. Compounds within this class are often studied for their roles as antimetabolites, which can inhibit critical cellular functions.
  • Therapeutic Potential: Research suggests that derivatives of pyrimidines have applications in treating various diseases, including cancer and infectious diseases.
  • Synthesis Challenges: Due to its complex structure, synthesizing this compound can pose significant challenges requiring advanced synthetic methodologies and multistep processes.

As a chemistry enthusiast, one might appreciate the balance of practicality and complexity exhibited by compounds like this. The dynamic nature of such molecules demonstrates how slight modifications in their structure can lead to dramatically different properties and applications.

In conclusion, 5-ethyl-1-methyl-5-(1-methylbutyl)-2-(propylamino)pyrimidine-4,6-dione serves as an exciting example of how structural characteristics can have profound implications in the realms of science and pharmacology. The ongoing research into such compounds underscores the endless possibilities in the field of medicinal chemistry.