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Phenytoin

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Identification
Molecular formula
C15H12N2O2
CAS number
57-41-0
IUPAC name
5-ethyl-1-methyl-5-phenyl-hexahydropyrimidine-2,4,6-trione
State
State

Phenytoin is typically solid at room temperature and is often encountered in the form of capsules or tablets.

Melting point (Celsius)
295.00
Melting point (Kelvin)
568.20
Boiling point (Celsius)
282.60
Boiling point (Kelvin)
555.80
General information
Molecular weight
252.27g/mol
Molar mass
252.2680g/mol
Density
1.1910g/cm3
Appearence

The compound is a white crystalline solid that is practically odorless.

Comment on solubility

Solubility of 5-ethyl-1-methyl-5-phenyl-hexahydropyrimidine-2,4,6-trione

The solubility of 5-ethyl-1-methyl-5-phenyl-hexahydropyrimidine-2,4,6-trione can be characterized as follows:

  • Polar vs Nonpolar: The presence of multiple functional groups within its structure increases its chances of solvation in polar solvents.
  • Solvent Compatibility: It is generally more soluble in polar organic solvents, such as methanol and ethanol, compared to nonpolar solvents like hexane.
  • Temperature Dependency: Solubility may increase with temperature, as is common with many organic compounds. This phenomenon can enhance dissolution rates in polar solvents.

In conclusion, while the exact solubility parameters can vary based on factors such as purity and environmental conditions, 5-ethyl-1-methyl-5-phenyl-hexahydropyrimidine-2,4,6-trione is likely to exhibit reasonable solubility in polar solvents, making it versatile for various applications.

Interesting facts

Interesting Facts about 5-ethyl-1-methyl-5-phenyl-hexahydropyrimidine-2,4,6-trione

The compound 5-ethyl-1-methyl-5-phenyl-hexahydropyrimidine-2,4,6-trione is a remarkable heterocyclic compound that presents a wealth of intriguing features:

  • Diverse Applications: This compound is noted for its versatility in various fields, particularly in medicinal chemistry. Its structural characteristics make it a valuable candidate for drug development, potentially aiding in the synthesis of pharmaceuticals.
  • Heterocyclic Importance: Being a heterocycle, it contains nitrogen atoms which may enhance its biological activity and reactivity. Compounds with such properties often display interesting mechanisms of action in biochemical processes.
  • Synthesis Opportunities: The chemical structure allows for numerous synthetic pathways, providing opportunities for chemists to design derivatives with enhanced efficacy or selectivity in therapeutic action.
  • Potential Research Interest: Due to its unique structural features, researchers are exploring its potential role as a lead compound in developing treatments for various diseases, including cancer and neurological disorders.
  • Structure-Activity Relationship (SAR): In medicinal chemistry, understanding the relation between the compound's structure and its biological activity is vital. Compounds like this one provide a platform to explore how slight modifications can lead to significant changes in efficacy.

As a compound rich in structural and functional intrigue, 5-ethyl-1-methyl-5-phenyl-hexahydropyrimidine-2,4,6-trione exemplifies the depth and potential of organic chemistry in advancing scientific knowledge and applications. Its diverse applications reaffirm the notion that even complex organic compounds can lead to groundbreaking discoveries!

Synonyms
Mephobarbital
METHYLPHENOBARBITAL
Mephobarbitone
Methylphenobarbitone
Metylfenemal
Enphenemal
Mebaral
Prominal
N-Methylphenobarbital
115-38-8
Menta-Bal
Enfenemal
Mephytal
Morbusan
Phemetone
Phemiton
Phemitone
Metyna
Methyl-calminal
1-Methylphenobarbital
N-Methylphenolbarbitol
Methylphenolbarbital
Methylphenobarbitonum
Metilfenobarbital
Methylphenylbarbituric acid
Isonal (roussel)
Methylphenobarbitalum
Metilfenobarbitale [DCIT]
5-Ethyl-1-methyl-5-phenylbarbituric acid
N-Ethylmethylphenylbarbituric acid
N-Methylethylphenylbarbituric acid
Methyl phenobarbitone
Metilfenobarbital [INN-Spanish]
Methylphenobarbitalum [INN-Latin]
1-Methyl-5-ethyl-5-phenylbarbituric acid
N-Methyl-5-phenyl-5-ethylbarbital
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-1-methyl-5-phenyl-
5-ethyl-1-methyl-5-phenyl-1,3-diazinane-2,4,6-trione
5-Ethyl-N-methyl-5-phenylbarbituric acid
1-Methyl-5-phenyl-5-ethylbarbituric acid
5-Phenyl-5-ethyl-3-methylbarbituric acid
Mephobarbital civ
5-Ethyl-5-phenyl-N-methyl-bartituric acid
5-Ethyl-1-methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione
Barbituric acid, 5-ethyl-1-methyl-5-phenyl-
Enphenemalum
Methylphenobarbital (INN)
Methylphenobarbital [INN]
5-ethyl-1-methyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione
5NC67NU76B
CHEBI:6758
Prominaletten
Prominalum
DTXSID4023258
NCGC00159357-02
Meberal
Mephobarbital [JAN]
Metilfenobarbitale
5-Ethyl-1-methyl-5-phenyl-pyrimidine-2,4,6-trione
Mebaral (TN)
HSDB 3579
Methylphenobarbital (1.0mg/ml in Acetonitrile)
EINECS 204-085-7
Mephobarbital (JAN/USP)
Mephobarbital [USP:JAN]
BRN 0256144
UNII-5NC67NU76B
DEA No. 2250
N-Methyl-5-phenyl-5-ethylbarbituric acid
Phenobarbital, mono-methyl
MEPHOBARBITAL [MI]
(.+/-.)-Mephobarbital
Cambridge id 5240602
MEPHOBARBITAL [HSDB]
Oprea1_133475
SCHEMBL35624
MEPHOBARBITAL [VANDF]
5-24-09-00294 (Beilstein Handbook Reference)
CHEMBL45029
DTXCID403258
ALARQZQTBTVLJV-UHFFFAOYSA-
MEPHOBARBITAL CIV [USP-RS]
METHYLPHENOBARBITAL [MART.]
METHYLPHENOBARBITAL [WHO-DD]
Tox21_111600
MEPHOBARBITAL [USP MONOGRAPH]
STK732046
AKOS002254670
DB00849
NCGC00159357-03
CAS-115-38-8
METHYLPHENOBARBITAL [EP MONOGRAPH]
Methylphenobarbital 0.1 mg/ml in Methanol
Methylphenobarbital 1.0 mg/ml in Methanol
NS00008035
C07829
D00700
A803425
Q411697
1-Methyl-5-ethyl-5-phenyl-pyrimidine-2,4,6-trione
Hexahydropyrimidine-2,4,6-trione,1-methyl-5-ethyl-5-phenyl-
Mephobarbital, United States Pharmacopeia (USP) Reference Standard
Methylphenobarbital, European Pharmacopoeia (EP) Reference Standard
pyrimidine-2,4,6(1H,3H,5H)-trione, 5-ethyl-1-methyl-5-phenyl-
Methylphenobarbital, 1.0 mg/mL in methanol, certified reference material
InChI=1/C13H14N2O3/c1-3-13(9-7-5-4-6-8-9)10(16)14-12(18)15(2)11(13)17/h4-8H,3H2,1-2H3,(H,14,16,18)