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Barbital

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Identification
Molecular formula
C12H16N2O3
CAS number
57-44-3
IUPAC name
5-ethyl-5-(2-hydroxy-2-phenyl-ethyl)hexahydropyrimidine-2,4,6-trione
State
State

At room temperature, barbital exists in a solid state, typically as a crystalline powder.

Melting point (Celsius)
191.00
Melting point (Kelvin)
464.15
Boiling point (Celsius)
405.00
Boiling point (Kelvin)
678.15
General information
Molecular weight
238.27g/mol
Molar mass
238.2730g/mol
Density
1.1661g/cm3
Appearence

Barbital typically appears as a white crystalline powder or as colorless crystals, depending on its preparation. It is odorless and has a slightly bitter taste.

Comment on solubility

Solubility Characteristics of 5-ethyl-5-(2-hydroxy-2-phenyl-ethyl)hexahydropyrimidine-2,4,6-trione

The solubility of 5-ethyl-5-(2-hydroxy-2-phenyl-ethyl)hexahydropyrimidine-2,4,6-trione can be influenced by various factors due to its complex structure. Understanding its solubility behavior is crucial for applications in pharmaceuticals and organic synthesis. Here are some key points regarding its solubility:

  • Solvent Choice: This compound may exhibit different solubility rates in polar vs. non-polar solvents. Generally, compounds with hydroxyl groups tend to be more soluble in polar solvents like water.
  • Hydrophilicity: The presence of the hydroxyl group suggests potential hydrophilicity, which could enhance solubility in aqueous environments.
  • Temperature Effects: Increasing temperature may enhance the dissolution process, as is common with many organic compounds.
  • Concentration Factors: The solubility might also vary with concentration levels, requiring attention to saturation limits when preparing solutions.
  • pH Sensitivity: Due to the potential for ionization of the hydroxyl group, the compound’s solubility can be affected by the pH of the environment.

In summary, while specific quantitative solubility data for this compound can be variable, it is clear that factors such as solvent selection, temperature, and the presence of functional groups are significant contributors to its solubility characteristics. Further experimentation is often required to elucidate exact solubility values for practical applications.

Interesting facts

Interesting Facts about 5-ethyl-5-(2-hydroxy-2-phenyl-ethyl)hexahydropyrimidine-2,4,6-trione

5-ethyl-5-(2-hydroxy-2-phenyl-ethyl)hexahydropyrimidine-2,4,6-trione, often addressed in the realm of organic chemistry, showcases a fascinating blend of structural complexity and functional potential. Here are some intriguing insights about this compound:

  • Unique Structure: This compound features a hexahydropyrimidine core, which contributes to its unique properties. The presence of multiple functional groups enhances its reactivity and versatility.
  • Applications in Medicinal Chemistry: Compounds like this one, with trione functionality, are often explored for their potential in pharmaceutical applications, particularly in the synthesis of biologically active molecules.
  • Chirality: The hydroxyl group at the 2-position introduces chirality into the molecule, which can lead to different biological activities depending on the specific enantiomer used.
  • Importance in Research: Researchers are continuously exploring similar compounds for their therapeutic benefits, particularly in areas related to cancer and metabolic disorders.
  • Potential for Synthesis: This compound can serve as an important intermediate in organic syntheses, making it a valuable building block in the development of more complex chemical entities.

As a fascinating subject of study for chemists, 5-ethyl-5-(2-hydroxy-2-phenyl-ethyl)hexahydropyrimidine-2,4,6-trione illustrates the intricate balance between structure, reactivity, and potential application. Its continued investigation is likely to yield exciting discoveries in both academic and practical chemistry.

Synonyms
15302-82-6
BARBITURIC ACID, 5-ETHYL-5-(beta-HYDROXYPHENETHYL)-
BRN 0032276
5-Ethyl-5-(beta-hydroxy-beta-phenethyl)barbituric acid
5-Etylo-5-(beta-hydroksy-beta-fenetylo)-barbiturowego [Polish]
5-25-03-00347 (Beilstein Handbook Reference)
5-Etylo-5-(beta-hydroksy-beta-fenetylo)-barbiturowego
DTXSID30934667
5-Ethyl-4,6-dihydroxy-5-(2-hydroxy-2-phenylethyl)pyrimidin-2(5H)-one