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Methohexital

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Identification
Molecular formula
C14H18N2O3
CAS number
1868-53-7
IUPAC name
5-ethyl-5-phenyl-1,3-bis(1-piperidylmethyl)hexahydropyrimidine-2,4,6-trione
State
State
Methohexital is a solid at room temperature, often encountered in powder form for pharmaceutical preparations.
Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
255.00
Boiling point (Kelvin)
528.15
General information
Molecular weight
284.31g/mol
Molar mass
284.3310g/mol
Density
1.1100g/cm3
Appearence

Methohexital is typically presented as a white, crystalline powder. It is not hygroscopic and must be protected from light and moisture to maintain its stability.

Comment on solubility

Solubility of 5-ethyl-5-phenyl-1,3-bis(1-piperidylmethyl)hexahydropyrimidine-2,4,6-trione

The solubility of 5-ethyl-5-phenyl-1,3-bis(1-piperidylmethyl)hexahydropyrimidine-2,4,6-trione can be quite complex due to its intricate structure. This compound exhibits certain characteristics that influence its solubility:

  • Polarity: The presence of polar functional groups may increase solubility in polar solvents, such as water or alcohol.
  • Hydrogen bonding: The ability of the compound to engage in hydrogen bonding can further enhance solubility in suitable solvents.
  • Non-polar characteristics: If certain areas of the compound are non-polar, this may lead to a better solubility in organic solvents like chloroform or ether.
  • Concentration: Generally, solubility can also be affected by the concentration of the compound; higher temperatures often decrease solubility in certain solvents.

As a rule of thumb, it is essential to consider the solvent's properties, such as:

  1. Dielectric constant
  2. Hydrogen bond donor and acceptor capabilities
  3. Molecular size and structure of the solvent

In conclusion, while the specific solubility of this compound may vary depending on the experimental conditions, understanding these factors can guide its effective dissolution in various media. Always remember, *solubility is a delicate balance of interactions*, making it a fascinating area of study for chemists!

Interesting facts

Exploring 5-Ethyl-5-phenyl-1,3-bis(1-piperidylmethyl)hexahydropyrimidine-2,4,6-trione

5-Ethyl-5-phenyl-1,3-bis(1-piperidylmethyl)hexahydropyrimidine-2,4,6-trione is a fascinating compound that falls within the realm of pyrimidine derivatives, which are key players in organic chemistry due to their diverse biological activities. Here are some intriguing insights into this compound:

  • Structural Features: The presence of a hexahydropyrimidine ring fused with multiple substituents gives this compound a complex arrangement that can significantly impact its reactivity and interactions with biological systems.
  • Biological Activities: Compounds containing piperidine groups, like this one, often exhibit interesting pharmacological properties, which can include effects on central nervous system activity, making them potential candidates for drug development.
  • Synthetic Challenges: The synthesis of such multi-substituted heterocycles often involves intricate reaction pathways, requiring advanced synthetic techniques. This complexity not only poses challenges but also drives innovation in synthetic organic chemistry.
  • Research Applications: Researchers are keenly interested in derivatives of hexahydropyrimidine for their potential applications in medicinal chemistry, particularly in the development of new therapeutic agents.

As noted by many chemists, "The beauty of chemistry lies not just in discovering new compounds, but in understanding their intricate behaviors and properties." This compound is a prime example of how molecular structure can influence interactions and lead to various applications in pharmaceuticals and beyond.

Overall, 5-ethyl-5-phenyl-1,3-bis(1-piperidylmethyl)hexahydropyrimidine-2,4,6-trione exemplifies the dynamic interplay of structure and function in organic compounds, paving the way for future studies and applications in chemical and medicinal research.

Synonyms
Imet 176-68
23192-91-8
DTXSID60177767
ZIMET 176-68
1,3-Bis-(piperidinomethyl-5-ethyl-5-phenylbarbituric acid)
RefChem:147941
DTXCID20100258
Zimet 176/68
1,3-Bpp
1,3-Bis(piperidinomethyl)-5-ethyl-5-phenylbarbituric acid
IMET 176/68
BRN 1608952
5-ethyl-5-phenyl-1,3-bis(piperidin-1-ylmethyl)-1,3-diazinane-2,4,6-trione
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl-1,3-bis(1-piperidinylmethyl)-
SCHEMBL29453008
BARBITURIC ACID, 1,3-BIS(PIPERIDINOMETHYL)-5-ETHYL-5-PHENYL-