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5-Fluorobenzoxazol-2-amine

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Identification
Molecular formula
C7H5FN2O
CAS number
99189-60-3
IUPAC name
5-fluoro-1,3-benzoxazol-2-amine
State
State

At room temperature, 5-Fluorobenzoxazol-2-amine is in the solid state. Its crystalline nature and relatively high melting point further corroborate its stability as a solid under normal conditions.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.00
Boiling point (Celsius)
347.80
Boiling point (Kelvin)
621.00
General information
Molecular weight
152.13g/mol
Molar mass
152.1390g/mol
Density
1.4253g/cm3
Appearence

5-Fluorobenzoxazol-2-amine appears as a crystalline solid. It is generally characterized by a fine powder format, often exhibiting a white to light grey color. Such properties are typical of many aromatic heterocyclic compounds.

Comment on solubility

Solubility of 5-fluoro-1,3-benzoxazol-2-amine

The solubility of 5-fluoro-1,3-benzoxazol-2-amine can be understood through various factors that influence how well a substance dissolves in a solvent. Key aspects to consider include:

  • Polarity: The presence of polar functional groups in the compound affects its ability to interact with polar solvents such as water.
  • Temperature: Solubility often increases with temperature; thus, higher temperatures may facilitate the dissolution of this compound.
  • pH of the solution: The solubility may vary with the pH due to protonation or deprotonation of amine groups.

In general, *5-fluoro-1,3-benzoxazol-2-amine* demonstrates moderate solubility in organic solvents, while its solubility in water might be limited, which could be attributed to:

  1. Constant structural rigidity.
  2. The influence of fluorine substituent in altering hydrogen bonding abilities.
  3. Potential aggregate formation in aqueous environments.

As a result, to better understand its practical applications and behaviors in various environments, detailed experimental data is essential. Indeed, *“solubility is the key to unlocking the potential of a compound in real-world applications.”*

Interesting facts

Interesting Facts about 5-Fluoro-1,3-benzoxazol-2-amine

5-Fluoro-1,3-benzoxazol-2-amine is a fascinating organic compound that has garnered attention in various fields of research due to its unique chemical structure and potential applications. Here are some compelling points to consider:

  • Pharmaceutical Potential: This compound belongs to a class of compounds known for their ability to interact with biological systems. Its structure suggests potential activity in medicinal chemistry, especially in the development of new drugs.
  • Biological Activity: Research has indicated that benzoxazole derivatives often exhibit a wide range of biological activities, including anti-inflammatory, antibacterial, and antifungal properties. This makes 5-fluoro-1,3-benzoxazol-2-amine an interesting candidate for further exploration in pharmacology.
  • Fluorine's Role: The presence of the fluorine atom in the compound can significantly enhance its lipophilicity, potentially leading to improved membrane permeability. As a result, compounds like this one can often show enhanced biological activity compared to their non-fluorinated counterparts.
  • Research Applications: Beyond pharmaceuticals, 5-fluoro-1,3-benzoxazol-2-amine may also find applications in materials science and organic electronics due to its intriguing electronic properties.
  • Synthetic Pathways: The synthesis of this compound involves multi-step reactions that can include condensation and substitution reactions, showcasing the versatility of synthetic organic chemistry. Chemists continuously seek efficient pathways to produce such compounds to optimize yields and reduce waste.

In summary, 5-fluoro-1,3-benzoxazol-2-amine stands out due to its potential medicinal properties, chemical versatility, and the intriguing role that fluorine plays in enhancing its characteristics. Continued research may unlock even more possibilities for this compound, making it a significant subject of interest in the scientific community.

Synonyms
1682-39-9
5-Fluorobenzo[d]oxazol-2-amine
5-fluoro-1,3-benzoxazol-2-amine
2-Amino-5-fluorobenzoxazole
2-Benzoxazolamine, 5-fluoro-
5-fluorobenzoxazol-2-amine
BENZOXAZOLE, 2-AMINO-5-FLUORO-
MFCD01664142
NSC24983
NSC 24983
WLN: T56 BN DOJ CZ HF
5-Fluoro-2-benzoxazolamine
SCHEMBL12965896
DTXSID60168534
ALBB-027302
NSC-24983
5-fluoranyl-1,3-benzoxazol-2-amine
AKOS011653546
AB09694
AS-50432
SY130059
DB-027774
CS-0054542
EN300-96706
P10198
A810953
F2147-1908
Z979487600
5-fluoro-1,3-benzoxazol-2-amine;2-Amino-5-fluorobenzoxazole
V2R