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5-Fluoro-2-[(2-methyl-3,4-dihydroisoquinolin-1-yl)methyl]aniline

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Identification
Molecular formula
C17H19FN2
CAS number
143779-17-7
IUPAC name
5-fluoro-2-[(2-methyl-3,4-dihydro-1H-isoquinolin-1-yl)methyl]aniline
State
State

At room temperature, this compound is in a solid state.

Melting point (Celsius)
75.50
Melting point (Kelvin)
348.65
Boiling point (Celsius)
530.63
Boiling point (Kelvin)
803.78
General information
Molecular weight
258.32g/mol
Molar mass
258.3190g/mol
Density
1.1867g/cm3
Appearence

The compound is typically a solid at room temperature and appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 5-fluoro-2-[(2-methyl-3,4-dihydro-1H-isoquinolin-1-yl)methyl]aniline

The solubility of the compound 5-fluoro-2-[(2-methyl-3,4-dihydro-1H-isoquinolin-1-yl)methyl]aniline is an important consideration in its application and use in various contexts. Its solubility is influenced by several factors:

  • Polarity: Due to the presence of both aromatic amine and fluorine groups, the compound shows varying degrees of polarity.
  • Hydrogen Bonding: The amine group enables hydrogen bonding with water, which can enhance solubility.
  • Alkyl Substitution: The 2-methyl group may impact steric hindrance and, therefore, affects the solubility behavior.

Generally, compounds similar to this structure tend to exhibit:

  • Moderate Solubility in Water: Some degree of solubility can be expected, though not entirely soluble.
  • Higher Solubility in Organic Solvents: It may dissolve more readily in polar organic solvents.

As noted, the overall solubility can vary significantly based on environmental conditions and the presence of other solutes. It is often summarized that “the solubility of a compound can greatly influence its biological activity and pharmacokinetics.” Understanding these solubility properties is crucial for the successful application of this compound in medicinal chemistry and related fields.

Interesting facts

Interesting Facts about 5-fluoro-2-[(2-methyl-3,4-dihydro-1H-isoquinolin-1-yl)methyl]aniline

This fascinating compound, known as 5-fluoro-2-[(2-methyl-3,4-dihydro-1H-isoquinolin-1-yl)methyl]aniline, belongs to a class of compounds with significant implications in medicinal chemistry. It showcases the beauty of organic synthesis and the potential of *fluorinated compounds* in drug design.

Key Highlights:

  • Fluorine's Role: The presence of fluorine in organic compounds often enhances their biological activity and metabolic stability. This compound is no exception; its fluorine substitution can increase lipophilicity, leading to better membrane permeability.
  • Isoquinoline Derivative: The isoquinoline structure is commonly found in various bioactive compounds, making this derivative particularly interesting for pharmaceutical research. It may have implications in treating neurological disorders due to the pharmacological properties associated with isoquinoline derivatives.
  • Diversity of Applications: Compounds that feature aniline and isoquinoline moieties have been studied for their potential as anti-cancer agents, anti-inflammatory drugs, and for their effects on the central nervous system.

Scientists and researchers are often drawn to the intricate structures of compounds like this one, appreciating their potential in task-oriented syntheses and their ability to inspire novel drug development. As you explore this compound further, consider its *chemical behavior*, *synthesis pathways*, and *therapeutic applications*. The world of organic chemistry is vast, and each compound tells a unique story of innovation and discovery.