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5-Fluoro-2-nitrophenol

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Identification
Molecular formula
C6H4FNO3
CAS number
446-36-6
IUPAC name
5-fluoro-2-nitro-phenol
State
State

At room temperature, 5-fluoro-2-nitrophenol is a solid. It maintains structural stability under ambient conditions, making it manageable for laboratory applications but requires careful handling due to its potential reactivity because of the nitro group.

Melting point (Celsius)
69.00
Melting point (Kelvin)
342.15
Boiling point (Celsius)
242.20
Boiling point (Kelvin)
515.35
General information
Molecular weight
173.10g/mol
Molar mass
173.1160g/mol
Density
1.4770g/cm3
Appearence

5-Fluoro-2-nitrophenol is a yellow crystalline solid. Due to its aromatic structure, the compound exhibits the typical characteristics of nitro-substituted aromatic compounds. The presence of a nitro group contributes strongly to its color and overall chemical behavior.

Comment on solubility

Solubility of 5-fluoro-2-nitro-phenol

When examining the solubility of 5-fluoro-2-nitro-phenol, several key factors come into play due to its distinctive chemical structure.

This compound, characterized by the presence of both a fluoro group and a nitro group on the phenolic ring, exhibits unique solubility characteristics:

  • Polarity: The presence of electronegative atoms (like fluorine and nitrogen) enhances the overall polarity of the compound, which may improve its solubility in polar solvents.
  • Hydrogen Bonding: As a phenolic compound, 5-fluoro-2-nitro-phenol can participate in hydrogen bonding, potentially increasing its solubility in water.
  • Solvent Interaction: It is more likely to be soluble in organic solvents such as alcohols and ethers compared to non-polar solvents, due to its functional groups.

However, it is crucial to note that the exact solubility can vary based on:

  • Temperature:
    Higher temperatures generally increase solubility.
  • pH Levels:
    The ionization of the hydroxyl group in varying pH conditions can also affect solubility.

In summary, while 5-fluoro-2-nitro-phenol shows potential for solubility in both polar and non-polar solvents, one must consider its specific functional groups and environmental conditions. As stated, "*the interplay of chemical structure and interactions with solvents ultimately determines solubility*." Thus, empirical testing and further literature review are advisable to ascertain its precise behavior in various media.

Interesting facts

Interesting Facts about 5-Fluoro-2-nitro-phenol

5-Fluoro-2-nitro-phenol is a fascinating compound that falls under the category of halogenated nitrophenols. This unique structure gives it distinctive chemical properties and a wide array of applications. Here are some interesting insights:

  • Functional Groups: The presence of both a nitro group (−NO2) and a fluoro substituent (−F) on the phenolic ring significantly influences its chemical reactivity and interactions with other compounds.
  • Environmental Applications: This compound is examined for its potential role in environmental chemistry, particularly in studies concerning pollutants. Its halogen and nitro groups often lead to interesting patterns of toxicity and degradation.
  • Pharmaceutical Research: The fluorination of organic compounds like 5-fluoro-2-nitro-phenol can enhance their bioactivity. In medicinal chemistry, fluorinated compounds are known to exhibit improved metabolic stability and binding affinity, making them promising candidates in drug development.
  • Safety and Handling: As with many nitro compounds, special care is essential when handling 5-fluoro-2-nitro-phenol. Its potential environmental impacts underscore the need for responsible usage and disposal.
  • Research Significance: Scientists continue to study compounds like 5-fluoro-2-nitro-phenol in the quest to develop new materials and chemicals, showcasing the relevance of its unique structure in modern chemical research.

Moreover, the exploration of its properties can inspire innovations in both synthetic and applied chemistry. As you delve deeper into the fascinating realm of chemical compounds, the journey of 5-fluoro-2-nitro-phenol certainly reminds us of the intricate balance between structure and function in the molecular world.

Synonyms
5-FLUORO-2-NITROPHENOL
446-36-6
3-Fluoro-6-nitrophenol
2-Nitro-5-Fluorophenol
Phenol, 5-fluoro-2-nitro-
MFCD00007107
EINECS 207-168-6
NSC 10284
6E7F47EK4J
DTXSID40196239
NSC-10284
5-Fluoro-2-nitro-phenol
3-fluoro 6-nitrophenol
5-flouro-2-nitrophenol
2-nitro-5-fluoro-phenol
3-fluoro 6-nitro phenol
5-fluoro-2-nitro phenol
UNII-6E7F47EK4J
SCHEMBL39862
2-hydroxy-4-fluoronitrobenzene
5-Fluoro-2-nitrophenol, 99%
DTXCID00118730
4-fluoro-2-hydroxy-1-nitrobenzene
NSC10284
BBL011551
STL146685
AKOS000120905
AB00840
AC-2472
CS-W008895
FF70571
AS-13222
DB-024042
F0224
NS00042913
EN300-20009
F0001-1216
Z104476374
207-168-6