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5-Fluoro-AMT

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Identification
Molecular formula
C13H15FN2
CAS number
57801-95-3
IUPAC name
5-fluoro-3-(1-methylpyrrolidin-2-yl)-1H-indole
State
State

At room temperature, 5-Fluoro-AMT is typically found as a solid. It is known to be stable under standard conditions, but it should be stored away from light and heat to maintain its integrity.

Melting point (Celsius)
102.00
Melting point (Kelvin)
375.15
Boiling point (Celsius)
383.20
Boiling point (Kelvin)
656.35
General information
Molecular weight
218.27g/mol
Molar mass
218.2580g/mol
Density
1.2040g/cm3
Appearence

5-Fluoro-AMT typically appears as an off-white or light brown crystalline solid. Its form can be slightly granular or powdery based on the level of synthesis and purity.

Comment on solubility

Solubility of 5-fluoro-3-(1-methylpyrrolidin-2-yl)-1H-indole

The solubility of 5-fluoro-3-(1-methylpyrrolidin-2-yl)-1H-indole is an intriguing aspect due to its unique structure and functional groups. Usually, solubility in a solvent can be influenced by several factors, including:

  • Polarity: The presence of a fluorine atom in the compound may affect its overall polarity, potentially enhancing solubility in polar solvents.
  • Hydrogen Bonding: The 1-methylpyrrolidin-2-yl moiety may participate in hydrogen bonding, promoting solubility in protic solvents.
  • Hydrophobic Interactions: The indole ring can introduce hydrophobic character, influencing solubility in organic solvents.
  • pH Sensitivity: As with many nitrogen-containing compounds, its solubility can be affected by pH levels, often becoming more soluble in acidic or basic solutions.

However, specific solubility values in common solvents (like water, ethanol, or dimethyl sulfoxide) are not universally established and may vary based on the formulation or synthesis method. Thus, it's vital to approach the practical applications of this compound with an understanding of its solubility profile under different conditions.

In conclusion, the solubility of 5-fluoro-3-(1-methylpyrrolidin-2-yl)-1H-indole warrants further investigation for optimal application, especially in pharmacological contexts where solubility plays a crucial role in bioavailability and efficacy.

Interesting facts

Interesting Facts about 5-Fluoro-3-(1-methylpyrrolidin-2-yl)-1H-indole

5-Fluoro-3-(1-methylpyrrolidin-2-yl)-1H-indole is a fascinating compound that has garnered attention for its unique structure and potential applications. Here are some intriguing aspects of this compound:

  • Pharmacological Potential: This compound has been studied for its possible therapeutic benefits. Its structural similarities to other biologically active molecules suggest it may have antipsychotic or antidepressant properties.
  • Fluorine's Influence: The incorporation of a fluorine atom can significantly influence the compound's pharmacokinetic properties, potentially enhancing its bioavailability and membrane permeability.
  • Indole Framework: The indole moiety is well-known in medicinal chemistry, serving as a core structure for a variety of drugs including antibiotics and anti-cancer agents. This highlights its versatility and importance in drug design.
  • Role in Neuroscience: Indole derivatives, including this compound, are of particular interest in neuroscience due to their interactions with neurotransmitter systems, particularly those involving serotonin.
  • Synthesis Challenges: The synthesis of 5-fluoro-3-(1-methylpyrrolidin-2-yl)-1H-indole can be quite complex, requiring specialized techniques in organic chemistry to ensure the purity and yield of the final product.

In summary, 5-fluoro-3-(1-methylpyrrolidin-2-yl)-1H-indole represents a compelling intersection of structure and activity in medicinal chemistry. Its unique characteristics make it a subject of ongoing research and an exciting compound for future discoveries.

Synonyms
1815-29-8
5-fluoro-3-(1-methylpyrrolidin-2-yl)-1H-indole
5-Fluoro-3-(1-methyl-2-pyrrolidinyl)-1H-indole
BRN 0524759
5-Fluoro-3-(1-methyl-2-pyrroldinyl)indole
INDOLE, 5-FLUORO-3-(1-METHYL-2-PYRROLIDINYL)-
DTXSID40939441