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5-Fluoro-3-phenyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-indole

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Identification
Molecular formula
C25H23FN2O
CAS number
1236128-87-4
IUPAC name
5-fluoro-3-phenyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-indole
State
State

The compound is typically in a solid state at room temperature.

Melting point (Celsius)
142.00
Melting point (Kelvin)
415.15
Boiling point (Celsius)
453.20
Boiling point (Kelvin)
726.35
General information
Molecular weight
399.48g/mol
Molar mass
399.4790g/mol
Density
1.2932g/cm3
Appearence

The compound is typically seen as a crystalline solid. It may appear as a white or off-white powder depending on the purity.

Comment on solubility

Solubility of 5-fluoro-3-phenyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-indole

The solubility characteristics of 5-fluoro-3-phenyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-indole can be quite complex due to its unique structure and functional groups. Understanding solubility is crucial for both research and practical applications in pharmaceuticals and material science. Here are some important aspects to consider:

  • Polarity: The presence of the pyrrolidine and ethoxy groups often increases polarity, suggesting potential interaction with polar solvents such as water.
  • Hydrophobic regions: The indole and phenyl groups contribute significantly to hydrophobicity, which may limit solubility in aqueous environments.
  • Solvent Compatibility: This compound may be better soluble in organic solvents like ethanol or DMSO rather than in water due to its hydrophobic nature.
  • Temperature Effects: Generally, an increase in temperature may enhance the solubility of organic compounds—a critical factor during experimental procedures.

As with many organic compounds, it is often found that a balance between hydrophilic and hydrophobic characteristics dictates the overall solubility profile. It’s essential to perform solubility tests in different solvents to achieve a comprehensive understanding, ensuring the right conditions are identified for optimal use.

Interesting facts

Interesting Facts about 5-Fluoro-3-phenyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-indole

This intriguing compound, known as 5-fluoro-3-phenyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-indole, is a part of the indole family, a class of compounds well-regarded for their diverse biological activities. Here are some fascinating insights related to this compound:

  • Pharmacological Significance: Many indole derivatives exhibit remarkable pharmacological properties, including anti-inflammatory, analgesic, and anti-cancer effects. The presence of the fluorine atom in this compound may enhance its biological activity by increasing lipophilicity and metabolic stability.
  • Indole Structure: The indole moiety is critical in medicinal chemistry due to its ability to mimic natural products, making it a vital scaffold for drug development.
  • Pyrrolidine Interaction: The pyrrolidine group attached to the phenyl structure could influence receptor interactions, making it a target for further research in neuropharmacology.
  • Research Potential: Ongoing studies on similar compounds have indicated potential as neuromodulators, thus opening doors for innovations in treating neurological disorders.
  • Aesthetic in Chemical Design: The complexity of this compound's structure exemplifies how chemistry blends art and science, allowing chemists to design molecules that are both aesthetically pleasing and functionally potent.

In the words of renowned chemist Linus Pauling, "The best way to have a good idea is to have lots of ideas." This compound serves as a reminder of the endless possibilities that arise from exploring complex chemical structures.

As research in medicinal chemistry advances, compounds like 5-fluoro-3-phenyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-indole highlight the importance of intricate chemical interactions and their implications for future therapies.

Synonyms
7720-62-9
INDOLE, 5-FLUORO-3-PHENYL-2-(p-(2-(1-PYRROLIDINYL)ETHOXY)PHENYL)-
Indole, 5-fluoro-3-phenyl-2-[p-[2-(1-pyrrolidinyl)ethoxy]phenyl]-
5-Fluoro-3-phenyl-2-p-(beta-pyrrolidinoethoxy)phenylindole
5-Fluoro-2-(p-(beta-pyrrolidinoethoxy)phenyl)-3-phenylindole
F9Y3TVH7YZ
DTXSID80227955
1H-Indole, 5-fluoro-3-phenyl-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-
5-Fluoro-3-phenyl-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-1H-indole