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Camptothecin

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Identification
Molecular formula
C20H16N2O4
CAS number
7689-03-4
IUPAC name
5-hydroxy-4,15,16-trimethoxy-10-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(17),2,4,6,9,11,13,15-octaen-8-one
State
State

Camptothecin is typically a solid at room temperature. It is found as a crystalline powder that is stable under standard conditions.

Melting point (Celsius)
267.00
Melting point (Kelvin)
540.15
Boiling point (Celsius)
548.20
Boiling point (Kelvin)
821.35
General information
Molecular weight
348.35g/mol
Molar mass
348.3520g/mol
Density
1.2996g/cm3
Appearence

Camptothecin usually appears as a pale yellow crystalline powder. It is quite insoluble in water but soluble in organic solvents. The compound has a characteristic color and crystalline form making it identifiable.

Comment on solubility

Solubility of 5-hydroxy-4,15,16-trimethoxy-10-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(17),2,4,6,9,11,13,15-octaen-8-one

The solubility of 5-hydroxy-4,15,16-trimethoxy-10-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(17),2,4,6,9,11,13,15-octaen-8-one can be quite complex due to its unique molecular structure and functional groups. Understanding the solubility behavior is essential for both practical applications and theoretical investigations. Here are several key points to consider:

  • Polarity: This compound contains multiple functional groups, including hydroxy and methoxy groups, which contribute to its overall polarity. Polar compounds tend to be more soluble in polar solvents, such as water.
  • Hydrogen Bonding: The presence of hydroxyl groups allows the compound to form hydrogen bonds with solvents, enhancing solubility particularly in alcohols and other hydrogen-bonding solvents.
  • Solvent Compatibility: It is anticipated to have limited solubility in non-polar solvents like hydrocarbons, while being more soluble in moderately polar solvents due to the methoxy groups.
  • Concentration Dependance: As with many complex organic compounds, solubility may also vary significantly with concentration and temperature, highlighting the need for specific studies under varied conditions.

In conclusion, the solubility of 5-hydroxy-4,15,16-trimethoxy-10-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(17),2,4,6,9,11,13,15-octaen-8-one could be summarized as the interplay of its polar functionalities and the resultant hydrogen bonding effects. Further empirical studies are needed to quantify its solubility in various solvents for comprehensive characterization.

Interesting facts

Interesting Facts about 5-Hydroxy-4,15,16-trimethoxy-10-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(17),2,4,6,9,11,13,15-octaen-8-one

This complex compound, more commonly referred to in a shortened form, has garnered attention for its unique structure and potential applications in various fields. Here are some interesting facts:

  • Structural Complexity: The compound features a distinctive tetracyclic structure that is part of its unique chemical identity.
  • Natural Product: It is believed to be derived from natural sources, typically found in certain plants, showcasing the rich diversity of organic compounds in nature.
  • Potential Biological Activities: The presence of multiple methoxy groups and a hydroxyl group hints at possible biological activities, making it a candidate for pharmacological studies. Research has suggested that compounds with similar structures can exhibit anti-inflammatory and antioxidant properties.
  • Interaction with Biological Systems: The azatetracyclic structure may influence how the compound interacts with proteins and enzymes, thereby affecting its biological activities.
  • Research Interest: Ongoing studies are focused on understanding its medicinal properties, with a particular emphasis on how its potent chemical features could lead to new therapeutic agents.
  • Synthetic Challenges: The synthesis of this compound can be quite challenging due to its intricate structure, making it a subject of interest for chemists specializing in organic synthesis.

As expressed by chemists, "Exploring the vast world of organic compounds often uncovers hidden treasures with immense potential." This compound is a prime example of such a treasure, blending complexity with prospects in scientific research.

Synonyms
Atheroline
Atheriline
5140-35-2
BRN 1628053
4,5,6,6a-Tetradehydro-9-hydroxy-1,2,10-trimethoxynoraporphin-7-one
7H-Dibenzo(de,g)quinolin-7-one, 9-hydroxy-1,2,10-trimethoxy-
NORAPORPHIN-7-ONE, 4,5,6,6a-TETRADEHYDRO-9-HYDROXY-1,2,10-TRIMETHOXY-
7H-Dibenzo[de,g]quinolin-7-one, 9-hydroxy-1,2,10-trimethoxy-
5-hydroxy-4,15,16-trimethoxy-10-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(17),2,4,6,9,11,13,15-octaen-8-one
9-Hydroxy-1,2,10-trimethoxy-7H-dibenzo[de,g]quinolin-7-one
5-21-13-00666 (Beilstein Handbook Reference)
CHEBI:2906
DTXSID70965718
VITQCDLNBVTCJS-UHFFFAOYSA-N
AKOS040750620
C09343
Q27105876
1,2,10-Trimethoxy-6H-dibenzo[de,g]quinoline-7,9-dione
9-Hydroxy-1,2,10-trimethoxy-7H-dibenzo[de,g]quinolin-7-one #