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5-Hydroxypyridine-3-carboxylic acid

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Identification
Molecular formula
C6H5NO3
CAS number
603-64-1
IUPAC name
5-hydroxypyridine-3-carboxylic acid
State
State

This compound is a solid at room temperature under normal conditions.

Melting point (Celsius)
211.00
Melting point (Kelvin)
484.15
Boiling point (Celsius)
496.00
Boiling point (Kelvin)
769.15
General information
Molecular weight
139.11g/mol
Molar mass
139.1110g/mol
Density
1.4158g/cm3
Appearence

5-Hydroxypyridine-3-carboxylic acid typically appears as a yellowish solid. It has a crystalline form and is often found in powdered form for laboratory use.

Comment on solubility

Solubility of 5-hydroxypyridine-3-carboxylic Acid

5-hydroxypyridine-3-carboxylic acid, often referred to as a derivative of pyridine, exhibits notable solubility characteristics that can be influenced by various factors. Here are some key points regarding its solubility:

  • Solvent Dependency: This compound is generally soluble in polar solvents such as water and methanol. The presence of both a hydroxyl group and a carboxylic acid group enhances its ability to form hydrogen bonds.
  • Limitations in Solubility: In non-polar solvents, 5-hydroxypyridine-3-carboxylic acid's solubility significantly decreases. This highlights the compound's preference for environments where interactions with polar molecules can occur.
  • pH Influence: The solubility of this acid can also vary with pH. In acidic conditions, the carboxyl group can remain protonated, potentially affecting overall solubility compared to neutral or basic conditions.
  • Temperature Effects: Warmer temperatures often increase solubility for such organic compounds, making solubility a temperature-dependent property.

Overall, the solubility of 5-hydroxypyridine-3-carboxylic acid is a vital aspect that affects its utilization in various chemical processes. Understanding these solubility traits not only aids in practical applications but also enriches our knowledge of the compound's chemical behavior.

Interesting facts

Interesting Facts about 5-Hydroxypyridine-3-Carboxylic Acid

5-Hydroxypyridine-3-carboxylic acid, often referred to as 5-HO-PCA, is a fascinating compound that draws interest from both researchers and students alike. This compound is notable for its versatile applications and significant biological properties. Here are some engaging facts about this intriguing chemical:

  • Biological Importance: 5-HO-PCA is known for its role in various biological processes. It acts as a precursor in the synthesis of several important biomolecules, contributing to metabolic pathways.
  • Pharmacological Applications: The compound has garnered attention in the field of pharmacology for its potential therapeutic effects. Studies have suggested it may possess anti-inflammatory and antioxidant properties.
  • Synthesis Methods: There are multiple methods for synthesizing 5-HO-PCA; the most common involves the reaction of pyridine derivatives with hydroxylating agents. This showcases the versatility of organic synthesis techniques.
  • Analytical Chemistry: 5-HO-PCA is often studied using sophisticated techniques such as chromatography and spectroscopy, making it an appealing compound for students learning analytical methods.
  • Cultural Relevance: Pyridine derivatives, including 5-HO-PCA, are pivotal in **medicinal chemistry** and have influenced the design of various pharmaceuticals. Understanding these compounds opens doors to innovations in drug development.

As a compound with diverse applications and intriguing properties, 5-hydroxypyridine-3-carboxylic acid continues to be a subject of research in biochemical and pharmacological settings. A quote from a noted chemist encapsulates this sentiment: "The journey into the molecular world reveals the subtle yet powerful role of each compound, like 5-HO-PCA, in the tapestry of life."

Engaging with 5-HO-PCA not only enhances one's chemical knowledge but also bridges the gap between basic chemistry and real-world applications, demonstrating the profound impact of small molecules in research and development.

Synonyms
5-Hydroxynicotinic acid
27828-71-3
5-Hydroxy-3-pyridinecarboxylic acid
DTXSID50182143
RefChem:102920
DTXCID60104634
622-583-6
5-hydroxypyridine-3-carboxylic acid
3-Pyridinecarboxylic acid, 5-hydroxy-
MFCD00129117
5-Hydroxy-nicotinic acid
5-hydroxy nicotinic acid
CHEMBL2146902
5-hydroxynicotinicacid
BRN 0115847
5HN
NICOTINIC ACID, 5-HYDROXY-
Oprea1_058796
Oprea1_193943
5-22-05-00113 (Beilstein Handbook Reference)
SCHEMBL186161
5-Hydroxynicotinic acid, 97%
SCHEMBL6744448
SCHEMBL29954688
5-hydroxypyridinium-3-carboxylate
CHEBI:169995
HMS1671H22
BCP27371
BBL010930
BDBM50391823
NSC606891
SBB010273
STK531022
STK801985
AKOS000272822
AKOS005463460
AC-2839
CS-W009148
NSC-606891
PB33816
PS-5446
NCGC00342404-01
3-?Pyridinecarboxylic acid, 5-?hydroxy-
BP-21442
SY003082
DB-009085
H1226
NS00014692
ST50258394
EN300-73559
AB01334129-02
828H713
AE-848/00984004
F028834
Q27455772
Z57124104
5-Hydroxy-3-pyridinecarboxylic acid; 5-Hydroxypyridine-3-carboxylic acid