5-Iodo-2-thiouracil | Solubility of Things

Identification

Molecular formula

C₄H₃IN₂OS

CAS number

7308-76-9

IUPAC name

5-iodo-2-sulfanyl-1H-pyrimidin-6-one

State

At room temperature, 5-Iodo-2-thiouracil is a solid.

Melting point (Celsius)

330.00

Melting point (Kelvin)

603.00

Boiling point (Celsius)

350.00

Boiling point (Kelvin)

623.00

General information

Molecular weight

239.06g/mol

Molar mass

239.0590g/mol

Density

3.0200g/cm³

Appearence

5-Iodo-2-thiouracil is a pale yellow crystalline solid.

Comment on solubility

Solubility of 5-iodo-2-sulfanyl-1H-pyrimidin-6-one

5-iodo-2-sulfanyl-1H-pyrimidin-6-one is an intriguing compound, particularly when considering its solubility characteristics. Solubility is a fundamental property that can influence the compound’s behavior in various environments. Here are some key points to consider:

Polar vs. Non-polar Solvents: The presence of the sulfanyl group (-SH) and the iodide atom in 5-iodo-2-sulfanyl-1H-pyrimidin-6-one suggests that it may exhibit moderate solubility in polar solvents like water and alcohols due to hydrogen bonding capabilities.
Influence of Functional Groups: The electron-withdrawing nature of the iodine atom can enhance the compound's reactivity and may also affect its solubility in various solvents. This usually translates to better solubility in solvent systems where interactions can be maximized.
Hydrogen Bonding: With the functional groups present, this compound is likely capable of engaging in hydrogen bonding, which can improve solubility in polar environments.

However, it is important to note that specific solubility data may be limited or variable based on synthesis methods and purity levels. In summary, while we can anticipate certain behaviors in solubility, experimental verification under controlled conditions is essential to provide concrete data for practical applications.

Interesting facts

Interesting Facts about 5-Iodo-2-sulfanyl-1H-pyrimidin-6-one

5-Iodo-2-sulfanyl-1H-pyrimidin-6-one is a fascinating compound belonging to the class of pyrimidines, which are aromatic heterocycles containing nitrogen atoms in their structure. This specific compound offers several intriguing aspects:

Biological Activity: Pyrimidine derivatives like 5-iodo-2-sulfanyl-1H-pyrimidin-6-one often exhibit significant biological activities. They are known for their roles in medicinal chemistry, with some compounds showing potential as antiviral, anticancer, or antimicrobial agents.
Structural Diversity: The presence of both iodine and a sulfur atom in its structure contributes to the compound's unique properties. This combination can enhance reactivity and influence how the compound interacts with biological targets:

Iodine: This halogen can make the compound more lipophilic, potentially improving its ability to penetrate biological membranes.
Sulfanyl Group: The thiol (-SH) group is known for its ability to form disulfide bonds, which can be crucial in biological systems, especially in protein folding and function.

Research Interests: Due to its unique structure, 5-iodo-2-sulfanyl-1H-pyrimidin-6-one is of interest in various fields of research, including:

Drug Discovery: Researchers are continually exploring its potential as a lead compound.
Material Science: Understanding its electronic properties can lead to new applications in electronics or photonics.

Synthetic Routes: Chemists have developed numerous synthetic pathways to produce this compound, highlighting the versatility in reaction conditions and reagents. The synthesis often employs methods that allow for the selective introduction of the iodine and sulfur atoms.

In summary, 5-iodo-2-sulfanyl-1H-pyrimidin-6-one is not just a chemical entity; it represents a rich area of study with implications in pharmacology and material science. As researchers continue to dissect its properties and applications, we can expect to unveil even more about the intriguing world of pyrimidine derivatives.