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Thiopental

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Identification
Molecular formula
C11H18N2O3
CAS number
76-75-5
IUPAC name
5-isopropyl-1,5-dimethyl-hexahydropyrimidine-2,4,6-trione
State
State

Thiopental is a solid at room temperature. It is usually found in powdered form, which can be reconstituted into a liquid for use as an intravenous anesthetic.

Melting point (Celsius)
158.00
Melting point (Kelvin)
431.00
Boiling point (Celsius)
196.00
Boiling point (Kelvin)
469.00
General information
Molecular weight
264.36g/mol
Molar mass
264.3630g/mol
Density
1.3000g/cm3
Appearence

Thiopental is typically a white crystalline powder. It may also appear as fine needles. It is known for its distinct aromatic odor and has a sharp, bitter taste. When in solution form, it appears as a clear liquid.

Comment on solubility

Solubility of 5-isopropyl-1,5-dimethyl-hexahydropyrimidine-2,4,6-trione

5-isopropyl-1,5-dimethyl-hexahydropyrimidine-2,4,6-trione exhibits interesting solubility characteristics which can be impacted by various factors such as temperature and pH levels. Here are some key aspects:

  • Solvent Compatibility: This compound shows variable solubility in polar solvents, indicating it may dissolve well in water or alcohols due to the presence of the *carbonyl groups* which can engage in hydrogen bonding.
  • Temperature Influence: Generally, increasing temperature can enhance the solubility of solid compounds in solvents. For 5-isopropyl-1,5-dimethyl-hexahydropyrimidine-2,4,6-trione, higher temperatures may increase its dissolution rate, allowing for more effective use in chemical reactions.
  • pH Sensitivity: The solubility may also be affected by the pH of the solution. In certain conditions (like more alkaline environments), the solubility can improve due to the deprotonation of functional groups.

As a general observation, understanding the solubility of 5-isopropyl-1,5-dimethyl-hexahydropyrimidine-2,4,6-trione is crucial for its applications, whether in synthesis or pharmaceuticals. As the saying goes, “The solvent defines the solution!” Thus, selecting the right solvent can play a pivotal role in effectively utilizing this compound.

Interesting facts

Interesting Facts about 5-Isopropyl-1,5-dimethyl-hexahydropyrimidine-2,4,6-trione

5-Isopropyl-1,5-dimethyl-hexahydropyrimidine-2,4,6-trione is an intriguing compound that belongs to the class of pyrimidine derivatives. Pyrimidines are aromatic heterocycles that play significant roles in biology and pharmacology. The contribution of this specific derivative to scientific research is noteworthy because of its potential applications in various fields.

Key Highlights:

  • Versatile Building Block: This compound can serve as an important intermediate in the synthesis of biologically active molecules, particularly in medicinal chemistry.
  • Unique Structure: The presence of multiple substituents on its pyrimidine ring, including isopropyl and dimethyl groups, enhances its chemical reactivity and solubility in various solvents.
  • Potential Biological Activity: Research has suggested potential uses of pyrimidine derivatives in developing anti-inflammatory or antimicrobial agents.
  • Link to Nucleic Acids: Pyrimidines are crucial for DNA and RNA synthesis, and understanding their derivatives can provide insights into genetic processes.
  • Research Relevance: It is in the spotlight of organic synthesis studies, particularly in the field of drug discovery and development.

Furthermore, the intriguing nature of 5-isopropyl-1,5-dimethyl-hexahydropyrimidine-2,4,6-trione lies in its ability to inspire novel synthetic approaches. As noted by chemists, "Exploring the diverse chemical landscapes offered by substituted pyrimidines can lead to groundbreaking discoveries in pharmaceutical science." The continued investigation of this compound could unravel new therapeutic avenues, making it a fascinating subject for both researchers and students alike.

Synonyms
1,5-Dimethyl-5-isopropylbarbituric acid
4336-85-0
BRN 0185909
BARBITURIC ACID, 1,5-DIMETHYL-5-ISOPROPYL-
DTXSID60962998
6-Hydroxy-3,5-dimethyl-5-(propan-2-yl)pyrimidine-2,4(3H,5H)-dione