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5-Methoxyindole-2-carboxylic acid

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Identification
Molecular formula
C10H9NO3
CAS number
1777-36-0
IUPAC name
5-methoxy-1H-indole-2-carboxylic acid
State
State

At room temperature, 5-methoxyindole-2-carboxylic acid is in a solid state. It is generally handled as a powder or crystalline material and should be stored in a cool, dry place to maintain its stability.

Melting point (Celsius)
206.00
Melting point (Kelvin)
479.15
Boiling point (Celsius)
548.20
Boiling point (Kelvin)
821.35
General information
Molecular weight
191.18g/mol
Molar mass
191.1800g/mol
Density
1.3580g/cm3
Appearence

5-Methoxyindole-2-carboxylic acid appears typically as a solid. It may present as a crystalline powder that is off-white or slightly yellowish in color. Depending on purity and specific form, its appearance might slightly vary.

Comment on solubility

Solubility of 5-methoxy-1H-indole-2-carboxylic acid

5-methoxy-1H-indole-2-carboxylic acid, a compound characterized by its unique structure, displays intriguing solubility properties.

Generally, the solubility of this compound can be influenced by various factors:

  • Polarity: The presence of the carboxylic acid functional group enhances its ability to interact with polar solvents like water.
  • Solvent Choice: In organic solvents such as ethanol and methanol, it typically shows improved solubility due to favorable interactions.
  • pH Dependence: The solubility in water can vary significantly with pH; for instance, at lower pH levels, the compound may exist in its protonated form, increasing its solubility.

Furthermore, it is important to highlight that:

  1. The solubility behavior is crucial for applications in drug formulation.
  2. Understanding the solubility can lead to better insights into its reactivity and interaction with biological systems.

In summary, while 5-methoxy-1H-indole-2-carboxylic acid exhibits significant solubility in certain conditions, these solubility characteristics are fundamental for its practical applications. As the saying goes, "solubility is the key to unlocking a compound's potential."

Interesting facts

Interesting Facts About 5-Methoxy-1H-Indole-2-Carboxylic Acid

5-Methoxy-1H-indole-2-carboxylic acid, a notable compound in organic chemistry, is often recognized for its intriguing structure and diverse applications. This compound, derived from the indole framework, is not just a fascinating example of ring structures but also plays a significant role in various biological and chemical contexts.

Key Highlights

  • Biological Significance: Compounds like 5-methoxy-1H-indole-2-carboxylic acid are often studied for their potential therapeutic properties. Researchers are exploring its role in modulating neuroactivity and potential anticancer effects.
  • Indole Derivative: As an indole derivative, it shares properties with many alkaloids, which are known for their complex pharmacological effects, including analgesic and anti-inflammatory actions.
  • Synthetic Applications: The unique methoxy group in this compound serves as a useful functional handle in organic synthesis, allowing for various functionalization strategies.
  • Research Interest: The compound has garnered interest in materials science for its potential use in the development of electronic devices and photonic applications.

Exploration in Chemistry

As a chemistry student or enthusiast, delving into the synthetic methodologies to create 5-methoxy-1H-indole-2-carboxylic acid can be both enlightening and rewarding. The interplay between its structure and properties makes it an excellent candidate for studying structure-activity relationships in medicinal chemistry.

As a part of the broader indole family, this compound underscores the versatility of nitrogen-containing heterocycles in designing new pharmaceutical agents and innovative materials. Its journey from natural product to a well-characterized synthetic compound exemplifies the dynamic nature of modern chemistry and the continuous pursuit of new discoveries.

Synonyms
5-Methoxyindole-2-carboxylic acid
4382-54-1
5-Methoxy-1H-indole-2-carboxylic acid
INDOLE-2-CARBOXYLIC ACID, 5-METHOXY-
NSC 30927
EINECS 224-487-6
AFK8L54HA2
NSC-30927
CHEBI:133222
DTXSID40195944
5-Methoxy-2-indolate
5-Methoxy-2-indolecarboxylate
5-Methoxyindole-2-carboxylate
DTXCID80101847
DTXCID80118435
224-487-6
dtxsid50179356
yebjvslnumzxrj-uhfffaoysa-n
1H-Indole-2-carboxylic acid, 5-methoxy-
MFCD00005614
5-Methoxy-2-indolecarboxylic acid
Acide methoxy-5 indole carboxylique-2
Acide methoxy-5 indole carboxylique-2 [French]
NSC30927
5-METHOXYINDOLE-2-CARBOXYLICACID
5-METHOXYINDOL-2-CARBOXYLIC ACID
5-methoxy-2-indolic acid
UNII-AFK8L54HA2
Oprea1_206851
CBDivE_015623
CHEMBL23961
SCHEMBL335235
5-methoxyindole-2-carboxilic acid
HMS1613F05
5-methoxylindole-2-carboxylic Acid
5-Methoxy-indole-2-carboxylic acid
ALBB-000151
2-Indolecarboxylic acid, 5-methoxy-
BBL010666
STK386884
AKOS000265769
AC-9836
CCG-112235
CS-W010727
FM02162
SB14717
5-Methoxy-1-H-indole-2-carboxylic acid
5-Methoxyindole-2-carboxylic acid, 97%
AC-19422
AS-15059
SY050143
5-Methoxy-1H-indole-2-carboxylic acid #
5-(methyloxy)-1H-indole-2-carboxylic acid
DB-012189
DB-350025
M1271
NS00031367
EN300-96643
Z1096153758
VEO