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O-Desmethyltramadol hydrochloride

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Identification
Molecular formula
C19H25ClN2O
CAS number
53747-18-5
IUPAC name
[5-methoxy-2-methyl-1-(o-tolyl)indol-3-yl]methyl-dimethyl-ammonium;chloride
State
State

At room temperature, it is in a solid state, typically in crystalline form.

Melting point (Celsius)
186.00
Melting point (Kelvin)
459.15
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.15
General information
Molecular weight
326.87g/mol
Molar mass
326.8600g/mol
Density
1.1500g/cm3
Appearence

The compound typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of [5-methoxy-2-methyl-1-(o-tolyl)indol-3-yl]methyl-dimethyl-ammonium;chloride

The solubility of the compound [5-methoxy-2-methyl-1-(o-tolyl)indol-3-yl]methyl-dimethyl-ammonium;chloride is influenced by several factors:

  • Polarity: The presence of the quaternary ammonium group suggests a degree of polarity, which typically enhances solubility in polar solvents such as water.
  • Hydrogen Bonding: The methoxy group may participate in hydrogen bonding, further aiding solubility in suitable solvents.
  • Ionization: As a halide salt, the chloride part is often more soluble, especially in aqueous solutions, as it dissociates into ions.

In general, the solubility of such a compound can be classified as high in water and organic solvents due to its ionic nature and the presence of functional groups that engage in interactions with solvents. This makes it quite versatile in terms of practical applications.

However, it is crucial to note that the exact solubility can vary based on conditions such as temperature, pH, and the presence of other solutes. Therefore, when handling this compound, one should consider performing solubility tests under specific conditions to determine the precise behavior in desired solvents.

Interesting facts

Interesting Facts about [5-Methoxy-2-methyl-1-(o-tolyl)indol-3-yl]methyl-dimethyl-ammonium; Chloride

The compound known as [5-methoxy-2-methyl-1-(o-tolyl)indol-3-yl]methyl-dimethyl-ammonium; chloride belongs to a class of compounds that showcases the fascinating intersection of organic chemistry and pharmacological applications. Its complex structure, with a core that includes an indole moiety, highlights its potential significance in medicinal chemistry.

Key Features

  • Indole Framework: The indole structure is a key component in many *bioactive* molecules, making it a focus of research in both *synthetic* and *natural* products.
  • Quaternary Ammonium Salt: As a quaternary ammonium compound, it exhibits important properties such as *cationic surfactant* behavior, which can be beneficial in various applications, including antimicrobial activity.
  • Methoxy and Methyl Substituents: These functional groups can significantly influence the compound's *biological activity*, possibly enhancing its affinity for biological targets.

Potential Applications

This compound may hold promise for several applications:

  • As an *antimicrobial agent* due to its cationic properties.
  • In *drug development*, particularly for neurological conditions owing to the presence of the indole structure.
  • In *chemical biology*, to study the interactions between small molecules and biological macromolecules.

Research Insights

When studying compounds like this one, researchers often emphasize that *structure-activity relationships* (SAR) are crucial. Understanding how changes in the molecular structure can affect activity informs the design of more effective drugs. As seen with many indole derivatives, modifications can lead to profound differences in biological outcomes.

In summary, [5-methoxy-2-methyl-1-(o-tolyl)indol-3-yl]methyl-dimethyl-ammonium; chloride exemplifies the richness of organic chemistry and its continual relevance to *pharmaceutical research*. Its intriguing properties and structural complexity make it a subject worth exploring for future scientific endeavors.

Synonyms
Of-2495
Indole, 3-((dimethylamino)methyl)-5-methoxy-2-methyl-1-o-tolyl-, monohydrochloride
13708-43-5
3-((Dimethylamino)methyl)-5-methoxy-2-methyl-1-o-tolylindole monohydrochloride