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5-Methoxy-N,N-dimethyltryptamine

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Identification
Molecular formula
C13H18N2O
CAS number
61-50-7
IUPAC name
5-methoxy-3-[[1-(2-phenylethyl)-4-piperidyl]methyl]-1H-indole
State
State

5-Methoxy-N,N-dimethyltryptamine is typically in a solid state at room temperature.

Melting point (Celsius)
69.50
Melting point (Kelvin)
342.65
Boiling point (Celsius)
465.40
Boiling point (Kelvin)
738.55
General information
Molecular weight
218.31g/mol
Molar mass
218.3110g/mol
Density
1.1400g/cm3
Appearence

5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) appears as a crystalline solid. It is usually white to off-white in color but can appear yellowish if impurities are present.

Comment on solubility

Solubility of 5-Methoxy-3-[[1-(2-phenylethyl)-4-piperidyl]methyl]-1H-indole

The solubility characteristics of 5-methoxy-3-[[1-(2-phenylethyl)-4-piperidyl]methyl]-1H-indole are influenced by its organic structure, making it an interesting compound in the realm of pharmacology and organic chemistry.

General Observations:

  • Polar vs. Non-Polar: The presence of both methoxy and piperidyl functional groups suggests that this compound could exhibit amphiphilic behavior, allowing it to interact with both polar and non-polar solvents.
  • Solvent Compatibility: Common solvents such as ethanol and dimethyl sulfoxide (DMSO) may effectively dissolve this compound due to their capacity to engage with the polar aspects of the molecule.
  • Temperature Influence: Solubility can also be temperature-dependent. Increasing temperature may enhance solubility in organic solvents, allowing better interaction between the solvent molecules and the compound.

It is important to consider specific pH levels as they can significantly alter the ionic state of the molecule. Changing the pH can affect solubility in aqueous solutions, often conferring greater solubility under certain conditions. Additionally, structural factors such as stereochemistry may also play a role in the solubility profile.

As a general statement, understanding the solubility of this compound is crucial, as it not only affects its potential drug delivery but also its behavior in various chemical environments. The exploration of solubility can lead to intriguing findings and applications in both synthetic and medicinal chemistry.

Interesting facts

Interesting Facts about 5-Methoxy-3-[[1-(2-phenylethyl)-4-piperidyl]methyl]-1H-indole

5-Methoxy-3-[[1-(2-phenylethyl)-4-piperidyl]methyl]-1H-indole, often referred to in scientific contexts as a complex compound with rich pharmacological properties, has garnered attention for its potential applications in various therapeutic areas. Here are some intriguing insights:

  • Structural Versatility: This compound features an indole ring, which is a common structural motif in many biologically active molecules. Indoles are known for their role in neurotransmission and are often found in pharmaceuticals, making them a focal point in drug design.
  • Pharmacological Potential: Compounds like this one have been investigated for their potential as neuropharmacological agents. The presence of piperidine and phenethylamine moieties often correlates with significant activity in the central nervous system, raising interest for further exploration in mental health treatments.
  • Research Applications: This compound is relevant in studies focused on serotonin or dopamine receptors, providing valuable data that may lead to the development of innovative treatments for mood disorders, anxiety, and other psychological conditions.
  • Competitive Interaction: The intricate combination of methoxy and piperidyl groups gives this compound a unique position in competitive assays where it may act as an antagonist or agonist, depending on the receptor type involved.
  • Synthesis Challenges: The synthesis of such complex compounds can be quite challenging, often requiring advanced techniques in organic chemistry, including multiple reaction phases and protection/deprotection strategies to attain the desired final product.

In summary, 5-methoxy-3-[[1-(2-phenylethyl)-4-piperidyl]methyl]-1H-indole stands at the intersection of organic chemistry and pharmacology, showcasing how detailed molecular design can lead to advancements in medicinal chemistry. As research continues, compounds like this may hold the key to unlocking new therapeutic pathways.

Synonyms
BRN 0761379
3515-58-0
INDOLE, 5-METHOXY-3-(1-PHENETHYL-4-PIPERIDYL)METHYL-
5-Methoxy-3-(N-phenylethyl-4-piperidinomethyl) indole
DTXSID90188649
DTXCID00111140
5-23-12-00085 (beilstein handbook reference)
5-Methoxy-3-{[1-(2-phenylethyl)-4-piperidinyl]methyl}-1H-indole