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5-Methoxybenzofuran

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Identification
Molecular formula
C9H8O2
CAS number
50551-74-5
IUPAC name
5-methoxybenzofuran
State
State

5-Methoxybenzofuran is typically a liquid at room temperature, with properties indicative of aromatic compounds.

Melting point (Celsius)
30.00
Melting point (Kelvin)
303.15
Boiling point (Celsius)
238.00
Boiling point (Kelvin)
511.15
General information
Molecular weight
148.16g/mol
Molar mass
148.1580g/mol
Density
1.1689g/cm3
Appearence

5-Methoxybenzofuran is a chemical compound that typically appears as a colorless to light yellow liquid. It is known for its aromatic and ether-like odor.

Comment on solubility

Solubility of 5-methoxybenzofuran

5-methoxybenzofuran exhibits intriguing solubility characteristics, which are essential for its applications in various fields:

  • Solvent Dependence: The solubility of 5-methoxybenzofuran varies significantly depending on the solvent used. It is typically soluble in organic solvents, such as ethanol, dimethyl sulfoxide (DMSO), and chloroform.
  • Temperature Influence: Increasing temperature can enhance solubility in many organic solvents. As such, it’s important to conduct solubility tests at varying temperatures to optimize dissolution.
  • pH Sensitivity: The solubility may be influenced by the pH of the solution. This could impact its reactivity and potential interactions in biological systems.

Research indicates that 5-methoxybenzofuran may have limited solubility in water, which could restrict its bioavailability in aqueous environments. This characteristic is significant in the development of formulations for therapeutic or analytical applications. Thus, when working with this compound, it is crucial to carefully select the medium to ensure optimal solubility.

In summary, the understanding of solubility in 5-methoxybenzofuran can be summarized as follows:

  1. Primarily soluble in organic solvents.
  2. Solubility varies with temperature and pH.
  3. Limited water solubility, necessitating careful application choices.
Interesting facts

Interesting Facts About 5-Methoxybenzofuran

5-Methoxybenzofuran is a fascinating compound with a structure that exemplifies the rich diversity of organic chemistry. This compound is part of the benzofuran family, which is significant in various chemical and biological contexts. Here are some intriguing aspects of 5-methoxybenzofuran:

  • Natural Occurrence: Certain benzofuran derivatives, including 5-methoxybenzofuran, can be isolated from natural sources such as plants. This raises interesting questions about the ecological roles these compounds play.
  • Pharmacological Potential: Compounds related to 5-methoxybenzofuran have been studied for their medicinal properties. Research indicates that they may exhibit anti-inflammatory and analgesic effects, making them a topic of interest in the field of drug discovery.
  • Chemical Reactivity: The methoxy group on the benzofuran moiety influences its reactivity and can provide a path for further derivatization. This feature is helpful for chemists aiming to modify the compound for specific applications.
  • Research Applications: 5-Methoxybenzofuran and its derivatives are often used in studies exploring the mechanisms of various biological pathways, particularly those related to signaling and metabolism.
  • Structural Insights: The unique bicyclic structure of benzofuran lends itself to various interactions within chemical synthesis, making it a compelling subject for researchers interested in molecular design and materials science.

In summary, 5-methoxybenzofuran is not just a simple chemical compound; it acts as a gateway to exploring broader themes in chemistry, including natural products, pharmacology, and synthetic methods. This compound underscores the idea that even the most minute substances can have significant implications across multiple scientific disciplines.

Synonyms
5-Methoxybenzofuran
13391-28-1
5-methoxy-1-benzofuran
BENZOFURAN, 5-METHOXY-
NSC 149953
BRN 0116721
VSU72383LP
NSC-149953
DTXSID40158418
5-17-04-00203 (Beilstein Handbook Reference)
DTXCID0080909
JJXPTUWJVQUHKN-UHFFFAOYSA-N
5-methoxy-benzofuran
MFCD00079770
R 7236
5-Methoxybenzo[b]furan
UNII-VSU72383LP
SCHEMBL533282
SCHEMBL826624
SCHEMBL3810173
SCHEMBL4116888
SCHEMBL15201351
SCHEMBL16295095
SCHEMBL27616644
1-Benzofuran-5-yl methyl ether #
NSC149953
AKOS006342986
SB18213
SY032575
TS-01940
DB-049841
CS-0056827