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5-Methoxybenzofuran-2-carboxaldehyde

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Identification
Molecular formula
C10H8O3
CAS number
20416-74-4
IUPAC name
5-methoxybenzofuran-2-carbaldehyde
State
State

At room temperature, 5-Methoxybenzofuran-2-carboxaldehyde exists as a solid, typically in crystalline form.

Melting point (Celsius)
73.00
Melting point (Kelvin)
346.15
Boiling point (Celsius)
386.00
Boiling point (Kelvin)
659.15
General information
Molecular weight
176.17g/mol
Molar mass
176.1730g/mol
Density
1.2370g/cm3
Appearence

5-Methoxybenzofuran-2-carboxaldehyde appears as a pale yellow solid crystalline powder. It is notable for its characteristic aldehyde odor, often distinct in compounds containing the -CHO group.

Comment on solubility

Solubility of 5-methoxybenzofuran-2-carbaldehyde

5-methoxybenzofuran-2-carbaldehyde is a compound that exhibits specific solubility properties, influenced by its molecular structure and functional groups. Understanding its solubility can be crucial for various applications, particularly in organic synthesis and pharmaceutical formulations.

Solubility Characteristics:

  • Solvent Compatibility: This compound is generally soluble in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO), due to its non-polar aromatic structure combined with polar aldehyde and ether groups.
  • Water Solubility: 5-methoxybenzofuran-2-carbaldehyde shows limited solubility in water. The hydrophobic nature of the benzofuran moiety contributes to this, making it more favorable in organic solvents.
  • Temperature Influence: Solubility can increase with temperature, which is a common behavior observed in many organic compounds. Care must be taken, however, as excess heat can lead to decomposition.

In summary, the solubility of 5-methoxybenzofuran-2-carbaldehyde is predominantly defined by its ability to dissolve in organic solvents while exhibiting restricted water solubility. This characteristic is essential for its utilization in various chemical processes, making solvent choice a critical factor in its practical applications.

Interesting facts

Interesting Facts about 5-Methoxybenzofuran-2-carbaldehyde

5-Methoxybenzofuran-2-carbaldehyde is a fascinating compound that belongs to the class of benzofuran derivatives. This compound is notable for its unique structural features and potential applications in various fields, including medicinal chemistry and organic synthesis.

Key Features

  • Functional Versatility: The presence of both a methoxy group and an aldehyde functional group makes this compound an intriguing candidate for various chemical reactions, such as nucleophilic additions and cross-coupling reactions.
  • Pharmacological Potential: Compounds derived from benzofuran structures are often investigated for their biological activities, including anti-inflammatory, anticancer, and antidiabetic properties.
  • Mix of Aromatic Characteristics: The fusion of benzene and furan rings in this compound contributes to its electronic properties, which may enhance its reactivity and stability in certain conditions.

Furthermore, the synthesis of 5-methoxybenzofuran-2-carbaldehyde can involve diverse methods, typically utilizing reactions such as Friedel-Crafts acylation or electrophilic substitutions. Its versatility opens doors for tailored synthesis to produce related compounds.

As researchers delve deeper into the properties and applications of this compound, it holds promise for advancing chemistry research and possibly leading to the development of new therapeutic agents. It serves as a fantastic example of how small structural modifications can lead to innovative functional compounds.

Synonyms
23145-19-9
5-methoxy-1-benzofuran-2-carbaldehyde
2-BENZOFURANCARBOXALDEHYDE, 5-METHOXY-
5-Methoxy-2-benzofurancarboxaldehyde
BRN 1241509
DTXSID60177722
5-18-01-00417 (Beilstein Handbook Reference)
RefChem:465544
DTXCID20100213
894-226-4
5-Methoxybenzofuran-2-carbaldehyde
5-Methoxy-benzofuran-2-carbaldehyde
MFCD01413839
5-methoxybenzo[b]furan-2-carbaldehyde
2-formyl-5-methoxybenzofuran
SCHEMBL120294
SCHEMBL6207419
5-methoxybenzofurancarboxaldehyde
SCHEMBL29985195
OPAYERWEZXLSFC-UHFFFAOYSA-N
YAA14519
STL591592
AKOS000533110
FS-6401
SY045642
DB-086523
CS-0062602
ST50570631
EN300-77404
AG-205/07906031
F061010
Z1197664683