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Methadone

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Identification
Molecular formula
C21H28ClNO
CAS number
76-99-3
IUPAC name
5-methyl-1-(1-methylpiperidin-1-ium-1-yl)-4-phenyl-hexan-3-ol
State
State

At room temperature, methadone is typically found in its hydrochloride salt form, which is a solid. It can also be dissolved into a liquid for easier administration.

Melting point (Celsius)
234.00
Melting point (Kelvin)
507.15
Boiling point (Celsius)
215.00
Boiling point (Kelvin)
488.15
General information
Molecular weight
309.45g/mol
Molar mass
309.4510g/mol
Density
1.0140g/cm3
Appearence

Methadone typically appears as a white, crystalline powder in its pure form. It is also available in liquid and tablet forms for medical use. The powder is odorless and has a bitter taste.

Comment on solubility

Solubility Characteristics of 5-methyl-1-(1-methylpiperidin-1-ium-1-yl)-4-phenyl-hexan-3-ol

The solubility of 5-methyl-1-(1-methylpiperidin-1-ium-1-yl)-4-phenyl-hexan-3-ol is influenced by various factors due to its complex molecular structure. Here are some key points to consider:

  • Polarity: The presence of an ionic group in the piperidinium moiety indicates enhanced polarity, which may increase solubility in polar solvents.
  • Hydrogen Bonding: With hydroxyl (–OH) functional groups within its structure, this compound can engage in hydrogen bonding. This might facilitate better solubility in polar solvents, such as water.
  • Hydrophobic Chains: The hexane chain and phenyl groups contribute to a hydrophobic character, suggesting that the solubility may be lower in aqueous environments but could be improved in organic solvents.
  • Solvent Compatibility: This compound is likely soluble in a range of organic solvents. Examples include:
    • Alcohols
    • Aromatics
    • Chloroform
  • Influence of Temperature: The solubility might increase with temperature, highlighting the importance of thermal dynamics in dissolution behavior.

In conclusion, while this compound may show varied solubility profiles depending on the solvent and environmental conditions, its unique structure suggests a fascinating interplay of hydrophilic and hydrophobic interactions that defines its solubility behavior. As stated, "Understanding the solubility characteristics not only aids in predicting behavior in biological systems but also guides the formulation in chemical applications." Thus, careful consideration and experimentation are essential in determining precise solubility parameters.

Interesting facts

Interesting Facts about 5-methyl-1-(1-methylpiperidin-1-ium-1-yl)-4-phenyl-hexan-3-ol

This compound, known for its complex structure, contains both aromatic and aliphatic components, making it a fascinating subject for study in both organic synthesis and medicinal chemistry.

Structural Features

The unique combination of functional groups in this compound provides it with interesting chemical properties:

  • Methylpiperidinium: The presence of a methylpiperidinium cation contributes to its stability and solubility, allowing it to interact effectively with biological systems.
  • Phenyl Group: The phenyl group aids in enhancing the compound's interactions with proteins and enzymes, potentially affecting its biological activity.
  • Stereochemistry: The various stereocenters in the structure lead to the possibility of different enantiomers, each possibly exhibiting distinct pharmacological effects.

Biological Relevance

Understanding the biological significance of 5-methyl-1-(1-methylpiperidin-1-ium-1-yl)-4-phenyl-hexan-3-ol could be critical for drug development:

  • Pharmacological Potential: Compounds of similar structures have been explored for their roles in treating neurological conditions due to their ability to cross the blood-brain barrier.
  • Future Research: Ongoing research into the function of this compound may reveal new therapeutic avenues in fields like neuropharmacology and medicinal chemistry.

Practical Applications

This compound's properties may offer exciting possibilities:

  • Drug Formulation: Due to its structural profile, 5-methyl-1-(1-methylpiperidin-1-ium-1-yl)-4-phenyl-hexan-3-ol could be explored for use in drug delivery systems.
  • Organic Synthesis: It may serve as a key intermediate in the synthesis of more complex molecules.

In conclusion, the study of 5-methyl-1-(1-methylpiperidin-1-ium-1-yl)-4-phenyl-hexan-3-ol not only highlights the intricate nature of chemical compounds but also emphasizes the importance of investigating their potential applications in various scientific fields. As emphasized by many chemists, "The beauty of chemistry lies in its complexity and the endless possibilities it presents."

Synonyms
MEPIPERPHENIDOL
Mepiperphenidol ion
Mepiperphenidol cation
13004-75-6
UNII-8I07J24F45
8I07J24F45
Piperidinium, 1-(3-hydroxy-5-methyl-4-phenylhexyl)-1-methyl-
1-methyl-1-(3-hydroxy-5-methyl-4-phenylhexyl)piperidinium
5-methyl-1-(1-methylpiperidin-1-ium-1-yl)-4-phenylhexan-3-ol
1-(3-hydroxy-5-methyl-4-phenylhexyl)-1-methylpiperidin-1-ium
CHEMBL2078910
CHEBI:135211
DTXSID601043665
BDBM50420216
Q27270560