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Nitrofurantoin

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Identification
Molecular formula
C8H6N4O5
CAS number
67-20-9
IUPAC name
5-methyl-1-[(5-nitro-2-furyl)methyleneamino]imidazolidin-2-one
State
State

At room temperature, Nitrofurantoin is typically a solid substance, appearing as crystalline powder.

Melting point (Celsius)
254.00
Melting point (Kelvin)
527.15
Boiling point (Celsius)
359.00
Boiling point (Kelvin)
632.15
General information
Molecular weight
238.16g/mol
Molar mass
238.1610g/mol
Density
1.6801g/cm3
Appearence

Nitrofurantoin is a yellow to amber crystalline compound.

Comment on solubility

Solubility of 5-methyl-1-[(5-nitro-2-furyl)methyleneamino]imidazolidin-2-one

The solubility of 5-methyl-1-[(5-nitro-2-furyl)methyleneamino]imidazolidin-2-one can vary significantly based on conditions such as temperature and the solvent used. Generally, the factors influencing solubility include:

  • Polarity of the Solvent: Compounds with significant polar functional groups tend to dissolve better in polar solvents like water.
  • Hydrogen Bonding: The presence of amino groups can lead to enhanced solubility through hydrogen bonding with water molecules.
  • Temperature: Increased temperature often boosts solubility for many organic compounds.

However, one must also consider that the extensive conjugation and the presence of the nitro group (−NO₂) in 5-methyl-1-[(5-nitro-2-furyl)methyleneamino]imidazolidin-2-one may also introduce some complexities in its solubility characteristics. As a rule of thumb, compounds like this that feature both furan and imidazolidinone structures may exhibit moderate to low solubility in common organic solvents. Therefore, it is essential to conduct empirical tests in various conditions to ascertain its solubility profile accurately.

In conclusion, understanding the solubility of such compounds is crucial for their applications in pharmaceuticals and materials science. As always, "the solvent is as important as the solute," and further studies on this compound could reveal more interesting solubility behavior.

Interesting facts

5-methyl-1-[(5-nitro-2-furyl)methyleneamino]imidazolidin-2-one

This intriguing compound, often studied in the realm of medicinal chemistry, stands out due to its unique structure and potential applications. Here are some captivating facts about this compound:

  • Therapeutic Potential: Compounds like this one, which feature a nitro group and an imidazolidinone ring, are of great interest for their potential pharmacological activities, including anti-cancer and anti-inflammatory properties.
  • Heterocyclic Chemistry: The imidazolidinone core is a member of a class of compounds known as heterocycles, which contain atoms of at least two different elements as members of their rings. This feature often imparts unique chemical reactivity and biological activity.
  • Reaction Mechanisms: The presence of the furyl moiety can enhance the compound's reactivity, making it a useful intermediate in organic synthesis or potential drug development pathways.
  • Bioisosterism: The design of such compounds often employs the concept of bioisosterism, wherein substituents are modified to improve drug-like properties while maintaining biological activity. The nitrofuran motif, specifically, is known to be a bioisostere of other pharmacologically active groups.
  • Research Applications: Studying this compound can lead to insights into developing novel therapeutic agents, especially in combating resistant strains of bacteria or cancer cells.

As researchers delve deeper into the properties and mechanisms of this compound, its versatile nature and the potential for biomedical applications continue to ignite curiosity and exploration in the scientific community. A quote from a renowned chemist captures this sentiment aptly: "Chemistry knows no boundaries; it is the bridge between the known and the unknown."