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Loxapine

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Identification
Molecular formula
C18H18ClN3O
CAS number
1977-10-2
IUPAC name
5-methyl-11-[3-(1-piperidyl)propyl]-6,11-dihydrobenzo[c][1]benzazepine
State
State

Loxapine is typically encountered as a solid at room temperature.

Melting point (Celsius)
102.00
Melting point (Kelvin)
375.15
Boiling point (Celsius)
520.00
Boiling point (Kelvin)
793.15
General information
Molecular weight
327.44g/mol
Molar mass
327.4400g/mol
Density
1.2100g/cm3
Appearence

Loxapine appears as a yellowish, crystalline powder. It is generally stable under normal conditions and should be handled in a manner consistent with pharmaceutical-grade substances.

Comment on solubility

Solubility of 5-methyl-11-[3-(1-piperidyl)propyl]-6,11-dihydrobenzo[c][1]benzazepine

The solubility of 5-methyl-11-[3-(1-piperidyl)propyl]-6,11-dihydrobenzo[c][1]benzazepine can be influenced by various factors, primarily due to its complex chemical structure.

Key Factors Affecting Solubility:

  • Polarity: The presence of both hydrophobic and hydrophilic regions in the molecule can create a challenge for solubility in water.
  • Temperature: Increasing the temperature often enhances solubility for many compounds, including those with similar structures.
  • pH Levels: The ionization state of specific functional groups may vary with pH, potentially influencing solubility.
  • Solvent Used: This compound might dissolve better in organic solvents compared to aqueous solutions due to its hydrophobic characteristics.

While specific solubility values may not be readily available, understanding these influencing factors is crucial. It can be noted that:

  1. The solubility of such compounds is typically low in water.
  2. Testing in various organic solvents is often recommended to determine practical solubility.

In conclusion, the solubility of 5-methyl-11-[3-(1-piperidyl)propyl]-6,11-dihydrobenzo[c][1]benzazepine is complex and multifaceted, necessitating careful consideration of the interactions between the compound and the solvent used. Always bear in mind that “solubility is not merely a characteristic; it is an unfolding narrative of interactions.”

Interesting facts

Interesting Facts about 5-methyl-11-[3-(1-piperidyl)propyl]-6,11-dihydrobenzo[c][1]benzazepine

This compound, known for its complex structure, belongs to a class of chemicals that has garnered significant interest in pharmacological research. Here are some intriguing aspects:

  • Structural Complexity: The presence of multiple rings and functional groups in 5-methyl-11-[3-(1-piperidyl)propyl]-6,11-dihydrobenzo[c][1]benzazepine contributes to its unique properties. This complexity allows the compound to interact with various biological targets.
  • Potential Pharmacological Applications: Compounds in this category could exhibit properties such as antidepressant and antipsychotic effects, making them valuable in mental health research. The piperidyl group suggests potential involvement in neuronal pathways, enhancing its appeal in pharmacology.
  • Challenges in Synthesis: The synthesis of such intricate compounds often poses challenges, including the need for precise control over reaction conditions to obtain the desired product. Chemists must explore various methodologies to optimize yields and purity.
  • Research Potential: Ongoing studies focus on understanding how structural variations influence the bioactivity of these molecules. Such research could lead to the development of novel therapeutic agents with enhanced efficacy and reduced side effects.

Overall, the study of 5-methyl-11-[3-(1-piperidyl)propyl]-6,11-dihydrobenzo[c][1]benzazepine not only broadens our understanding of chemical compounds but also opens doors to advancements in medicinal chemistry. As noted by researchers, "Understanding the interaction of these compounds with biological systems is key to the development of future drugs."